Serotonin receptors in platelets of bipolar and schizoaffective patients: effect of lithium treatment

Pandey, Ghanshyam N.; Pandey, Subhash C.; Ren, Xinguo; Dwivedi, Yogesh K.; Janicak, Philip G.

doi:10.1007/s00213-003-1530-y

Cited by 26 publications

(14 citation statements)

References 50 publications

(59 reference statements)

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“…The present findings contrast the results from a study on platelet binding in adults with eating disorders [12]. Moreover, increased densities have been found in depression (particularly related to suicidality) [27], bipolar disorder [28] and schizoaffective disorder [28]. Thus, our finding seems to be relatively unique among psychiatric disorders, although the 5-HT 2A receptor is not as thoroughly investigated as the serotonin transporter.…”

Section: Discussioncontrasting

confidence: 84%

Platelet serotonin transporter and 5-HT_2Areceptor binding in adolescents with eating disorders

Sigurdh¹,

Allard²,

Spigset³

et al. 2013

International Journal of Neuroscience

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The pathogenetic involvement of the serotonergic system in eating disorders is an established finding. Conclusions from platelet studies are based on results from investigations of subjects with a mean age of 20 years or more. The aim was to investigate whether previous findings in adults are valid also for adolescents who are examined within a relatively short interval after the onset of the eating disorder. [(3)H]paroxetine binding to the platelet serotonin transporter and [(3)H]lysergic acid diethylamide ([(3)H]LSD) binding to the 5-HT2A receptor was studied in 15 female adolescents with eating disorders (11 with anorexia nervosa and 4 with clearly anorectic eating behaviour not fulfilling the criteria for anorexia nervosa) and 32 controls. The patients revealed a higher density of serotonin transporters and a lower density of 5-HT2A receptors compared with healthy controls of the same age (775 ± 165 vs. 614 ± 111 fmol/mg protein (p = 0.003) for [(3)H]paroxetine binding and 215 ± 59 vs. 314 ± 151 fmol/mg protein (p = 0.005) for [(3)H]LSD binding). The findings of increased density of platelet serotonin transporters and reduced density of 5-HT2A receptors differ from previous results in older patients. The lower patient age and the short duration of disease in the present study, possibly in conjunction with variations in stress-related psychological and biological factors, may have caused these differences. Although the present findings contradict prevailing evidence, they add further information concerning the nature of serotonergic involvement in eating disorders and indicate that demographic and course-related factors might influence the regulation of the serotonin system in these disorders.

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Section: Discussioncontrasting

confidence: 84%

Platelet serotonin transporter and 5-HT_2Areceptor binding in adolescents with eating disorders

Sigurdh¹,

Allard²,

Spigset³

et al. 2013

International Journal of Neuroscience

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“…These processes are suggested to be potential therapeutic targets for lithium. 54, 55, 56 However, validation attempts failed, and no reasonable proxy marker exists.…”

Section: Discussionmentioning

confidence: 99%

Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder

et al. 2015

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Lithium is the mainstay prophylactic treatment for bipolar disorder (BD), but treatment response varies considerably across individuals. Patients who respond well to lithium treatment might represent a relatively homogeneous subtype of this genetically and phenotypically diverse disorder. Here, we performed genome-wide association studies (GWAS) to identify (i) specific genetic variations influencing lithium response and (ii) genetic variants associated with risk for lithium-responsive BD. Patients with BD and controls were recruited from Sweden and the United Kingdom. GWAS were performed on 2698 patients with subjectively defined (self-reported) lithium response and 1176 patients with objectively defined (clinically documented) lithium response. We next conducted GWAS comparing lithium responders with healthy controls (1639 subjective responders and 8899 controls; 323 objective responders and 6684 controls). Meta-analyses of Swedish and UK results revealed no significant associations with lithium response within the bipolar subjects. However, when comparing lithium-responsive patients with controls, two imputed markers attained genome-wide significant associations, among which one was validated in confirmatory genotyping (rs116323614, P=2.74 × 10−8). It is an intronic single-nucleotide polymorphism (SNP) on chromosome 2q31.2 in the gene SEC14 and spectrin domains 1 (SESTD1), which encodes a protein involved in regulation of phospholipids. Phospholipids have been strongly implicated as lithium treatment targets. Furthermore, we estimated the proportion of variance for lithium-responsive BD explained by common variants (‘SNP heritability') as 0.25 and 0.29 using two definitions of lithium response. Our results revealed a genetic variant in SESTD1 associated with risk for lithium-responsive BD, suggesting that the understanding of BD etiology could be furthered by focusing on this subtype of BD.

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“…A few studies investigated serotonin (5-hydroxytryptamine, 5-HT) levels (Takahashi, 1976;Saxena et al, 1999), monoamine oxidase (MAO) activity (Takahashi, 1977) and 5-HT2A receptors (Pandey et al, 2003) in manic patients using blood platelets as a peripheral model for the central serotonergic neurons (Plain and Berk, 2001). Manic patients had lower cholesterol levels than healthy controls (Ghaemi et al, 2000;Cassidy and Carroll, 2002;Atmaca et al, 2002), but no data are available either regarding the low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL) and triglycerides (TG) levels in mania, or platelet 5-HT, platelet MAO activity and lipid levels, especially in psychotic subtype of mania.…”

Section: Introductionmentioning

confidence: 99%

Platelet serotonin and serum lipids in psychotic mania

Šagud¹,

Mihaljević-Peleš²,

Pivac³

et al. 2007

Journal of Affective Disorders

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Serotonin receptors in platelets of bipolar and schizoaffective patients: effect of lithium treatment

Cited by 26 publications

References 50 publications

Platelet serotonin transporter and 5-HT_2Areceptor binding in adolescents with eating disorders

Platelet serotonin transporter and 5-HT_2Areceptor binding in adolescents with eating disorders

Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder

Platelet serotonin and serum lipids in psychotic mania

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Serotonin receptors in platelets of bipolar and schizoaffective patients: effect of lithium treatment

Cited by 26 publications

References 50 publications

Platelet serotonin transporter and 5-HT2Areceptor binding in adolescents with eating disorders

Platelet serotonin transporter and 5-HT2Areceptor binding in adolescents with eating disorders

Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder

Platelet serotonin and serum lipids in psychotic mania

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Product

Resources

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Platelet serotonin transporter and 5-HT_2Areceptor binding in adolescents with eating disorders

Platelet serotonin transporter and 5-HT_2Areceptor binding in adolescents with eating disorders