Serotonin and neuroplasticity – Links between molecular, functional and structural pathophysiology in depression

Kraus, Christoph; Ċastrén, Eero; Kasper, Siegfried

doi:10.1016/j.neubiorev.2017.03.007

Cited by 346 publications

(219 citation statements)

References 175 publications

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“…It is possible that the pro‐inflammatory catecholamines and hormones released from keratinocytes and dermal fibroblasts in response to tissue trauma remain elevated in a chronic wound, further perpetuating a state of delayed healing and chronic inflammation . There is growing evidence to suggest that dysregulation of catecholamine levels can contribute to altered cognition and depression …”

Section: Parallel Mechanisms Between Gut‐brain‐axis and Skin‐brain Axismentioning

confidence: 99%

Microbiome‐skin‐brain axis: A novel paradigm for cutaneous wounds

Hadian

Fregoso

Nguyen

et al. 2020

Wound Repair Regeneration

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Chronic wounds cause a significant burden on society financially, medically, and psychologically. Unfortunately, patients with nonhealing wounds often suffer from comorbidities that further compound their disability. Given the high rate of depressive symptoms experienced by patients with chronic wounds, further studies are needed to investigate the potentially linked pathophysiological changes in wounds and depression in order to improve patient care. The English literature on wound healing, inflammatory and microbial changes in chronic wounds and depression, and antiinflammatory and probiotic therapy was reviewed on PubMed. Chronic wound conditions and depression were demonstrated to share common pathologic features of dysregulated inflammation and altered microbiome, indicating a possible relationship. Furthermore, alternative treatment strategies such as immune-targeted and probiotic therapy showed promising potential by addressing both pathophysiological pathways. However, many existing studies are limited to a small study population, a cross-sectional design that does not establish temporality, or a wide range of confounding variables in the context of a highly complex and multifactorial disease process. Therefore, additional preclinical studies in suitable wound models, as well as larger clinical cohort studies and trials are necessary to elucidate the relationship between wound microbiome, healing, and depression, and ultimately guide the most effective therapeutic and management plan for chronic wound patients.

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Section: Parallel Mechanisms Between Gut‐brain‐axis and Skin‐brain Axismentioning

confidence: 99%

Microbiome‐skin‐brain axis: A novel paradigm for cutaneous wounds

Hadian

Fregoso

Nguyen

et al. 2020

Wound Repair Regeneration

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“…Serotonergic neurons in the raphe nuclei have widespread projections in the brain and are thus involved in a variety of brain functions, including regulation of mood and anxiety, the sleep‐wake cycle, reward, patience during decision making and sexual preference . Serotonergic projections from the dorsal and medial raphe nucleus innervate the OB densely, where they may modulate the initial representation of olfactory information .…”

Section: Feedback and Centrifugal Modulation Of The Obmentioning

confidence: 99%

Complex neural representation of odour information in the olfactory bulb

Rao

Zhou

et al. 2019

Acta Physiologica

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The most important task of the olfactory system is to generate a precise representation of odour information under different brain and behavioural states. As the first processing stage in the olfactory system and a crucial hub, the olfactory bulb plays a key role in the neural representation of odours, encoding odour identity, intensity and timing. Although the neural circuits and coding strategies used by the olfactory bulb for odour representation were initially identified in anaesthetized animals, a large number of recent studies focused on neural representation of odorants in the olfactory bulb in awake behaving animals. In this review, we discuss these recent findings, covering (a) the neural circuits for odour representation both within the olfactory bulb and the functional connections between the olfactory bulb and the higher order processing centres; (b) how related factors such as sniffing affect and shape the representation; (c) how the representation changes under different states;and (d) recent progress on the processing of temporal aspects of odour presentation in awake, behaving rodents. We highlight discussion of the current views and emerging proposals on the neural representation of odorants in the olfactory bulb. K E Y W O R D Sfeedback modulation, odour representation, olfactory bulb, physiological states, temporal information Anan Li and Diego Restrepo equally contributed to this work.

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“…8,9 The brain 5-HT system originates in the raphe nuclei, which projects widely 15 to innervate corticolimbic systems involved in stress, 16 anxiety, 17 depression 18 and cognitive function. 19 The levels of 5-HT are determined primarily by expression of the rate-limiting enzyme tryptophan hydroxylase-2 (TPH2); 20 by reuptake via the 5-HT transporter (5-HTT), which is the target of SSRI antidepressants; 21 and by the lev-els of 5-HT 1A autoreceptors that negatively regulate 5-HT neuronal firing. 22 Increased levels of 5-HT 1A autoreceptors, which would reduce 5-HT activity, are seen in depressed patients and in the raphe tissue of people with depression who died by suicide ( Fig.…”

Section: Introductionmentioning

confidence: 99%

Genetic, epigenetic and posttranscriptional mechanisms for treatment of major depression: the 5-HT1A receptor gene as a paradigm

Albert

François

Vahid-Ansari

2019

jpn

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Major depression and anxiety are highly prevalent and involve chronic dysregulation of serotonin, but they remain poorly understood. Here, we review novel transcriptional (genetic, epigenetic) and posttranscriptional (microRNA, alternative splicing) mechanisms implicated in mental illness, focusing on a key serotonin-related regulator, the serotonin 1A (5-HT 1A) receptor. Functional single-nucleotide polymorphisms and stress-induced DNA methylation of the 5-HT 1A promoter converge to differentially alter pre-and postsynaptic 5-HT 1A receptor expression associated with major depression and reduced therapeutic response to serotonergic antidepressants. Major depression is also associated with altered levels of splice factors and microRNA, posttranscriptional mechanisms that regulate RNA stability. The human 5-HT 1A 3′-untranslated region is alternatively spliced, removing microRNA sites and increasing 5-HT 1A expression, which is reduced in major depression and may be genotype-dependent. Thus, the 5-HT 1A receptor gene illustrates the convergence of genetic, epigenetic and posttranscriptional mechanisms in gene expression, neurodevelopment and neuroplasticity, and major depression. Understanding gene regulatory mechanisms could enhance the detection, categorization and personalized treatment of major depression.

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Serotonin and neuroplasticity – Links between molecular, functional and structural pathophysiology in depression

Cited by 346 publications

References 175 publications

Microbiome‐skin‐brain axis: A novel paradigm for cutaneous wounds

Microbiome‐skin‐brain axis: A novel paradigm for cutaneous wounds

Complex neural representation of odour information in the olfactory bulb

Genetic, epigenetic and posttranscriptional mechanisms for treatment of major depression: the 5-HT1A receptor gene as a paradigm

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