Serotonin-immunoreactive cells of peculiar shape in the urethral epithelium of the human penis

Iwanaga, Toshihiko; Hanyu, Shugo; Fujita, Tsuneo

doi:10.1007/bf00215417

Cited by 16 publications

(15 citation statements)

References 13 publications

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“…On the other hand, Lendon et al (1976) claimed that, in humans, no serotonin-fluorescent cells occurred distal to the point of the entry of the ejaculatory ducts in the male or in the distal one-third of the female urethra. Our previous immunohistochemical study (Iwanaga et al, 1987) recognized numerous serotonin cells dispersed in the human penile urethra. Forsberg et al (1964) demonstrated serotonin-fluorescent cells in the vestibular and lower vaginal epithelia of rabbits, whereas no studies seem available concerning the paraneurons in the vestibule and vagina in other mammals.…”

Section: Introductionmentioning

confidence: 85%

“…Fluorescence histochemistry for monoamines has revealed that serotonin is one of the main contents in the paraneurons in the cat urethra (Owman et al, 1971) and guinea pig urethra and prostate (Haanson et al, 1974). Serotonin-containing paraneurons have been also demonstrated immunohistochemically in the human prostatic urethra and prostate by Fetissof et al (1983) and in the human penile urethra and paraurethral gland by Iwanaga et al (1987).…”

Section: Introductionmentioning

confidence: 99%

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Distribution of serotonin‐immunoreactive paraneurons in the lower urinary tract of dogs

et al. 1987

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Morphological and quantitative studies were made on serotonin-containing paraneurons throughout the lower urinary tract in male and female dogs. Using an anti-serotonin antiserum, the cells were consistently demonstrated to be dispersed in the epithelium from the vesico-urethral junction to the external urethral ostium. They occurred most frequently in the urethra proximal to the urogenital diaphragm in both sexes. The total number of the serotonin-immunoreactive cells in the urethra was estimated to be 36.2 X 10(4) (SD 9.9 X 10(4] in the male (n = 3) and 15.6 X 10(4) (SD 2.1 X 10(4] in the female (n = 3). Besides the urethra, the prostate and vaginal vestibule contained several serotonin-immunoreactive cells. The urethral serotonin cells were basically bipolar basal-granulated cells that extended the basal cytoplasm to the basement membrane and reached the lumen with an apical process. Modified cell shapes were, however, also frequent, and included bifurcated apical and/or basal processes or a laterally directed basal process. Occasional serotonin cells possessed a threadlike basal process with varicosities and a terminal bouton, reminiscent of a neuronal process. Immunoreactivity for chromogranin A, a carrier protein common to endocrine paraneurons, was demonstrated in all of the urethral serotonin cells. The chromogranin A-immunoreactive granules accumulated more densely in the basal and perinuclear regions of the cell. It is hypothesized that the serotonin-immunopositive paraneurons may receive chemical and/or physical information from urine and, in response to it, secrete serotonin which presumably causes the contraction of the musculature of the urethra.

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Section: Introductionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Distribution of serotonin‐immunoreactive paraneurons in the lower urinary tract of dogs

et al. 1987

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“…Populations of specialized cells have been identified in the urethral epithelium of several mammalian species, including humans . Electron microscopy studies identified cells with apical microvilli and basal secretory granules expressing acetylcholine (ACh) and serotonin (5‐HT) .…”

Section: Introductionmentioning

confidence: 99%

“…Populations of specialized cells have been identified in the urethral epithelium of several mammalian species, 8,[12][13][14][15] including humans. 16,17 Electron microscopy studies identified cells with apical microvilli and basal secretory granules expressing acetylcholine (ACh) and serotonin (5-HT). 17,18 ACh was shown to activate muscarinic receptors on subepithelial sensory fibers 18,19 while 5-HT bind 5-HT 2 and 5-HT 3 receptors on urethral sensory fibers leading to the activation of spinal neurons.…”

Section: Introductionmentioning

confidence: 99%

Evidence for an urethro‐vesical crosstalk mediated by serotonin

Coelho

Oliveira

Cavaleiro

et al. 2018

Neurourology and Urodynamics

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“…The urethral epithelium in human males and females; and in some mammals contains numerous "clear cells" (FEYRTER, 1951(FEYRTER, , 1953, most of which are chromaffin and contain serotonin (DIxON et al, 1973;HAKANSON et al, 1974;IWANAGA et al, 1987). HANYU et al (1987) reported the frequency of the occurrence of the serotonin-immunoreactive cells in the canine urethra of both sexes.…”

Section: Endocrine Cellsmentioning

confidence: 99%

Calcitonin Gene-Related Peptide (CGRP)-Immunoreactive Nerve Terminals in the Whole Mount Preparations of the Dog Urethra.

Tamaki

Iwanaga

Takeda

et al. 1992

Archives of Histology and Cytology

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Summary. To visualize the entire shape of the intraepithelial nerve fibers, whole mount preparations of the dog urethra were produced and immunostained with an antiserum against CGRP, one of the predominant substances contained in the nerves.The immunoreactive nerves in the lamina propria were smooth (non-beaded) in appearance and weak in immunoreaction. Within the epithelium, they displayed typical beaded profiles and were intense in immunoreaction. The intraepithelial fibers branched and wound into an extensive network with wide meshes ("reticular terminal"). The bead-like swellings included large ones resembling Herring bodies in hypophyseal neurosecretory fibers.Another type of nerve terminal, consisting of fine and weakly immunopositive fibers, was also found in the epithelium. These branched in dendritic or in dense bouquetlike fashion, occupying smaller areas ("bouquet-like terminals). Vesicular swellings often characterized these terminals, though they were smaller and more uniform in size and far less in their amount of immunoreactive substance than were the swellings in the reticular terminals. Both types of nerve terminals originated from the same nerve trunk.The connection between the reticular and bouquetlike terminals, which may presumably represent secretory and receptive parts, respectively, morphologically supports the possible occurrence of an axon reflex in the urethral CGRP neurons.Our whole mount preparations, when doubly stained with CGRP and serotonin antibodies, further revealed the CGRP-positive reticular terminals being closely associated with serotonin-or CGRP-immunoreactive paraneurons dispersed in the epithelium.

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Serotonin-immunoreactive cells of peculiar shape in the urethral epithelium of the human penis

Cited by 16 publications

References 13 publications

Distribution of serotonin‐immunoreactive paraneurons in the lower urinary tract of dogs

Distribution of serotonin‐immunoreactive paraneurons in the lower urinary tract of dogs

Evidence for an urethro‐vesical crosstalk mediated by serotonin

Calcitonin Gene-Related Peptide (CGRP)-Immunoreactive Nerve Terminals in the Whole Mount Preparations of the Dog Urethra.

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