Serotonin initiates and autoamplifies its own synthesis during mouse central nervous system development.

Vitry, F. De; Hamon, Michel; Catelon, J.; Dubois, M. P.; Thibault, Jean‐François

doi:10.1073/pnas.83.22.8629

Cited by 54 publications

(18 citation statements)

References 13 publications

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“…This, together with an elevation during the same period in the ac tivity of T5-H and its substrate, suggests that the 5-HT synthesis is enhanced in the brain of nutritionally deprived fetuses, indicating a prenatal involvement of the serotonin sys tem that could influence some differentia tion processes. Lauder et al [12], Lauder [13], Whitaker-Azmitia and Azmitia [14], and De Vitry et al [42] have suggested an important role for serotonin in the prenatal period in brain differentiation of 5-HT path ways or probably acting on other cell sys tems. Haydon et al [15] showed an influence of 5-HT on growth cone development and on the establishment or synaptic communica tion in tissue culture.…”

Section: Discussionmentioning

confidence: 99%

Perinatal Brain Serotonin Metabolism in Rats Malnourished in utero

Manjarrez-Gutiérrez¹,

Chagoya²,

Hernández³

1988

Neonatology

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The fetal brain serotonin metabolism has been studied in two types of gestationally malnourished rats: protein-calorie and after ligation of one branch of the uterine artery. The results showed an elevation of L-tryptophan and serotonin content and an enhancement of tryptophan-5-hydroxylase activity in the malnourished fetal brain, continuing up to day 10 of postnatal life. The possible implications of these early changes of the serotoninergic system in brain differentiation and a lasting change in tryptophan-5-hydroxylase kinetics are proposed for further study.

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Section: Discussionmentioning

confidence: 99%

Perinatal Brain Serotonin Metabolism in Rats Malnourished in utero

Manjarrez-Gutiérrez¹,

Chagoya²,

Hernández³

1988

Neonatology

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“…Using primary cultures of hypothalamic cells from fetal mice, De Vitry and al. [33,34], induced the expression of a marker of monoaminergic neuron differentiation: the enzyme aromatic L-amino acid decarboxylase, by treatment of the cultures with the 5-HT ago-…”

Section: Neurotrophic Effects Of Neuroactive Molecules During Brain Dmentioning

confidence: 99%

Trophic Effects of Neurotransmitters during Brain Maturation

Emerit

Riad

Hamon³

1992

Neonatology

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Besides their neurotransmitter and/or neuromodulatory roles, many neuroactive substances synthesized and released during brain development can also directly influence neuronal differentiation. Transitory expression of neurotransmitters, their metabolic enzymes and their receptors is only one aspect of this trophic role. The most considerable progress in neurotrophic factor research has been made with the use of primary cultures of neuronal cells, and numerous studies have focused on the effects of neurotransmitters on the differentiation of cells at various stages of development. Thus, several neuropeptides like VIP, substance P, enkephalins, somatostatin, and monoamines, can modulate neuronal differentiation, but only during a limited period of fetal life. Among the monoamines, it was shown that, depending on the target, 5-HT stimulates the development of the neuropile, the myelinization of axons, the differentiation of the synaptic contacts, induces markers of monoaminergic neuron differentiation, inhibits the development of the growth cone, decreases the branching of neurites, and influences the survival, cell body size, and neurite outgrowth in several neuronal cultures. 5-HT can also indirectly influence the differentiation of serotonergic neurons by the intermediate of astrocytes, and it was shown in our laboratory that 5-HT_1A agonists can stimulate the cholinergic parameters of primary cultures of rat fetal septal neurons. At the molecular level, the events triggered by neurotransmitters that underlie their neurotrophic action probably involve the transmembrane influx of calcium. To date, calcium regulation of cellular processes is one of the most rapidly expanding areas of research in developmental neurobiology.

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“…In this present work, we focused on the serotonin (5-HT) system because earlier evidence indicates that 5-HT can act as a regulatory or trophic factor during neurogenesis for the development of 5-HT and other neurons [8,13,17,24,26,45]. The actions of 5-HT in neurogenesis appear to be mediated by astroglial 5-HT 1A receptors and their stimulation results in the release of a serotonergic growth factor, S100ß [1,44].…”

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confidence: 99%

Alcohol Deters the Outgrowth of Serotonergic Neurons at Midgestation

2001

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We have previously demonstrated that treatment of pregnant C57BL mice from gestation days 8 to 14 with alcohol with 20% ethanol-derived calories (EDC) reduced the number of serotonin (5-HT) neurons and retarded their migration in the fetal brains. In the present study, we obtained similar results with the use of 25% EDC and extended our previous findings by demonstrating that besides the alteration of the number of 5-HT neurons, prenatal alcohol exposure also affects their projecting fibers in their early development. Pregnant C57BL mice were divided into an alcohol-exposed (ALC) group given 25% EDC (4.49%, v/v), a pair-fed group to the ethanol-fed group (PF) and a chow-fed group (Chow). The PF and Chow groups served as controls. Our results showed that in the ALC group, when compared with the control groups, prenatal alcohol exposure with 25% EDC reduced the number of 5-HT-immunoreactive neurons in both the median and dorsal raphe, and the amount of 5-HT-immunoreactive fibers in the medial forebrain bundle (MFB). The diameter of the 5-HT-immunoreactive MFB was also reduced as a result of treatment. No significant differences of the above parameters were found between the PF and Chow groups. The previous and present work confirmed that alcohol reduces the normal formation and growth of 5-HT neurons in the midbrain. Furthermore, the projection of 5-HT fibers, in density as well as in distribution, is reduced in the major trajectory bundle. This may affect the amount of 5-HT fibers available to the forebrain. In light of the importance of the 5-HT system in brain development, alcohol may affect the growth of the forebrain through its effect on 5-HT signaling.

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Serotonin initiates and autoamplifies its own synthesis during mouse central nervous system development.

Cited by 54 publications

References 13 publications

Perinatal Brain Serotonin Metabolism in Rats Malnourished in utero

Perinatal Brain Serotonin Metabolism in Rats Malnourished in utero

Trophic Effects of Neurotransmitters during Brain Maturation

Alcohol Deters the Outgrowth of Serotonergic Neurons at Midgestation

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