Abstract:Manfred Göthert, who had served Naunyn-Schmiedeberg’s Arch Pharmacol as Managing Editor from 1998 to 2005, deceased in June 2019. His scientific oeuvre encompasses more than 20 types of presynaptic receptors, mostly on serotoninergic and noradrenergic neurones. He was the first to identify presynaptic receptors for somatostatin and ACTH and described many presynaptic receptors, known from animal preparations, also in human tissue. In particular, he elucidated the pharmacology of presynaptic 5-HT receptors. A s… Show more
“…Presynaptic CB 1 -Rs leading to inhibition of atrial NA release have also been identified in vitro in atrial tissue from humans [ 168 ], guinea pigs [ 177 ] and rats [ 178 ]. Presynaptic facilitatory CB 1 -Rs cannot be expected, since CB 1 -Rs are G i/o protein-coupled and only G s and G q protein-coupled receptors lead to facilitation of neurotransmitter release [ 208 ]. The other three receptor entities activated by THC, i.e., CB 2 , GPR18 [ 177 ] and GPR55, do not serve as presynaptic receptors.…”
The use of cannabis preparations has steadily increased. Although cannabis was traditionally assumed to only have mild vegetative side effects, it has become evident in recent years that severe cardiovascular complications can occur. Cannabis use has recently even been added to the risk factors for myocardial infarction. This review is dedicated to pathogenetic factors contributing to cannabis-related myocardial infarction. Tachycardia is highly important in this respect, and we provide evidence that activation of CB1 receptors in brain regions important for cardiovascular regulation and of presynaptic CB1 receptors on sympathetic and/or parasympathetic nerve fibers are involved. The prototypical factors for myocardial infarction, i.e., thrombus formation and coronary constriction, have also been considered, but there is little evidence that they play a decisive role. On the other hand, an increase in the formation of carboxyhemoglobin, impaired mitochondrial respiration, cardiotoxic reactions and tachyarrhythmias associated with the increased sympathetic tone are factors possibly intensifying myocardial infarction. A particularly important factor is that cannabis use is frequently accompanied by tobacco smoking. In conclusion, additional research is warranted to decipher the mechanisms involved, since cannabis use is being legalized increasingly and Δ9-tetrahydrocannabinol and its synthetic analogue nabilone are indicated for the treatment of various disease states.
“…Presynaptic CB 1 -Rs leading to inhibition of atrial NA release have also been identified in vitro in atrial tissue from humans [ 168 ], guinea pigs [ 177 ] and rats [ 178 ]. Presynaptic facilitatory CB 1 -Rs cannot be expected, since CB 1 -Rs are G i/o protein-coupled and only G s and G q protein-coupled receptors lead to facilitation of neurotransmitter release [ 208 ]. The other three receptor entities activated by THC, i.e., CB 2 , GPR18 [ 177 ] and GPR55, do not serve as presynaptic receptors.…”
The use of cannabis preparations has steadily increased. Although cannabis was traditionally assumed to only have mild vegetative side effects, it has become evident in recent years that severe cardiovascular complications can occur. Cannabis use has recently even been added to the risk factors for myocardial infarction. This review is dedicated to pathogenetic factors contributing to cannabis-related myocardial infarction. Tachycardia is highly important in this respect, and we provide evidence that activation of CB1 receptors in brain regions important for cardiovascular regulation and of presynaptic CB1 receptors on sympathetic and/or parasympathetic nerve fibers are involved. The prototypical factors for myocardial infarction, i.e., thrombus formation and coronary constriction, have also been considered, but there is little evidence that they play a decisive role. On the other hand, an increase in the formation of carboxyhemoglobin, impaired mitochondrial respiration, cardiotoxic reactions and tachyarrhythmias associated with the increased sympathetic tone are factors possibly intensifying myocardial infarction. A particularly important factor is that cannabis use is frequently accompanied by tobacco smoking. In conclusion, additional research is warranted to decipher the mechanisms involved, since cannabis use is being legalized increasingly and Δ9-tetrahydrocannabinol and its synthetic analogue nabilone are indicated for the treatment of various disease states.
