Serotonin‐deficient neonatal mice are not protected against the development of experimental bronchopulmonary dysplasia or pulmonary hypertension

Roberts, Danielle S.; Sherlock, Laura; Posey, Janelle; Archambault, Jamie L.; Nozik, Eva S.; Delaney, Cassidy

doi:10.14814/phy2.15482

Cited by 4 publications

(1 citation statement)

References 57 publications

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“…Because both TPH1 and 5-HT 2A receptor expression are increased in experimental PH and the pharmacologic blockade of the 5-HT 2A receptor is protective against the development of experimental PH, we hypothesized that genetic depletion of TPH1 is also protective against PH. Interestingly, this was not the case [127]. Contrary to our hypothesis, circulating and pulmonary 5-HT is decreased in hypoxic wild-type mice compared to the controls.…”

Section: Serotonin In Neonatal Pulmonary Hypertensioncontrasting

confidence: 99%

A Review of Serotonin in the Developing Lung and Neonatal Pulmonary Hypertension

Archambault,

Delaney

2023

Biomedicines

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Serotonin (5-HT) is a bioamine that has been implicated in the pathogenesis of pulmonary hypertension (PH). The lung serves as an important site of 5-HT synthesis, uptake, and metabolism with signaling primarily regulated by tryptophan hydroxylase (TPH), the 5-HT transporter (SERT), and numerous unique 5-HT receptors. The 5-HT hypothesis of PH was first proposed in the 1960s and, since that time, preclinical and clinical studies have worked to elucidate the role of 5-HT in adult PH. Over the past several decades, accumulating evidence from both clinical and preclinical studies has suggested that the 5-HT signaling pathway may play an important role in neonatal cardiopulmonary transition and the development of PH in newborns. The expression of TPH, SERT, and the 5-HT receptors is developmentally regulated, with alterations resulting in pulmonary vasoconstriction and pulmonary vascular remodeling. However, much remains unknown about the role of 5-HT in the developing and newborn lung. The purpose of this review is to discuss the implications of 5-HT on fetal and neonatal pulmonary circulation and summarize the existing preclinical and clinical literature on 5-HT in neonatal PH.

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Section: Serotonin In Neonatal Pulmonary Hypertensioncontrasting

confidence: 99%

A Review of Serotonin in the Developing Lung and Neonatal Pulmonary Hypertension

Archambault,

Delaney

2023

Biomedicines

Self Cite

View full text Add to dashboard Cite

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Neonatal Thrombocytopenia: Factors Associated With the Platelet Count Increment Following Platelet Transfusion

Christensen¹,

Bahr²,

Davenport³

et al. 2023

The Journal of Pediatrics

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Relationship between Urine Serotonin and Persistent Pulmonary Hypertension of the Newborn

Archambault,

Hernandez,

Nozik

et al. 2025

The Journal of Pediatrics

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Serotonin‐deficient neonatal mice are not protected against the development of experimental bronchopulmonary dysplasia or pulmonary hypertension

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 4 publications

References 57 publications

A Review of Serotonin in the Developing Lung and Neonatal Pulmonary Hypertension

A Review of Serotonin in the Developing Lung and Neonatal Pulmonary Hypertension

Neonatal Thrombocytopenia: Factors Associated With the Platelet Count Increment Following Platelet Transfusion

Relationship between Urine Serotonin and Persistent Pulmonary Hypertension of the Newborn

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