Serotonin Involvement in Lisuride-induced Mounting and in Sleep

Abstract

Mounting behavior of rats induced by several drugs, such as e.g. p-CPA, 5,7-dihydroxytryptamine, L-DOPA or lisuride, appears to result from a combined decrease of 5-hydroxytryptamine (5-HT) and increase of dopamine (DA) neurotransmission. In this paper, lisuride-induced mounting is proposed as a behavioral model for detecting pharmacologically active drugs that interact with monoaminergic mechanisms, e.g. 5-HT reuptake blockers and type A monoamine oxidase inhibitors. With regard to sleep, 5-HT appears to sustain a relevant part in controlling the sleep-wakefulness cycle. However, other transmitters or neuromodulators (catecholamines, oligopeptides etc.) may also be involved in sleep mechanisms.

Treatment with a serotonin-depleting regimen of MDMA prevents conditioned place preference to sex in male rats.

“…Indeed, studies have shown that treatment of rats with drug regimens that result in increased 5-HT neurotransmission—including drugs that evoke 5-HT release, stimulate 5-HT synthesis, or inhibit 5-HT reuptake—results in a decrease in male copulatory behavior (Ahlenius & Larsson, 1991; Ahlenius, Larsson, & Svensson, 1980; Foreman, Hall, & Love, 1992). Conversely, drugs that reduce 5-HT neurotransmission by antagonizing postsynaptic 5-HT receptors or acting as agonists at 5-HT 1A autoreceptors facilitate sex behavior (Ahlenius, Larsson, & Arvidsson, 1989; Da Prada, Bonetti, Scherschlicht, & Bondiolotti, 1985; Fernandez-Guasti & Escalante, 1991). Furthermore, the administration of 5,7-dihydroxytryptamine or p-chloroamphetamine (drugs that selectively destroy 5-HT nerve terminals) also stimulates sexual behavior (Da Prada, Pieri, Keller, Pieri, & Bonetti, 1978; Fernandez-Guasti & Escalante, 1991; Sodersten, Berge, & Hole, 1978).…”

Modulatory role of serotonin in neural information processing: Implications for human psychopathology.

“…Sexual behavior is also influenced by manipulations of the 5-HT system. Decreases in 5-HT activity through neurotoxic lesioning, PCPA administration, or receptor antagonism facilitate sexual behavior in both male and female animals (Daprada, Bonetti, Scherschlicht, & Bondiolotti, 1985; Hansen & Ross, 1983; Messing, 1978; Zemlan, 1978). This facilitation is due to alterations in diencephalic 5-HT (especially the MFB and hypothalamic nuclei; Hansen & Ross, 1983) because intrathecally administered 5, 7-DHT has little effect on sexual behavior (Hansen & Ross, 1983).…”

“…This facilitation is due to alterations in diencephalic 5-HT (especially the MFB and hypothalamic nuclei; Hansen & Ross, 1983) because intrathecally administered 5, 7-DHT has little effect on sexual behavior (Hansen & Ross, 1983). The enhanced sexual behavior induced by decreased 5-HT activity can be reversed with fenfluramine, 5-HTP, 5-HT uptake inhibition, and receptor agonism (Daprada et al, 1985; Messing, 1978; Zemlan, 1978). Increased 5-HT activity alone results in a suppression of sexual behavior (Zemlan, 1978).…”

“…First, the magnitude of response in 5-HT deficient conditions would be increased. For instance, decreased 5-HT activity leads to behavioral increases such as sexual behavior (Daprada et al, 1985; Hansen & Ross, 1983; Messing, 1978; Zemlan, 1978), food intake (Blundell, 1984), aggression (Diringer et al, 1982; File et al, 1979; File et al, 1981; Kempf et al, 1984; McKenzie, 1981; Valzelli, 1981), and startle responsivity (Davis, 1984; Davis et al, 1980; Geyer et al, 1980), as well as facilitation of signals related to perceptual processes such as enhancement of aversive stimulation of the PAG (Graeff, 1984, 1987) and nociception (Auerbach et al, 1985; Ogren, 1985a). Behaviors modulated by 5-HT appear to be especially facilitated by decreased 5-HT activity when facilitatory signals of either internal or external origin drive the behavior.…”

Uptake, Release, and Subcellular Localization of l‐Methyl‐4‐Phenylpyridinium in Blood Platelets

“…In some experiments, human PRP was preincubated for 15 min at 37°C with various drugs before addition of 5 nM [3H]MPP+. The active uptake of [3H]MPP+ was calculated by subtraction of the amount of radioactivity measured in the presence of the specific 5-HT uptake blocker cianopramine at 10 pMfrom the total radioactivity taken up (Da Prada et al, 1985~) or of (-)-paroxetine (Buus-Lassen, 1978).…”