Serotonin Modifies the Neuronal Inhibitory Responses to γ-Aminobutyric Acid in the Red Nucleus: A Microiontophoretic Study in the Rat

Licata, F.; Volsi, Guido Li; Mauro, Michela Di; Fretto, Giovanna; Ciranna, Lucia; Santangelo, F

doi:10.1006/exnr.2001.7533

Cited by 6 publications

(4 citation statements)

References 88 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the red nucleus (RN), a work from our laboratories shows that 5-HT enhances GABA responses in neurons mostly located in the rostral part of the nucleus and this effect is mediated by activation of 5-HT 1A receptors; viceversa, activation of 5-HT 2A receptors depresses GABAmediated inhibition of rubral neurons mostly located in the caudal part of the nucleus [108]. Thus 5-HT is able to exert a dual control on GABA-ergic inhibition in the RN: in particular, inhibition is reduced by 5-HT in the RN area giving rise to rubro-spinal fibers, and is instead reinforced in RN areas involved in a neural circuit delivering information from substantia nigra to reticular substance.…”

Section: Modulation Of Gaba-mediated Transmissionmentioning

confidence: 99%

See 1 more Smart Citation

Serotonin as a Modulator of Glutamate- and GABA-Mediated Neurotransmission: Implications in Physiological Functions and in Pathology

Ciranna

2006

267

170

View full text Add to dashboard Cite

Abstract:The neurotransmitter serotonin (5-HT), widely distributed in the central nervous system (CNS), is involved in a large variety of physiological functions. In several brain regions 5-HT is diffusely released by volume transmission and behaves as a neuromodulator rather than as a "classical" neurotransmitter. In some cases 5-HT is co-localized in the same nerve terminal with other neurotransmitters and reciprocal interactions take place. This review will focus on the modulatory action of 5-HT on the effects of glutamate and -amino-butyric acid (GABA), which are the principal neurotransmitters mediating respectively excitatory and inhibitory signals in the CNS. Examples of interaction at preand/or post-synaptic levels will be illustrated, as well as the receptors involved and their mechanisms of action. Finally, the physiological meaning of neuromodulatory effects of 5-HT will be briefly discussed with respect to pathologies deriving from malfunctioning of serotonin system.

show abstract

Section: Modulation Of Gaba-mediated Transmissionmentioning

confidence: 99%

“…As already cited, in the motor system 5-HT either enhances [80,82,106,119,168,187] or depresses [61,75,102,106,107,118] glutamate-mediated transmission in distinct structures. Also for GABA-mediated transmission either enhancement [39,44,108] or decrease [36,108] by 5-HT have been observed in structures controlling movement.…”

Section: Role In Motor Controlmentioning

confidence: 99%

Serotonin as a Modulator of Glutamate- and GABA-Mediated Neurotransmission: Implications in Physiological Functions and in Pathology

Ciranna

2006

267

170

View full text Add to dashboard Cite

show abstract

“…In the NTS slice study, we reported that ketanserin potentiated the excitatory effect of noradrenaline on the spontaneous discharge of NTS neurons 24 . Recently, it was reported that ketanserin is able to block the depressive action of 5‐HT on GABA responses 25 . It is well known that GABA is an inhibitory transmitter that plays an important role in the baroreflex system.…”

Section: Discussionmentioning

confidence: 99%

“…24 Recently, it was reported that ketanserin is able to block the depressive action of 5-HT on GABA responses. 25 It is well known that GABA is an inhibitory transmitter that plays an important role in the baroreflex system. In addition, ketanserin may sensitize cardiac vagal afferent mechanisms in SHR to normalize reflex bradycardic function.…”

Section: Discussionmentioning

confidence: 99%

Ketanserin stabilizes blood pressure in conscious spontaneously hypertensive rats

Xie

Chu

et al. 2003

Clin Exp Pharma Physio

View full text Add to dashboard Cite

1. It has been demonstrated that blood pressure variability (BPV) is increased in hypertension and related to organ damage. It will be important to lower BPV in the treatment of hypertension. The present study was designed to investigate the effect of ketanserin, a 5-HT2A receptor antagonist with a weak alpha1-adrenoceptor blocking effect, on BPV in conscious spontaneously hypertensive rats (SHR). 2. It was found that ketanserin decreased blood pressure (BP) and BPV in SHR when administered intravenously (3 mg/kg, i.v.). Ketanserin decreased BPV, but not the BP level, when administered intracerebroventricularly (50 microg/rat, i.c.v.). 3. Prazosin, an alpha1-adrenoceptor antagonist, lowered BP but did not affect BPV when given either i.v. (0.5 mg/kg) or i.c.v. (30 microg/rat). Ritanserin (0.625 mg/kg, i.v.; 40 microg/rat, i.c.v.), a 5-HT2A receptor antagonist, decreased BPV only when administered i.c.v. and did not modify the BP level. 4. Ketanserin enhanced arterial baroreflex function in SHR when given either i.v. or i.c.v. 5. The stabilizing effect of ketanserin on BP was persistent when administered intragastrically. This administration route is similar to oral administration clinically. 6. It is concluded that ketanserin is an antihypertensive agent with an effect of reducing BPV. This effect is mainly mediated by central 5-HT2A receptors and is probably attributable to the restoration of arterial baroreflex function.

show abstract

Precerebellar Nuclei and Red Nucleus

Ruigrok

2004

The Rat Nervous System

110

View full text Add to dashboard Cite

Serotonin Modifies the Neuronal Inhibitory Responses to γ-Aminobutyric Acid in the Red Nucleus: A Microiontophoretic Study in the Rat

Cited by 6 publications

References 88 publications

Serotonin as a Modulator of Glutamate- and GABA-Mediated Neurotransmission: Implications in Physiological Functions and in Pathology

Serotonin as a Modulator of Glutamate- and GABA-Mediated Neurotransmission: Implications in Physiological Functions and in Pathology

Ketanserin stabilizes blood pressure in conscious spontaneously hypertensive rats

Precerebellar Nuclei and Red Nucleus

Contact Info

Product

Resources

About