Serotonin in anxiety and panic: Contributions of the elevated T-maze

Zangrossi, Hélio; Graeff, Frederico Guilherme

doi:10.1016/j.neubiorev.2014.03.007

Cited by 115 publications

(59 citation statements)

References 114 publications

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“…Specifically, using optogenetic techniques, they demonstrated that stimulation of a select population of BLA cells projecting to CeL produced anxiolytic actions, presumably via a BLA‐induced activation of GABAergic CeL cells and the consequent inhibition of CeM output neurons. Interestingly, however, the overall (or nonspecific) activation of BLA neurons was found to be anxiogenic, which is consistent with previously discussed reports (Vicente and Zangrossi, ; Zangrossi and Graeff, ).…”

Section: Discussionsupporting

confidence: 92%

Pattern of distribution of serotonergic fibers to the amygdala and extended amygdala in the rat

Linley

Olucha-Bordonau

Vertes

2016

J of Comparative Neurology

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As well recognized, serotonergic (5-HT) fibers distribute widely throughout the forebrain, including the amygdala. Although a few reports have examined the 5-HT innervation of select nuclei of the amygdala in the rat, no previous report has described overall 5-HT projections to the amygdala in the rat. Using immunostaining for the serotonin transporter, SERT, we describe the complete pattern of distribution of 5-HT fibers to the amygdala (proper) and to the extended amygdala in the rat. Based on its ontogenetic origins, the amygdalar was subdivided into two major parts: pallial and subpallial components, with the pallial component further divided into superficial and deep nuclei (Olucha-Bordonau et al., 2015). SERT+ fibers were shown to distribute moderately to densely to the deep and cortical pallial nuclei, but, by contrast, lightly to the subpallial nuclei. Specifically, (1) of the deep pallial nuclei, the lateral, basolateral and basomedial nuclei contained a very dense concentration of 5-HT fibers; (2) of the cortical pallial nuclei, the anterior cortical and amygdala-cortical transition zone, rostrally, and the posteromedial and posterolateral nuclei, caudally, contained a moderate concentration of 5-HT fibers; and (3) of the subpallial nuclei, the anterior nuclei and the rostral part of the medial (Me) nuclei contained a moderate concentration of 5-HT fibers, whereas caudal regions of Me as well as the central nuclei and the intercalated nuclei contained a sparse/light concentration of 5-HT fibers. Regarding the extended amygdala (primarily the bed nucleus of stria terminalis, BST), on the whole, the BST contained moderate numbers of 5-HT fibers, spread fairly uniformly throughout BST. The findings were discussed with respect to a critical serotonergic influence on the amygdala, particularly on the basal complex, and extended amygdala in the control of states of fear and anxiety.

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Section: Discussionsupporting

confidence: 92%

Pattern of distribution of serotonergic fibers to the amygdala and extended amygdala in the rat

Linley

Olucha-Bordonau

Vertes

2016

J of Comparative Neurology

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“…It participates in several aspects of fear behavior, its lesion disrupts the acquisition of conditioned fear memory, and it is associated with specific subtypes of anxiety disorders (Avanzi and Brandão 2001; Avanzi et al 2003; Silva et al 2004; Borelli et al 2005; Dos Santos et al 2005; Ohmura et al 2014; Peters et al 2014; Zangrossi and Graeff 2014). Its functional alterations may also lead to disorders, such as schizophrenia or major depression (Aghajanian and Marek 2000; Hensler 2006).…”

