Serotonin Influences Locomotion in the Nudibranch Mollusc <i>Melibe leonina</i>

Lewis, Stefanie L.; Lyons, Deborah E.; Meekins, Tiffanie L.; Newcomb, James M.

doi:10.1086/bblv220n3p155

Cited by 10 publications

(7 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar effects have also been observed in other freshwater and marine gastropod species, such as Leptoxis carinata, Stagnicola elodes, Tegula fasciatus, Urospalpinx cinerea, Nucella ostrina, and Lithopoma americanum after exposure to either venlafaxine, citalopram, or other antidepressants [31,32,93]. In gastropod species, it is well-known that locomotion and mucus secretion are strongly serotonin-dependent [94][95][96][97]. As venlafaxine acts as a serotonin re-uptake inhibitor and, thus, interferes with the serotonin metabolism, this interaction may disturb the co-ordination of mucus secretion, ciliate epithelium activity, and muscle cell functions [96].…”

Section: Discussionsupporting

confidence: 69%

Effects of the Antidepressants Citalopram and Venlafaxine on the Big Ramshorn Snail (Planorbarius corneus)

Eckstein

Köhler

Tisler

et al. 2021

Water

View full text Add to dashboard Cite

Depression is a serious health issue and, being such, treatment for it has become a topic of increasing concern. Consequently, the prescription rates of antidepressants have increased by about 50% over the past decade. Among antidepressants, citalopram and venlafaxine are the most frequently prescribed in Germany. Due to the high consumption and low elimination rates of both antidepressants during wastewater purification, they are frequently found in surface waters, where they may pose a risk to the aquatic environment. For the present study, we conducted experiments with the big ramshorn snail, which we exposed to environmentally relevant and explicitly higher concentrations (1–1000 µg/L) of the antidepressants citalopram and venlafaxine. We investigated apical endpoints, such as weight, mortality, behavioural changes, B-esterase activity, Hsp70 stress protein level and superoxide dismutase activity, as well as the tissue integrity of the hepatopancreas in the exposed snails. Citalopram and venlafaxine had no effects on the B-esterase activity, Hsp70 level and superoxide dismutase activity. Citalopram exposure resulted in weight reduction and tissue reactions in the hepatopancreas of snails exposed to 1000 µg/L. In contrast, venlafaxine did not induce comparable effects, but impacted the behaviour (sole detachment) of snails exposed to 100 µg/L and 1000 µg/L of the antidepressant. These results revealed that venlafaxine can affect snails at concentrations 10 times lower than citalopram. For this, in 2020 venlafaxine was introduced in the “Surface Water Watch List”, a list of potential pollutants that should be carefully monitored in surface water by the EU Member States.

show abstract

Section: Discussionsupporting

confidence: 69%

Effects of the Antidepressants Citalopram and Venlafaxine on the Big Ramshorn Snail (Planorbarius corneus)

Eckstein

Köhler

Tisler

et al. 2021

Water

View full text Add to dashboard Cite

show abstract

“…These observations illustrate the complexity of the serotonergic modulations of locomotor networks. It is also worth mentioning that 5-HT action may differ between closely related species as it has been described in nudibranch mollusks [67,68].…”

Section: Motor Activity and Locomotionmentioning

confidence: 98%

“…5-HT is a major neuromodulator of motor behaviors ( Figure 1A) in many species belonging to different invertebrate phyla. This includes flatworms [58], cnidarians [59], nematodes [60], annelids [61,62], arthropods (insects and crustaceans, [63][64][65]), and mollusks [66][67][68][69]. Part of our knowledge comes from studies investigating the ecological/toxicological consequences of SSRIs used as antidepressants, released in sanitary water, and finally spread in rivers [63,65,[70][71][72].…”

