Serotonin and noradrenaline modulate chronic itch processing in mice

Miyahara, Yu; Funahashi, Hideki; Naono-Nakayama, Rumi; Haruta-Tsukamoto, Ayaka; Muroi, Chiyo; Kogoh, Yoichiro; Nishimori, Toshikazu; Ishida, Yoshiteru

doi:10.1016/j.ejphar.2020.173319

Cited by 9 publications

(4 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Historically, the noradrenergic and serotonergic pathways were known to alleviate thermal, mechanical, and neuropathic pain in animal models ( 32 ). However, recent research has indicated their involvement in acute ( 35 ) and chronic itch ( 36 ). A study by Koga et al ( 37 ) suggested that descending noradrenergic signalling inhibits acute and chronic itch, supporting our findings that yohimbine, an α1/α2 receptor antagonist, suppressed the anti-alloknesis activity of antipruritics.…”

Section: Discussionmentioning

confidence: 99%

Model of Chronic Itch in Aged Mice: Beneficial Effects of Drugs Affecting Descending Modulatory Systems

Kojima,

Komiya,

Honda

et al. 2024

Acta Derm Venereol

View full text Add to dashboard Cite

Pruritus in the elderly, particularly those cases without skin dryness or other identifiable causes, makes treatment challenging due to the lack of evidence regarding the therapeutic effects of antipruritics. This study proposes an age-related alloknesis mouse model for an evaluation system for such cases, and aimed to investigate the effectiveness and mechanisms of action of several drugs commonly used as antipruritics in Japan, utilizing this model. Mice 69–80 weeks old were used as aged mice, and the level of mechanical alloknesis was counted as the number of scratching behaviours in response to innocuous stimuli. Bepotastine, neurotropin, pregabalin, baricitinib, and abrocitinib were used as antipruritics, and yohimbine and methysergide as inhibitors of the descending inhibitory pathway. The findings suggest that mechanical alloknesis in aged mice is a suitable animal model for assessing pruritus in the elderly without xerosis, and pregabalin, neurotropin, baricitinib, and abrocitinib may be effective antipruritics in the elderly through activating both the noradrenergic and serotonergic descending inhibitory pathways. These findings may be useful for the selection of antipruritics for pruritus in the elderly without skin lesions or dryness.

show abstract

Section: Discussionmentioning

confidence: 99%

Model of Chronic Itch in Aged Mice: Beneficial Effects of Drugs Affecting Descending Modulatory Systems

Kojima,

Komiya,

Honda

et al. 2024

Acta Derm Venereol

View full text Add to dashboard Cite

show abstract

“…One of the stimuli for non-histaminergic pathways is serotonin. In patients with chronic and inflammatory diseases, serotonin is one of the substances that contributes to the induction of pruritus through its involvement in various pathways [ 40 , 41 ]. In this study we have induced pruritus by serotonin intradermal injection and have shown niclosamide reduce pruritus significantly in 5 mg/kg and 10 mg/kg furthermore we investigated the protein and gen expressions in skin, DRG, spine and brain tissues.…”

Section: Discussionmentioning

confidence: 99%

“Niclosamide: A potential antipruritic agent by modulating serotonin pathway through metabotropic glutamate receptors (mGluRs)”

Ebrahim Soltani,

Elahi,

Askari Rad

et al. 2024

Heliyon

View full text Add to dashboard Cite

“…For example, continuous theta burst transcranial magnetic stimulation over the contralateral primary somatosensory cortex has been shown to help reduce the intensity of histamine-induced pruritus. 58 Some antidepressants such as paroxetine, [59][60][61] and anticonvulsants such as gabapentin [62][63][64] and pregabalin 64,65 have also shown antipruritic effects. Therefore, an improved understanding of the pruritus regulation mechanism in the central nervous system of AD may help develop new drugs or physical therapies targeted at the physiological parameters underlying sensory hypersensitivity.…”

Section: Discussionmentioning

confidence: 99%

Higher‐order sensorimotor circuit of the whole‐brain functional network involved in pruritus regulation in atopic dermatitis

Wu,

Dai,

Hong

et al. 2023

Acad Dermatol Venereol

View full text Add to dashboard Cite

BackgroundLittle is known about the neural mechanisms underlying pruritus regulation in Atopic dermatitis (AD).ObjectiveTo investigate the functional changes of the resting‐state whole brain network of AD participants and the mechanisms by which they were involved in pruritus regulation.MethodBased on the functional magnetic resonance imaging data from 19 AD participants and 37 healthy controls (HC), a graph‐theoretical measure of degree centrality (DC) conjoined with a voxel‐level seed‐based functional connectivity (FC) method was used to identify abnormal higher‐order nodes and the functionally relevant circuit in AD participants compared to healthy controls (HC).ResultsOf 64 participants screened, 19 AD participants (12M/7F, median [IQR] age, 27 [14] years) and 36 HCs (13M/23F, median [IQR] age, 20 [1] years) were enrolled. DC values of the left superior frontal gyrus (LSFG) increased in AD participants and exhibited a negative correlation with the SCORAD score (r = −0.561, p = 0.012) compared with HC. In the FC analysis with LSFG as the seed, FC values of several sensory and motor regions increased in AD participants, highly overlapping with the anatomical distribution of the inferior fronto‐occipital fascicle (IFOF). AD participants with severe pruritus exhibited lower levels of DC (T = −2.316, p = 0.033) and FC between the LSFG and left insula (T = −2.203, p = 0.042) than those with mild‐to‐ moderate pruritus.Conclusions and RelevanceLSFG was involved in pruritus regulation in AD by forming a high‐order sensorimotor circuit through the IFOF, a white matter fascicle that proved to provide multimodal integration in motor control and sensory information processing. These results offer more mechanism‐guided treatment targets for severe pruritus in AD.

show abstract

Serotonin and noradrenaline modulate chronic itch processing in mice

Cited by 9 publications

References 32 publications

Model of Chronic Itch in Aged Mice: Beneficial Effects of Drugs Affecting Descending Modulatory Systems

Model of Chronic Itch in Aged Mice: Beneficial Effects of Drugs Affecting Descending Modulatory Systems

“Niclosamide: A potential antipruritic agent by modulating serotonin pathway through metabotropic glutamate receptors (mGluRs)”

Higher‐order sensorimotor circuit of the whole‐brain functional network involved in pruritus regulation in atopic dermatitis

Contact Info

Product

Resources

About