Serotonin and sudden unexpected death in epilepsy

Petrucci, Alexandra N.; Joyal, Katelyn G.; Purnell, Benton S.; Buchanan, Gordon F.

doi:10.1016/j.expneurol.2019.113145

Cited by 69 publications

(74 citation statements)

References 249 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The copyright holder for this this version posted December 5, 2020. ; https://doi.org/10.1101/2020.12.04.410969 doi: bioRxiv preprint 3 behavior [8][9] , administration of 5-HTP significantly reduced the incidence of S-IRA by anticonvulsant effects in our models. The anticonvulsant effects of 5-HTP was basically consistent with other studies that activation of 5-HT neurons can reduce the severity of seizure [14][15][16] . Meanwhile, administration of KET reversed the lower incidence of S-IRA by 5-HTP with producing only partly anticonvulsant effects, which suggested that 5-HT2AR in brainstem may be a specific target to prevent S-IRA and SUDEP.…”

Section: Introductionsupporting

confidence: 91%

“…Currently, to our certain knowledge, respiratory dysfunction during seizures has been regarded as a leading mechanism of SUDEP. Some studies indicated that several selective serotonin ( 5-HT) reuptake inhibitors (SSRIs) can prevent S-IRA in DBA/1 mice evoked by generalized audiogenic seizures (AGSz) by elevating 5-HT levels in the synaptic cleft [13][14][15][16] .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Optogenetic activation of the serotonergic neural circuit between the dorsal raphe nucleus and pre-Bötzinger complex contributes to inhibition of seizure-induced respiratory arrest in the DBA/1 mouse SUDEP model

Shen

Lian

et al. 2020

Preprint

View full text Add to dashboard Cite

Sudden unexpected death in epilepsy (SUDEP) is the fatal cause leading to the death of epilepsy patients with anti-epileptic drug resistance. However, the underlying mechanism of SUDEP remains to be elusive. Our previous study demonstrated that enhancement of serotonin (5-HT) synthesis by intraperitoneal (IP) injection of 5-hydroxytryptophan in brain significantly reduced the incidence of seizure-induced respiratory arrest (S-IRA) in DBA/1 mice SUDEP models. Given that 5-HT2A receptor (5-HT2AR) acts an important role in mediating respiration system in brain, we hypothesized that 5-HT2AR is of great significance to modulate S-IRA and SUDEP. To test this hypothesis, we examined whether the decreased incidence S-IRA evoked by either acoustic stimulation or PTZ by blocking 5-HT2AR by administration with ketanserin (KET), a selective antagonist of 5HT2AR, in DBA/1 mice SUDEP models to test the role of 5-HT2AR modulating S-IRA. Our results suggested that the decreased incidence of S-IRA by 5-Hydroxytryptophan (5-HTP), a precursor for central nervous system (CNS) serotonin (5-HT) synthesis, was significantly reversed by IP and intracerebroventricularly (ICV) injection of ketanserin in our models. Thus, our data suggested that 5-HT2AR in the brain may be a potential and specific target to prevent SUDEP.

show abstract

Section: Introductionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Optogenetic activation of the serotonergic neural circuit between the dorsal raphe nucleus and pre-Bötzinger complex contributes to inhibition of seizure-induced respiratory arrest in the DBA/1 mouse SUDEP model

Shen

Lian

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Seizure-induced changes in serotonin have been seen in epilepsy patients. 6 Lower levels of cerebrospinal fluid 5-HIAA (5-hydroxyindoleacetic acid), which is an indicator of serotonergic activity, have been measured in patients with high lethality suicide attempts, compared to low lethality attempts. 7 The Taiwan study suggests higher lethality of suicide attempts in the patients with epilepsy and the REP cohort showed people with epilepsy were significantly more likely to reattempt suicide.…”

Section: Commentarymentioning

confidence: 99%

Adolescence and Epilepsy: The Perfect Storm for Suicidal Behavior

Nickels¹

2021

Epilepsy Curr

View full text Add to dashboard Cite

show abstract

“…Perhaps a similar stimulation paradigm could be employed to reduce seizure sequelae thought to increase risk for SUDEP, such as respiratory and autonomic dysregulation, in addition to impaired arousal. 4 , 10 That said, these details are not critical to begin testing whether similar stimulation can reduce postictal arousal impairment in patients. Indeed, this group has a clinical trial underway through the NIH Brain Initiative.…”

Section: Commentarymentioning

confidence: 99%