Chronic infection with the hepatitis C virus (HCV) is a worldwide health problem. 1 The mainstay of treatment includes the use of pegylated interferon-a (peginterferon alfa). Interferon (IFN) therapy is frequently associated with psychiatric adverse events, such as depressive disorders, which occur in approximately 30% of patients. 2 Selective serotonin reuptake inhibitors (SSRI) are the first-line treatment of choice for IFN-associated depression. 3 However, nonresponse or poor response is common. 4 Antidepr… Show more
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