Serotonin

Clendenning, William E.

doi:10.1001/archderm.1959.01560170001001

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Action On Capillary Permeability1

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1960

1989

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Cited by 19 publications

(1 citation statement)

References 25 publications

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“…In man, for example, intradermal 5-HT is actually capable of producing changes in the calibre of capillaries (generally local erythema) but does not cause any whealing [571,261]. On the contrary, rather a thickening effect of 5-HT on capillaries could be demonstrated in some cases, e.g.…”

Section: Action On Capillary Permeabilitymentioning

confidence: 99%

Recent Research in the Field of 5-Hydroxytryptamine and Related Indolealkylamines

Erspamer

1961

Fortschritte Der Arzneimittelforschung / Progress in Drug Research / Progrès Des Recherches Pharmaceutiques

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Section: Action On Capillary Permeabilitymentioning

confidence: 99%

Recent Research in the Field of 5-Hydroxytryptamine and Related Indolealkylamines

Erspamer

1961

Fortschritte Der Arzneimittelforschung / Progress in Drug Research / Progrès Des Recherches Pharmaceutiques

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Methacholine Chloride

Clark¹

1960

Arch Dermatol

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Mediators of Inflammation

Stoughton¹

1966

Arch Dermatol

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MAST cell amines, platelet-activating factor (PAF), Inhibition of NO-synthase and thromboxanes and leukotrienes have been shown to be released during nitric oxide-synthase degranulation of rat omentai mast inhibition in the rat intestine. Mast cells in rat ce[ls in vitro isolated omentum (OMCs) or isolated from the rat peritoneal cavity (PMCs) have been used here to investigate the relationship(s) between these agents. N-nitro-L-arginine methyl ester (L-NAME, A.M. Northover cA and B. J. Northover 100 IM) caused some degranulation of OMCs, but no enhancement of histamine release from PMCs. PAF (5 IM) and U46619 (1 IM) degranulated Department of Pharmaceutical Sciences, School of OMCs and enhanced histamine release from PMCs. Pre-treatment of the omentum with Applied Sciences, De Montfort University, Leicester BN52021 (10 IM) inhibited degranulation of LE1 9BH, UK OMCs in response to L-NAME, PAF or U46619. Pretreatment with 1-benzylimidazole (5 or 50 IM) inhibited the effect of L-NAME but not that of CACorresponding AuthorPAF. Indomethacin (1 IM) or sodium nitroprusside (10 IM) also inhibited the effects of L-NAME, but nordihydroguaiaretic acid (30 IM) did not. In PMCs BN52021 inhibited PAF-induced, but not U46619-induced, release of histamine. These results suggest that inhibition of nitric oxidesynthase in the omentum by L-NAME allows thromboxanes to release PAF, which in turn degranulates and releases histamine from OMCs.

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Serotonin

Cited by 19 publications

References 25 publications

Recent Research in the Field of 5-Hydroxytryptamine and Related Indolealkylamines

Recent Research in the Field of 5-Hydroxytryptamine and Related Indolealkylamines

Methacholine Chloride

Mediators of Inflammation

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