Serotonin and Ethanol Preference

McBride, William J.; Murphy, James M.; Lumeng, Lawrence; Li, Ting‐Kai

doi:10.1007/978-1-4899-1678-5_10

Cited by 94 publications

(23 citation statements)

References 59 publications

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“…Differences have also been reported in the dopamine systems of P/NP and HAD1/LAD1 rats (Gongwer et al, 1989;McBride et al, 1990;Katner and Weiss, 2001). Finally, differences have been reported in the serotonin systems of P rats compared with NP rats and in HAD1 rats compared with LAD1 rats (for reviews, see McBride et al, 1989McBride et al, , 1990. However, the limited number of studies and the direction of differences reported would not jpet.aspetjournals.org appear to be consistent with the reports of differences in working memory reported in this study, and the question of what cellular mechanisms may mediate the differences in working memory must rely on future studies.…”

Section: Discussionmentioning

confidence: 49%

Rats Selectively Bred for Ethanol Preference or Nonpreference Have Altered Working Memory

Wenger

Hall²

2010

J Pharmacol Exp Ther

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To examine whether the cognitive deficit observed in chronic alcoholics is because of the chronic exposure to alcohol or to a factor that contributes to the chronic alcohol use, working memory was evaluated under a delayed matching-to-position task in rats selectively bred for ethanol preference or nonpreference (iP/iNP, iHAD1/iLAD1, and iHAD2/iLAD2). Before the study on working memory, rats were studied under a progressive ratio schedule of food presentation to determine whether differences in motivation to respond for food existed between the alcohol-preferring and -nonpreferring strains. No such differences were observed. Under the delayed matching-toposition schedule, the length of the delay was titrated such that accuracy was maintained at approximately 80%, and the mean length of the delay for each experimental session provided a measure of working memory function. In two (iP/iNP and iHAD1/iLAD1) of the three pairs of selectively bred rats, nonpreference to ethanol was associated with better working memory performance. In the third pair of selectively bred rats (iHAD2/iLAD2), the relationship was reversed, with increased ethanol preference associated with better working memory function after saline administration. After ethanol administration, both the mean delay and the rate of responding were decreased in all six strains. Based upon an ED 50 analysis, there was little evidence of strain difference in sensitivity to ethanol on either parameter. Additional studies are needed to better understand the relationship between working memory and ethanol preference in these rats.Several studies have shown altered cognitive function, including memory disturbances, in humans who abuse ethanol and other drugs of abuse (Bowden et al., 2001;Rogers and Robbins, 2001;Block et al., 2002;Mintzer and Stitzer, 2002). However, it is not clear whether these differences existed before the abuse or whether the differences are the result of the abuse. One approach to answering this question is to examine working memory in alcohol-preferring (P) and alcohol-nonpreferring (NP) rats in both the absence and presence of ethanol.In 1974, Li and Lumeng began studies on an outbred strain of Wistar rats from the Walter Reed Army Institute of Research, Silver Spring, MD (Lumeng et al., 1977;Li et al., 1979Li et al., , 1981. These studies on gene-specific behavioral traits led to the development of the P and NP rat lines. Rats that were selected for breeding in the P line consumed in excess of 5 g/kg/day ethanol and demonstrated a better than 2:1 preference for ethanol over water. Rats selected for breeding in the NP line consumed less than 1.5 g/kg/day ethanol and did not exceed an ethanol-to-water preference of greater than 0.5:1. After approximately 30 generations of breeding, voluntary ethanol consumption of P rats averaged 9.2 Ϯ 0.4 g/kg/ day, whereas the NP rats consumed 1.9 Ϯ 0.7 g/kg/day. In addition, when given free access to food along with a choice of 10% ethanol or water, P rats consume 20 to 30% of their total calories ...

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Section: Discussionmentioning

confidence: 49%

Rats Selectively Bred for Ethanol Preference or Nonpreference Have Altered Working Memory

Wenger

Hall²

2010

J Pharmacol Exp Ther

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“…Using preference paradigms, pharmacological agents that inhibit 5-HT reuptake from the synapse reduce the voluntary consumption of ethanol solutions using the preference paradigm [142][143][144][145][146][147]. Knockout mice at the 5-HT transporter do, however, exhibit a general decrease in ethanol preference and consumption [148].…”

Section: Serotonin Reuptake Inhibitorsmentioning

confidence: 99%

Update on neuropharmacological treatments for alcoholism: Scientific basis and clinical findings

Johnson

2008

Biochemical Pharmacology

245

185

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The past decade has seen an expansion of research and knowledge on pharmacotherapy for the treatment of alcohol dependence. The Food and Drug Administration (FDA)-approved medications naltrexone and acamprosate have shown mixed results in clinical trials. Oral naltrexone and naltrexone depot formulations have generally demonstrated efficacy at treating alcohol dependence, but their treatment effect size is small, and more research is needed to compare the effects of different doses on drinking outcome. Acamprosate has demonstrated efficacy for treating alcohol dependence in European trials, but with a small effect size. In U.S. trials, acamprosate has not proved to be efficacious. Research continues to explore which types of alcohol-dependent individual would benefit the most from treatment with naltrexone or acamprosate. The combination of the two medications demonstrated efficacy for treating alcohol dependence in one European study but not in a multi-site U.S. study. Another FDA-approved medication, disulfiram, is an aversive agent that does not diminish craving for alcohol. Disulfiram is most effective when given to those who are highly compliant or who are receiving their medication under supervision. Of the non-approved medications, topiramate is among the most promising, with a medium effect size in clinical trials. Another promising medication, baclofen, has shown efficacy in small trials. Serotonergic agents such as selective serotonin reuptake inhibitors and the serotonin-3 receptor antagonist, ondansetron, appear to be efficacious only among certain genetic subtypes of alcoholic. As neuroscientific research progresses, other promising medications, as well as medication combinations, for treating alcohol dependence continue to be explored.

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“…Furthermore, a large body of literature has suggested that serotonin systems are important in EtOH preference (McBride and Li, 1998). For example, serotonergic systems in the dorsal raphe nucleus, with projections to the nucleus accumbens, have been proposed as one potential site of action mediating EtOH reward (McBride et al, 1989(McBride et al, , 1990). …”

Section: Utilization Of Place Conditioning For Understanding the Neurmentioning

confidence: 99%

Place Conditioning: What Does It Add to Our Understanding of Ethanol Reward?

Risinger

Cunningham

Bevins

et al. 2002

Alcoholism Clin & Exp Res

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This article describes the proceedings of a symposium at the 2001 RSA annual meeting in Montreal, Quebec, Canada. The cochairs were Fred O. Risinger and Christopher L. Cunningham. Presentations were as follows: (1) Place conditioning: understanding the motivational impact of stimuli, by Rick A. Bevins; (2) Role of historical factors in ethanol place conditioning, by Frank A. Holloway; (3) Ethanol place conditioning in mice: genetic and environmental influences, by Christopher L. Cunningham; and (4) Utilization of place conditioning for understanding the neuropharmacology of the rewarding effects of ethanol, by Fred O. Risinger.

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Serotonin and Ethanol Preference

Cited by 94 publications

References 59 publications

Rats Selectively Bred for Ethanol Preference or Nonpreference Have Altered Working Memory

Rats Selectively Bred for Ethanol Preference or Nonpreference Have Altered Working Memory

Update on neuropharmacological treatments for alcoholism: Scientific basis and clinical findings

Place Conditioning: What Does It Add to Our Understanding of Ethanol Reward?

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