Serotonin receptor 1B (HTR1B) genotype associated with milk production traits in cattle

Zhang, C.L.; Chen, H.; Wang, Y.H.; Zhang, R.F.; Lan, Xianyong; Lei, Chuzhao; Zhang, Long; Zhang, A.L.; Hu, Shen

doi:10.1016/j.rvsc.2007.10.014

Cited by 14 publications

(17 citation statements)

References 15 publications

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“…Fatty acids, as energy signal, affect the activity of hypothalamic fat-sensitive neurons and impair nervous control of energy homeostasis [48]. HTR1B was also shown to affect milk production performance in Chinese Holstein [49].…”

Section: Discussionmentioning

confidence: 99%

Genome Wide Association Study Identifies 20 Novel Promising Genes Associated with Milk Fatty Acid Traits in Chinese Holstein

et al. 2014

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Detecting genes associated with milk fat composition could provide valuable insights into the complex genetic networks of genes underling variation in fatty acids synthesis and point towards opportunities for changing milk fat composition via selective breeding. In this study, we conducted a genome-wide association study (GWAS) for 22 milk fatty acids in 784 Chinese Holstein cows with the PLINK software. Genotypes were obtained with the Illumina BovineSNP50 Bead chip and a total of 40,604 informative, high-quality single nucleotide polymorphisms (SNPs) were used. Totally, 83 genome-wide significant SNPs and 314 suggestive significant SNPs associated with 18 milk fatty acid traits were detected. Chromosome regions that affect milk fatty acid traits were mainly observed on BTA1, 2, 5, 6, 7, 9, 13, 14, 18, 19, 20, 21, 23, 26 and 27. Of these, 146 SNPs were associated with more than one milk fatty acid trait; most of studied fatty acid traits were significant associated with multiple SNPs, especially C18:0 (105 SNPs), C18 index (93 SNPs), and C14 index (84 SNPs); Several SNPs are close to or within the DGAT1, SCD1 and FASN genes which are well-known to affect milk composition traits of dairy cattle. Combined with the previously reported QTL regions and the biological functions of the genes, 20 novel promising candidates for C10:0, C12:0, C14:0, C14:1, C14 index, C18:0, C18:1n9c, C18 index, SFA, UFA and SFA/UFA were found, which composed of HTR1B, CPM, PRKG1, MINPP1, LIPJ, LIPK, EHHADH, MOGAT1, ECHS1, STAT1, SORBS1, NFKB2, AGPAT3, CHUK, OSBPL8, PRLR, IGF1R, ACSL3, GHR and OXCT1. Our findings provide a groundwork for unraveling the key genes and causal mutations affecting milk fatty acid traits in dairy cattle.

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Section: Discussionmentioning

confidence: 99%

Genome Wide Association Study Identifies 20 Novel Promising Genes Associated with Milk Fatty Acid Traits in Chinese Holstein

et al. 2014

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“…We have not yet done studies to ascribe particular functions to 5-HT2A in the mammary gland, but this is obviously a fertile research area. Additionally, polymorphisms in the 5-HT1B receptor, which has been localized to the endothelium in the bovine mammary gland (78), have been associated with differences in milk yield (81).…”

Section: Receptorsmentioning

confidence: 99%

Serotonin: A Local Regulator in the Mammary Gland Epithelium

Horseman

Collier

2014

Annu. Rev. Anim. Biosci.

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Serotonin (5-hydroxytryptamine, 5-HT) is a very simple molecule that plays key roles in complex communication mechanisms within the animal body. In the mammary glands, serotonin biosynthesis and secretion are induced in response to dilation of the alveolar spaces. Since its discovery several years ago, mammary 5-HT has been demonstrated to perform two homeostatic functions. First, serotonin regulates lactation and initiates the transition into the earliest phases of involution. Second, serotonin is a local signal that induces parathyroid hormone-related peptide (PTHrP), which allows the mammary gland to drive the mobilization of calcium from the skeleton. These processes use different receptor types, 5-HT7 and 5-HT2, respectively. In this review, we provide synthetic perspectives on the fundamental processes of lactation homeostasis and the adaptation of calcium homeostasis for lactation. We analyze the role of the intrinsic serotonin system in the physiological regulation of the mammary glands. We also consider the importance of the mammary serotonin system in pathologies and therapies associated with lactation and breast cancer.

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“…In 2008, two papers suggested that the mammary gland 5-HT system might be functional in dairy cows; Hernandez et al (2008), provided evidence of serotonin biosynthesis in cow mammary gland cells and demonstrated effects on milk variables when either 5-HT or a 5-HT receptor blocker was infused into the gland. Zhang et al (2008) showed that genetic mutations of one of the 5-HT receptors (5-HT1B) corresponded to increased milk yield. Major components of the 5-HT biochemical signal transduction pathways in MECs were reported by Pai and Horseman, 2008.…”

Section: Altered Dry Periodsmentioning

confidence: 99%

Effects of continuous lactation and short dry periods on mammary function and animal health

Collier

Annen-Dawson

Pezeshki

2012

Animal

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The dry period is required to facilitate cell turnover in the bovine mammary gland in order to optimize milk yield in the next lactation. Traditionally, an 8-week dry period has been a standard management practice for dairy cows based on retrospective analyses of milk yields following various dry period lengths. However, as milk production per cow has increased, transitioning cows from the nonlactating state to peak milk yield has grown more problematic. This has prompted new studies on dry period requirements for dairy cows. These studies indicate a clear parity effect on dry period requirement. First parity animals require a 60-day dry period, whereas lactations following later parities demonstrate no negative impact with 30-day dry period or even eliminating the dry period when somatotropin (ST) is also used to maintain milk yields. Shortened dry periods in first parity animals were associated with reduced mammary cell turnover during the dry period and early lactation and increased numbers of senescent cells and reduced functionality of lactating alveolar mammary cells postpartum. Use of ST and increased milking frequency postpartum reduced the impact of shortened dry periods. The majority of new intramammary infections occur during the dry period and persist into the following lactation. There is therefore the possibility of altering mastitis incidence by modifying or eliminating the dry period in older parity animals. As the composition of mammary secretions including immunoglobulins may be reduced when the dry period is reduced or eliminated, there is the possibility that the immune status of cows during the peripartum period is influenced by the length of the dry period.

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Serotonin receptor 1B (HTR1B) genotype associated with milk production traits in cattle

Cited by 14 publications

References 15 publications

Genome Wide Association Study Identifies 20 Novel Promising Genes Associated with Milk Fatty Acid Traits in Chinese Holstein

Genome Wide Association Study Identifies 20 Novel Promising Genes Associated with Milk Fatty Acid Traits in Chinese Holstein

Serotonin: A Local Regulator in the Mammary Gland Epithelium

Effects of continuous lactation and short dry periods on mammary function and animal health

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