Serotonin depletion eliminates sex differences with respect to context-conditioned immobility in rat

Pettersson, Robert; Hagsäter, Sven Melker; Eriksson, Elias

doi:10.1007/s00213-016-4246-5

Cited by 16 publications

(11 citation statements)

References 51 publications

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“…Our findings are in agreement with previous reports of similar experiments using Wistar and Lewis rats (Cossio et al, 2016; Maeng et al, 2015; Pryce et al, 1999; Zhao et al, 2018). On the other hand, they contrast with results of other studies using these tests in which males were reported to be more responsive than females (de Jongh et al, 2005; Gresack et al, 2009; Maren et al, 1994; Pettersson et al, 2016). This might reflect the rather different protocols as well as strains of rat used in the latter studies.…”

Section: Discussioncontrasting

confidence: 99%

Short-term, low-dose fluoxetine prevents oestrous cycle-linked increase in anxiety-like behaviour in female rats

et al. 2019

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Background and aims: We sought a robust behavioural test that evoked increased anxiety-like behaviour during the late dioestrus phase of the oestrous cycle (similar to the premenstrual period in women) and tested whether this could be prevented by acute low-dose fluoxetine (FLX). Methods: Female Wistar rats in different stages of their cycle were exposed to four different tests of anxiety-like behaviour. Results: No oestrous cycle differences were detected in fear potentiated startle or conditioned freezing to an aversive context. In a light switch-off test where rats move from one compartment of a shuttle-box to the other to turn off an aversive light, females displayed enhanced responding in late dioestrus. During isolation restraint stress females in late dioestrus emitted three times more 22 kHz ultrasound vocalisations (USV) than at other cycle stages. Using the USV test, short-term administration of low-dose FLX (1.75 mg kg−1, i.p.) designed to blunt the sharp fall in brain allopregnanolone concentration during late dioestrus but without affecting 5-HT systems, prevented the increase in isolation stress-evoked USVs. Conclusions: The light switch-off and isolation restraint-induced USV tests evoke unconditioned adverse emotional responses that are ethologically relevant and sensitive to oestrous cycle stage. The USV test fulfils many criteria required of a model for premenstrual syndrome in women. Using the USV test, short-term administration of FLX to increase brain allopregnanolone concentration without affecting 5-HT systems prevented the increased USV responding in late dioestrus. Short-term low-dose FLX treatment may have potential to alleviate development of adverse premenstrual symptoms in women.

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Section: Discussioncontrasting

confidence: 99%

Short-term, low-dose fluoxetine prevents oestrous cycle-linked increase in anxiety-like behaviour in female rats

et al. 2019

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“…These results are consistent with recent findings (Day et al 2016), although in contrast to studies on fear discrimination in humans where females show less discrimination than males (Gamwell et al 2015;Lornsdorf et al 2015). Females also displayed lower contextual freezing, consistent with several prior reports in rodents (Pryce et al 1999;Daviu et al 2014;Pettersson et al 2016, although see Keiser et al 2017. When this difference in contextual freezing was subtracted from freezing to each cues, there was a larger difference in freezing to CS+, whereas the main difference in the uncorrected data was primarily in freezing to the CS−.…”

supporting

confidence: 93%

Sex differences in fear discrimination do not manifest as differences in conditioned inhibition

et al. 2017

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Distinguishing safety from danger is necessary for survival, but is aberrant in individuals with post-traumatic stress disorder (PTSD). While PTSD is more prevalent in women than men, research on sex differences in safety learning is limited. Here, female rats demonstrated greater fear discrimination than males in a CS+/CS- paradigm. To determine if this sex difference transferred to fear inhibition, rats were tested for conditioned inhibition in a summation test with the CS+ and CS- presented in compound; no sex difference emerged. The results suggest sex differences in the neural mechanisms of discrimination learning but not recall of a fear inhibitor.

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“…Considering other hypotheses for the pathophysiology of depression, especially the monoamine hypothesis, we therefore used the tryptophan hydroxylase inhibitor PCPA to deplete serotonin . The C57BL/6J mice were first injected with PCPA (300 mg/kg) and then injected with TSG (60 mg/kg), and followed by the FST or TST.…”

Section: Resultsmentioning

confidence: 99%

Antidepressant‐like effects of tetrahydroxystilbene glucoside in mice: Involvement of BDNF signaling cascade in the hippocampus

et al. 2017

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Serotonin depletion eliminates sex differences with respect to context-conditioned immobility in rat

Abstract: The greater display of context-conditioned immobility in males compared with females appears to be serotonin-dependent.

Cited by 16 publications

References 51 publications

Short-term, low-dose fluoxetine prevents oestrous cycle-linked increase in anxiety-like behaviour in female rats

Short-term, low-dose fluoxetine prevents oestrous cycle-linked increase in anxiety-like behaviour in female rats

Sex differences in fear discrimination do not manifest as differences in conditioned inhibition

Antidepressant‐like effects of tetrahydroxystilbene glucoside in mice: Involvement of BDNF signaling cascade in the hippocampus

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