Serotonin and tolerance to delay of reward in rats

Bizot, Jean-Charles; Bihan, Claudine Le; Puech, Alain J.; Hamon, Michel; Thiébot, Marie-Hélène

doi:10.1007/pl00005485

Cited by 223 publications

(154 citation statements)

References 2 publications

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“…However, the behavioral effects of the acute systemic administration of SSRIs on impulsive behavior were not consistent. For example, some studies showed the administration of SSRIs increased the selection rate of a large, delayed reward over a small, immediate reward, indicating a decrease in impulsive choice (Bizot et al, 1988(Bizot et al, , 1999. By contrast, a lack of effect has also been reported (Evenden and Ryan, 1996).…”

Section: Discussionmentioning

confidence: 99%

Activation of Dorsal Raphe Serotonin Neurons Is Necessary for Waiting for Delayed Rewards

Miyazaki

Doya²

2012

Journal of Neuroscience

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The forebrain serotonergic system is a crucial component in the control of impulsive behaviors. We previously reported that the activity of serotonin neurons in the midbrain dorsal raphe nucleus increased when rats performed a task that required them to wait for delayed rewards. However, the causal relationship between serotonin neural activity and the tolerance for the delayed reward remained unclear. Here, we test whether the inhibition of serotonin neural activity by the local application of the 5-HT 1A receptor agonist 8-hydroxy-2-(din-propylamino) tetralin in the dorsal raphe nucleus impairs rats' tolerance for delayed rewards. Rats performed a sequential food-water navigation task that required them to visit food and water sites alternately via a tone site to get rewards at both sites after delays. During the short (2 s) delayed reward condition, the inhibition of serotonin neural activity did not significantly influence the numbers of reward choice errors (nosepoke at an incorrect reward site following a conditioned reinforcer tone), reward wait errors (failure to wait for the delayed rewards), or total trials (sum of reward choice errors, reward wait errors, and acquired rewards). By contrast, during the long (7-11 s) delayed reward condition, the number of wait errors significantly increased while the numbers of total trials and choice errors did not significantlychange.Theseresultsindicatethattheactivationofdorsalrapheserotoninneuronsisnecessaryforwaitingforlongdelayedrewards and suggest that elevated serotonin activity facilitates waiting behavior when there is the prospect of forthcoming rewards.

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Section: Discussionmentioning

confidence: 99%

Activation of Dorsal Raphe Serotonin Neurons Is Necessary for Waiting for Delayed Rewards

Miyazaki

Doya²

2012

Journal of Neuroscience

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“…Central 5-HT manipulations also affect the ability to wait for reinforcement following response in impulsive-choice paradigms, although the evidence is less clear cut than for tests in which responding itself must be withheld. Although some studies have found direct effects of 5-HT manipulations on impulsive choice (Bizot et al, 1999;Mobini et al, 2000a, b;Schweighofer et al, 2008;Wogar et al, 1993), others found no such effects (Crean et al, 2002;Tanaka et al, 2007;Winstanley et al, 2004a). This discrepancy has been attributed to subtle differences between tasks.…”

Section: -Ht Depletion Impairs Waiting But Not Ssrt Dm Eagle Et Almentioning

confidence: 99%

Serotonin Depletion Impairs Waiting but not Stop-Signal Reaction Time in Rats: Implications for Theories of the Role of 5-HT in Behavioral Inhibition

Eagle

Lehmann

Theobald

et al. 2008

Neuropsychopharmacol

121

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Central serotonin (5-HT) function is thought to be a critical component of behavioral inhibition and impulse control. However, in recent clinical studies, 5-HT manipulations failed to affect stop-signal reaction time (SSRT), which is a fundamental process in behavioral inhibition. We investigated the effect of central 5-HT depletion (intracerebroventricular 5,7-dihydroxytryptamine) in rats on two aspects of behavioral inhibition, SSRT and 'waiting', using the stop-signal task. 5-HT depletion had no effects on SSRT or any other primary measure on the stop-signal task. However, within the same task, there was a deficit in 'waiting' in 5-HT-depleted rats when they were required to withhold from responding in the terminal element of the stop-signal task for an extended period. D-Amphetamine had dosedependent, but not 5-HT-dependent effects on SSRT. Conversely, the dose that tended to improve, or decrease, SSRT (0.3 mg/kg) impaired the ability to wait, again independently of 5-HT manipulation. These findings suggest that SSRT and 'waiting' are distinct measures of behavioral inhibition, and show that 5-HT is critical for some forms of behavioral inhibition but not others. This has significant implications for the treatment of conditions such as attention deficit and hyperactivity disorder, substance abuse, and affective disorders, in which inhibitory and impulse-control deficits are common.

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“…Briefly, studies with experimental rodents have shown that depleting forebrain 5-HT leads to consistent choices of small, immediate rewards over large, delayed rewards, possibly reflecting hypersensitivity to the delay (Wogar et al, 1993;Mobini et al, 2000;Cardinal et al, 2004;Denk et al, 2005;Cardinal, 2006) (but see Winstanley et al, 2003). Conversely, increasing 5-HT function with the 5-HT indirect agonist fenfluramine decreases impulsive choice (Poulos et al, 1996;Bizot et al, 1999); and 5-HT efflux was found to be increased in the medial PFC (though not OFC) during delay discounting, as measured with microdialysis (Winstanley et al, 2006b). In line with this proposal and animal work, Schweighofer et al (2008) have recently shown that ATD also steepens delayed reward discounting in humans, resulting in increased choice of the more immediate small rewards (but see Crean et al (2002), who used hypothetical rather than experiential choices).…”

Section: Intertemporal Choicementioning

confidence: 99%

Serotonin and Dopamine: Unifying Affective, Activational, and Decision Functions

Cools

Nakamura²,

Daw³

2010

Neuropsychopharmacol

406

369

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Serotonin, like dopamine (DA), has long been implicated in adaptive behavior, including decision making and reinforcement learning. However, although the two neuromodulators are tightly related and have a similar degree of functional importance, compared with DA, we have a much less specific understanding about the mechanisms by which serotonin affects behavior. Here, we draw on recent work on computational models of dopaminergic function to suggest a framework by which many of the seemingly diverse functions associated with both DA and serotoninFcomprising both affective and activational ones, as well as a number of other functions not overtly related to eitherFcan be seen as consequences of a single root mechanism.

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Serotonin and tolerance to delay of reward in rats

Cited by 223 publications

References 2 publications

Activation of Dorsal Raphe Serotonin Neurons Is Necessary for Waiting for Delayed Rewards

Activation of Dorsal Raphe Serotonin Neurons Is Necessary for Waiting for Delayed Rewards

Serotonin Depletion Impairs Waiting but not Stop-Signal Reaction Time in Rats: Implications for Theories of the Role of 5-HT in Behavioral Inhibition

Serotonin and Dopamine: Unifying Affective, Activational, and Decision Functions

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