Section: Motor Activity and Locomotionmentioning

confidence: 99%

Serotonin in Animal Cognition and Behavior

Bacqué-Cazenave

Bharatiya

Barrière

et al. 2020

IJMS

204

111

View full text Add to dashboard Cite

Serotonin (5-hydroxytryptamine, 5-HT) is acknowledged as a major neuromodulator of nervous systems in both invertebrates and vertebrates. It has been proposed for several decades that it impacts animal cognition and behavior. In spite of a completely distinct organization of the 5-HT systems across the animal kingdom, several lines of evidence suggest that the influences of 5-HT on behavior and cognition are evolutionary conserved. In this review, we have selected some behaviors classically evoked when addressing the roles of 5-HT on nervous system functions.In particular, we focus on the motor activity, arousal, sleep and circadian rhythm, feeding, social interactions and aggressiveness, anxiety, mood, learning and memory, or impulsive/compulsive dimension and behavioral flexibility. The roles of 5-HT, illustrated in both invertebrates and vertebrates, show that it is more able to potentiate or mitigate the neuronal responses necessary for the fine-tuning of most behaviors, rather than to trigger or halt a specific behavior. 5-HT is, therefore, the prototypical neuromodulator fundamentally involved in the adaptation of all organisms across the animal kingdom.The organization of the 5-HT systems is completely different between species ranging from a limited number of cells in Aplysia or Drosophila (100 5-HT immunoreactive cells) to several thousand neurons in vertebrates. The variety and the heterogeneity of 5-HT neurons have been highlighted in vertebrates [7] as well as in invertebrates [8]. In general, the 5-HT systems in animals comprise 5-HT neurons, which share a particular shape made of thousands of varicosities, leading to the concept of volume transmission [9], and several 5-HT receptors (5-HTRs). In vertebrates, 5-HT neurons are localized in the midbrain raphe nuclei described as the B1-B9 cell groups [1,10]. The raphe pallidus, obscurus, and pontis form a caudal cluster (B1-B5), whereas the dorsal raphe and median raphe form a rostral cluster in the pons (B6-B9) [11]. The caudal raphe group projects to the spinal cord and the rostral group to the forebrain via an extensive and diffuse innervation. The dorsal raphe nucleus contains the highest number of 5-HT neurons and its anatomical sub-regions display some degrees of specific innervation of the forebrain [12][13][14]. The median and dorsal raphe nuclei receive excitatory and inhibitory inputs from most brain areas [15]. In crustaceans or insects, 5-HT neurons are widely present in each of the ventral cord ganglia, display large local ramifications that act in multiple neuropil areas, and some axonal branches form three pairs of rostrocaudal fibers [16][17][18][19]. Presumably, two of those fibers would project anteriorly and one posteriorly to the entire nervous system [20]. 5-HT neurons are often localized close to sensory integration input area in the brain of arthropods and some 5-HT cells in the abdominal ganglia of crayfish nerve cord are sensitive to the mechanical stimulation of abdominal segmental fringe hairs [21]. In cnidarians, 5-HT cells ...

show abstract

“…Serotonin controls pedal ciliary activity in marine snails, such as Tritonea diomedea (Audesirk et al, 1979) and freshwater snails, Lymnaea stagnalis (Syed and Winlow, 1989) and Planorbis corneus (Deliagina and Orlovsky, 1990). Serotonin also controls pedal muscle contractions and it has been shown to regulate swimming in the nudibranch Melibe leonine (Lewis et al 2011). In land snails, Helix lucorum, serotonin accelerates locomotion and stimulates crawling while dopamine causes muscular contractions of the foot regulating its length (Pavlova, 2001).…”

Section: Overview Of Neurohormones Impacted By Antidepressants a Molluscamentioning

confidence: 99%

The biological effects of antidepressants on the molluscs and crustaceans: A review

2014

View full text Add to dashboard Cite

Antidepressants are among the most commonly detected human pharmaceuticals in the aquatic environment. Since their mode of action is by modulating the neurotransmitters serotonin, dopamine, and norepinephrine, aquatic invertebrates who possess transporters and receptors sensitive to activation by these pharmaceuticals are potentially affected by them. We review the various types of antidepressants, their occurrence and concentrations in aquatic environments, and the actions of neurohormones modulated by antidepressants in molluscs and crustaceans. Recent studies on the effects of antidepressants on these two important groups show that molluscan reproductive and locomotory systems are affected by antidepressants at environmentally relevant concentrations. In particular, antidepressants affect spawning and larval release in bivalves and disrupt locomotion and reduce fecundity in snails. In crustaceans, antidepressants affect freshwater amphipod activity patterns, marine amphipod photo- and geotactic behavior, crayfish aggression, and daphnid reproduction and development. We note with interest the occurrence of non-monotonic dose responses curves in many studies on effects of antidepressants on aquatic animals, often with effects at low concentrations, but not at higher concentrations, and we suggest future experiments consider testing a broader range of concentrations. Furthermore, we consider invertebrate immune responses, genomic and transcriptomic sequencing of invertebrate genes, and the ever-present and overwhelming question of how contaminant mixtures could affect the action of neurohormones as topics for future study. In addressing the question, if antidepressants affect aquatic invertebrates at concentrations currently found in the environment, there is strong evidence to suggest the answer is yes. Furthermore, the examples highlighted in this review provide compelling evidence that the effects could be quite multifaceted across a variety of biological systems.

show abstract

Serotonin Influences Locomotion in the Nudibranch Mollusc Melibe leonina

Cited by 10 publications

References 28 publications

Effects of the Antidepressants Citalopram and Venlafaxine on the Big Ramshorn Snail (Planorbarius corneus)

Effects of the Antidepressants Citalopram and Venlafaxine on the Big Ramshorn Snail (Planorbarius corneus)

Serotonin in Animal Cognition and Behavior

The biological effects of antidepressants on the molluscs and crustaceans: A review

Contact Info

Product

Resources

About