Serotonin-induced platelet calcium mobilization is enhanced in mania

Altered 5-HT-Induced Calcium Response in the Presence of Staurosporine in Blood Platelets from Bipolar Disorder Patients

“…Other researchers (Mikuni et al, 1992;Eckert et al, 1993;Okamoto et al, 1994;Tomiyoshi et al, 1999) have obtained similar findings. The enhancement in Ca response to 5-HT continues after remission, which indicates that this response may be a trait-dependent rather than a statedependent marker (Kusumi et al, 1994;Tomiyoshi et al, 1999).…”

Serotonin 5-HT2A receptor gene polymorphism, 5-HT2A receptor function and personality traits in healthy subjects: a negative study

“…By measuring 5-HTinduced intraplatelet calcium (Ca) mobilization, we have already indicated that the 5-HT2A receptor function is increased in some types of depression such as bipolar disorder and melancholic major depression compared to normal controls, and that the enhanced Ca response is trait dependent (Kusumi et al, 1991b;. Although these findings were confirmed by many studies (Mikuni et al, 1992;Eckert et al, 1993;Okamoto et al, 1994;Konopka et al, 1996;Tomiyoshi et al, 1999), it was found that the range of the 5-HT-stimulated Ca response in normal subjects was widely distributed and fairly overlapped with that in depressed patients. Since the relationship between some personality traits and depression has previously been implicated in various psychopathological studies, we postulated that the 5-HT-induced Ca mobilization might be related with some personality traits that are involved in the vulnerability of affective disorders.…”

Treatment Response in Depressed Patients with Enhanced Ca Mobilization Stimulated by Serotonin

“…Although these findings were confirmed by several studies (Mikuni et al 1992;Eckert et al 1993;Okamoto et al 1994;Konopka et al 1996;Tomiyoshi et al 1999), there has not been any follow-up study of this parameter except our previous report (Kusumi et al 1994), which suggested that the enhanced Ca response is not state dependent, but trait dependent. Assuming that this parameter might be some predictor of treatment response in depressed patients, in this study, we examined the relationship between clinical improvement and pretreatment value of the 5-HT-induced intraplatelet Ca response in patients with bipolar disorders and major depressive disorders.…”

“…As for the basal Ca concentration, most researchers, except Dubovsky et al (1991) and Konopka et al (1996), have shown that there is no significant difference between depressed patients and normal controls (Kusumi et al 1991b(Kusumi et al , 1994Mikuni et al 1992;Eckert et al 1993;Okamoto et al 1994;Bothwell et al 1994;Tomoyoshi et al 1999). In this study, this finding was reconfirmed when comparing by DSM-IV subtype (Table 1).…”