“…These two scientists had a major impact on the major research topics of the journal for decades and the contribution of cities to the journal (see discussion below). Starke and Göthert also provided service to the journal as editors (Starke 1998 ; Bönisch et al 2021 ). Fig.…”
Section: Resultsmentioning
confidence: 99%
“…“Immunopharmacology” also rose to become the second most represented category in 2020. The contribution of neurotransmitter pharmacology to Naunyn–Schmiedeberg’s Archives of Pharmacology declined substantially over the decades, a major reason being that top contributors to the field retired or even passed away (Bönisch et al 2021 ). The importance of Naunyn–Schmiedeberg’s Archives of Pharmacology as a general mechanistic journal dedicated to molecular mechanisms of drug action also declined over the decades (“Introduction and Pharmacodynamics”).…”
Motivated by the 150-year anniversary of the Naunyn–Schmiedeberg’s Archives of Pharmacology in 2023, we studied the bibliometric development of the journal. We evaluated data from Editorial Reports, Clarivate, and Springer Nature databases. Several parameters representing the journal’s performance, such as the impact factor and social impact, were analyzed over the years. We analyzed the journal’s meta-data and wrote an algorithm to retrieve cities and countries of origin. We could see a decrease in publications from Germany and an increase in papers from Brazil, China, Egypt, and Iran during the last years. The decrease in publications from Germany is probably a zeitgeist effect because this country places a strong emphasis on high-impact factor papers for academic promotion and winning grants. Germany was the country with the most publications throughout the 100 most-cited articles. Most of these articles were published between 1970 and 1990, when neurotransmitters were the most published topic. Klaus Starke (Freiburg) and Manfred Göthert (Bonn) were prominent drivers of this field. The most common topics nowadays are “Drugs for the Treatment of Malignant Tumor Diseases” and “Immunopharmacology.” The internationality of the journal substantially increased after introduction of English as mandatory language in the 1970s. The journal also experienced substantial COVID-19 pandemic-related effects. This paper is not only of relevance for the field of pharmacology but for science in general in the sense that Naunyn–Schmiedeberg’s Archives of Pharmacology is a case study for profound changes in a traditional scientific journal, requiring permanent adjustment by editors, referees, publisher, authors, and readers alike. The development of the journal has been strongly influenced by historic and political developments, cultural attitudes (zeitgeist), language changes, global changes in research topics, and eminent individuals who published many papers in Naunyn–Schmiedeberg’s Archives of Pharmacology.
“…The discovery of the neurotransmitter serotonin, in 1949 by Maurice Rapport, began a branch of research about this molecule [ 8 , 9 , 10 , 11 ]. Abbreviated as 5-HT, for the molecule 5-hydroxytryptamine, serotonin is “involved in numerous diseases of the (central nervous system) CNS (e.g., depression, anxiety, schizophrenia, obsessive-compulsive disorders, addiction, Parkinson’s disease) and peripheral organs (e.g., gastrointestinal disorders, cardiac arrhythmia, hypertension)" [ 12 ].…”
Irritable bowel syndrome (IBS) is a gut-brain disorder involving alterations in intestinal sensitivity and motility. Currently, IBS has no cure, and treatment focuses on the management of symptoms. The diverse, and sometimes contradictory, collections of symptoms reported across the different subtypes of IBS make treatment, as well as diagnosis, difficult for physicians. All subtypes of IBS have one symptom in common: abdominal pain caused by differences in the level of visceral sensitivity. Though current research on this topic is in its infancy, some researchers have proven, through experimental studies, that 5-hydroxytryptamine (serotonin) receptor type 7 (5-HT7) affects both visceral sensitivity and smooth muscle tone in the bowel. Therefore, this review will be discussing the future possibility of alleviating abdominal pain in patients with IBS and related disorders by modulating the 5-HT7 receptor.
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