Serotonin (5‐hydroxytryptamine) Release and Uptake in Platelets From Healthy Persons and Migrainous Patients in Attack‐free Intervals

Dalsgaard‐Nielsen, T; Genefke, Inge Kemp

doi:10.1111/j.1526-4610.1974.hed1401026.x

Cited by 37 publications

(13 citation statements)

References 19 publications

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“…Platelet function and 5-hydroxytryptamine (5HT, serotonin) are closely associated with both migraine and tension-type headache (11)(12)(13). In patients with migraine or tension-type headache, low levels of 5HT have been observed in platelets (4,5).…”

Section: Discussionmentioning

confidence: 99%

Platelet Superoxide Dismutase in Migraine and Tension-Type Headache

et al. 1994

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Superoxide dismutase (SOD) is a radical-scavenging enzyme. We determined Cu, Zn-SOD concentrations and activities in platelets from subjects with migraine and tension-type headaches. Thirty migraine without aura (MWoA) patients, 9 migraine with aura (MWA) patients, and 53 tension-type headache patients were selected for study. Thirty healthy volunteers composed the control group. Concentrations of platelet SOD were determined using enzyme-linked immunosorbent assay techniques. The activity of platelet SOD was determined by measuring reductivity of nitroblue tetrazolium. Low concentrations of platelet SOD were found in patients with MWA and MWoA. Platelet SOD activity decreased in MWA patients but not in patients with MWoA or tension-type headaches. These findings suggest vulnerability to oxidative stress in patients with migraine. It is suggested that low platelet SOD levels may play an important role in the etiology of migraine.

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Section: Discussionmentioning

confidence: 99%

Platelet Superoxide Dismutase in Migraine and Tension-Type Headache

et al. 1994

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“…vasoconstrictor agents and improved by vasodilators. 3 Differentiation between patients of common migraine and tension headache may not always be easy; moreover, it is now felt that they may be the polar forms of a continuum of the same clinical spectrum rather than well defined separate entities. Thus while migraine has been termed as a "low serotonin syndrome"16 tension headache on the other end of the clinical spectrum may be called as "high serotonin syndrome".…”

Section: Discussionmentioning

confidence: 99%

Serotonin in tension headache.

Shukla

Shanker

et al. 1987

Journal of Neurology, Neurosurgery & Psychiatry

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SUMMARY Serotonin (5-hydroxytryptamine, 5-HT) is implicated in the pathogenesis of migraine; however, its role in tension headache has not yet been studied. The uptake of 5-HT by platelets in patients of tension headache was significantly higher compared with migraineurs as well as controls. The basal platelet 5-HT levels did not show a significant difference. The study implicates the role of serotonin in tension headache.The involvement of 5-HT in migraine is well established. A decrease in basal platelet 5-HT as well as a reduced uptake of 5-HT by the platelets has been reported.' 4 However, platelet 5-HT uptake in tension headache has not so far been explored. It has been suggested that migraine (classical as well as common), tension-vascular and tension headache are a continuum of the same pathophysiology. The precise margins of these clinical entities are elusive.5 Hence it was considered appropriate to study the role of serotonin in tension headache. This appears to be the first report of platelet serotonin uptake in tension headache. Patients and methodsTwenty patients with tension headache, attending the neurology out-patients department, were included in the study. The mean age was 29 5 with a range of 14 to 45 years and male:female ratio was 1:3. Nineteen patients of migraine were also studied. The mean age was 30 7 years (range 16 to 50 years) and male:female ratio 1:1 7. The diagnosis of migraine was based on the criteria given by the World Federation of Neurology6 whereas tension headache was diagnosed according to the following criteria based on a modification of those suggested by the ad hoc committee of the headache group.7 "Patients with headache lasting for 24 hours, non localised, dull ache described as heaviness or a band being tightened around the head without any nausea or vomiting, precipitated by tension and stressful situations, relieved by sleep or tranquilisers and no relief with ergot alkaloids". Fifteen age and sex matched controls comprising unpaid healthy volunteers taken from hospital staff and patients suffering from neurological disorders not likely to affect 5-HT metabolism (such as myopathy, peripheral neuropathy and motor neuron disease) were also included.Patients suffering from hypertension and ischaemic heart disease were excluded. None of those included in the study was taking drugs (analgesics, antidepressants etc.) and food items (banana, tomato, pineapple, nuts, cheese etc) known to effect 5-HT metabolism, for 7 days prior to collection of blood samples.Blood was collected (9 ml) by venepuncture from the median cubital vein at 9 00 am using a plastic syringe with a 21 gauge needle. It was immediately transferred to plastic tubes, containing I ml of 3-8% sodium citrate, and kept in iced containers.Platelet rich plasma (PRP) was prepared by centrifugation according to the method of Born and Gillson.8 All glass equipment used in the experiments was coated with silicone. Platelet counts in PRP were done in a Neubauer haemocytometer at a dilution of 1 in 20. Basal platelet ...

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“…[4][5][6][7][8][9][10][11] However, these studies have produced results which in many cases are contradictory, partly due to 1) the existence of different types of migraine and of physiological variations, 2) the unpredictable nature of the attack, 3) the possible interference(s) due to treatment(s), and 4) the use of unstandardized methods. For example, various studies report that platelet 5-HT uptake in migrainous platelets is not significantly different from controls, 8,9,12,13 is increased, 14 or is decreased. 15,16 In addition, only V max 15 or both K m and V max 16 modifications have been reported.…”

Section: Introductionmentioning

confidence: 99%

Common Migraine Attack: Platelet Modifications Are Mainly Due to Plasma Factor(s)

Launay

Pradalier

1985

Headache

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SYNOPSIS Various biochemical determinations were performed on plasma and platelets of unmedicated common migrainous patients, either during crisis or in attack‐free intervals. The main change occurring during crisis appears to be a release of dense bodies and a‐granules, with a concomitant decrease of platelet serotonin uptake but without important modifications of the platelet metabolism of bioamines. From the data concerning platelet serotonin uptake, a slight platelet defect cannot be excluded. Nevertheless, the role of unidentified plasma factor(s) appears to be much more important in the genesis of the biochemical changes observed during common migraine attack.

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Serotonin (5‐hydroxytryptamine) Release and Uptake in Platelets From Healthy Persons and Migrainous Patients in Attack‐free Intervals

Cited by 37 publications

References 19 publications

Platelet Superoxide Dismutase in Migraine and Tension-Type Headache

Platelet Superoxide Dismutase in Migraine and Tension-Type Headache

Serotonin in tension headache.

Common Migraine Attack: Platelet Modifications Are Mainly Due to Plasma Factor(s)

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