Section: Introductionmentioning

confidence: 99%

Cellular architecture and transmitter phenotypes of neurons of the mouse median raphe region

et al. 2016

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The median raphe region (MRR, which consist of MR and paramedian raphe regions) plays a crucial role in regulating cortical as well as subcortical network activity and behavior, while its malfunctioning may lead to disorders, such as schizophrenia, major depression, or anxiety. Mouse MRR neurons are classically identified on the basis of their serotonin (5-HT), vesicular glutamate transporter type 3 (VGLUT3), and gamma-aminobutyric acid (GABA) contents; however, the exact cellular composition of MRR regarding transmitter phenotypes is still unknown. Using an unbiased stereological method, we found that in the MR, 8.5 % of the neurons were 5-HT, 26 % were VGLUT3, and 12.8 % were 5-HT and VGLUT3 positive; whereas 37.2 % of the neurons were GABAergic, and 14.4 % were triple negative. In the whole MRR, 2.1 % of the neurons were 5-HT, 7 % were VGLUT3, and 3.6 % were 5-HT and VGLUT3 positive; whereas 61 % of the neurons were GABAergic. Surprisingly, 25.4 % of the neurons were triple negative and were only positive for the neuronal marker NeuN. PET-1/ePET-Cre transgenic mouse lines are widely used to specifically manipulate only 5-HT containing neurons. Interestingly, however, using the ePET-Cre transgenic mice, we found that far more VGLUT3 positive cells expressed ePET than 5-HT positive cells, and about 38 % of the ePET cells contained only VGLUT3, while more than 30 % of 5-HT cells were ePET negative. These data should facilitate the reinterpretation of PET-1/ePET related data in the literature and the identification of the functional role of a putatively new type of triple-negative neuron in the MRR.

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“…More particularly, the biogenic amines serotonin (5-HT) and dopamine (DA) have been involved in fear responses and anxiety in mammals (Bonhomme and Esposito, 1998;Nutt, 2001;Graeff and Zangrossi, 2010;Canteras and Graeff, 2014;Fossat et al, 2014;Zangrossi and Graeff, 2014). In crayfish and other decapods, 5-HT has been shown to control the stress response by raising secretion of crustacean hyperglycemic hormones (CHHs), leading to an increase in blood glucose (Lorenzon et al, 2005;Fossat et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Serotonin, but not dopamine, controls stress response and anxiety-like behavior in crayfish, Procambarus clarkii.

Fossat

Bacqué-Cazenave

Deurwaerdère

et al. 2015

Journal of Experimental Biology

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In the animal kingdom, biogenic amines are widespread modulators of the nervous system that frequently interact to control mood. Our previous investigations in crayfish (Procambarus clarkii) have established that stress induces changes in brain serotonin (5-HT) concentrations that are responsible for the appearance of anxiety-like behavior (ALB). Here, we further analyze the roles of 5-HT and another biogenic amine, dopamine (DA), on the crayfish response to stress. We show that the intensity of crayfish ALB depends on the intensity of stressful stimulation and is associated with increased concentrations of 5-HT in the brain. These 5-HT levels were significantly correlated, before, as well as after stress, with those of DA, which were approximately 3-to 5-times less abundant. However, whereas the degree of ALB was clearly correlated with brain 5-HT concentrations, it was not significantly correlated with DA. Moreover, in contrast to injections of 5-HT, DA injections were not able to elicit a stress response or ALB. In addition, 5-HT and DA levels were not modified by treatment with the anxiolytic chlordiazepoxide, confirming that suppression of ALB by this GABA-A receptor ligand acts downstream and is independent of changes in crayfish bioamine levels. Our study also provides evidence that the anxiogenic effect of 5-HT injections can be prevented by a preliminary injection of 5-HT antagonists. Altogether, our results emphasize that the rises in brain concentrations of 5-HT, but not DA, play a role in controlling the induction and the intensity of crayfish ALB.

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Serotonin in anxiety and panic: Contributions of the elevated T-maze

Cited by 115 publications

References 114 publications

Pattern of distribution of serotonergic fibers to the amygdala and extended amygdala in the rat

Pattern of distribution of serotonergic fibers to the amygdala and extended amygdala in the rat

Cellular architecture and transmitter phenotypes of neurons of the mouse median raphe region

Serotonin, but not dopamine, controls stress response and anxiety-like behavior in crayfish, Procambarus clarkii.

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