Serotonin Promotes Vesicular Association and Fusion by Modifying Lipid Bilayers
Debsankar Saha Roy,
Ankur Gupta,
Vicky Vishvakarma
et al.
Abstract:The primary event in chemical neurotransmission involves
the fusion
of a membrane-limited vesicle at the plasma membrane and the subsequent
release of its chemical neurotransmitter cargo. The cargo itself is
not known to have any effect on the fusion event. However, amphiphilic
monoamine neurotransmitters (e.g., serotonin and dopamine) are known
to strongly interact with lipid bilayers and to affect their mechanical
properties, which can in principle impact membrane-mediated processes.
Here, we probe whether s… Show more
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