Serotonin 5-HT2A receptor polymorphisms are associated with irritability and aggression in conduct disorder

Erjavec, Gordana Nedić; Tudor, Lucija; Perković, Matea Nikolac; Podobnik, Josip; Ćurković, Katarina Dodig; Ćurković, Mario; Štrac, Dubravka Švob; Cusek, Melita; Bortolato, Marco; Pivac, Nela

doi:10.1016/j.pnpbp.2022.110542

Cited by 8 publications

(10 citation statements)

References 86 publications

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“…In many physiological and pathological circumstances, activated platelets exhibit inflammatory properties, and can also control endothelial cell permeability [ 49 ]. Secondly, a major source of peripheral 5-hydroxytryptamine (5-HT) linked to aggressive behavior is platelets [ 50 ]. One study found that first-episode schizophrenia patients had considerably greater mid-term platelet levels than did healthy controls [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

The Predictive Value of Monocyte/High-Density Lipoprotein Ratio (MHR) and Positive Symptom Scores for Aggression in Patients with Schizophrenia

Cheng

Zhang

et al. 2023

Medicina

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Background and Objectives: Schizophrenia with aggression often has an inflammatory abnormality. The monocyte/high-density lipoprotein ratio (MHR), neutrophil/high-density lipoprotein ratio (NHR), platelet/high-density lipoprotein ratio (PHR) and lymphocyte/high-density lipoprotein ratio (LHR) have lately been examined as novel markers for the inflammatory response. The objective of this study was to assess the relationship between these new inflammatory biomarkers and aggression in schizophrenia patients. Materials and Methods: We enrolled 214 schizophrenia inpatients in our cross-sectional analysis. They were divided into the aggressive group (n = 94) and the non-aggressive group (n = 120) according to the Modified Overt Aggression Scale (MOAS). The severity of schizophrenia was assessed using the Positive and Negative Syndrome Scale (PANSS). The numbers of platelets (PLT), neutrophils (NEU), lymphocytes (LYM), monocytes (MON) and the high-density lipoprotein (HDL) content from subjects were recorded. The NHR, PHR, MHR and LHR were calculated. We analyzed the differences between those indexes in these two groups, and further searched for the correlation between inflammatory markers and aggression. Results: Patients with aggression had higher positive symptom scores (p = 0.002). The values of PLT, MON, MHR and PHR in the aggressive group were considerably higher (p < 0.05). The NHR (r = 0.289, p < 0.01), LHR (r = 0.213, p < 0.05) and MHR (r = 0.238, p < 0.05) values of aggressive schizophrenia patients were positively correlated with the total weighted scores of the MOAS. A higher MHR (β = 1.529, OR = 4.616, p = 0.026) and positive symptom scores (β = 0.071, OR = 1.047, p = 0.007) were significant predictors of aggression in schizophrenia patients. Conclusions: The MHR and the positive symptom scores may be predictors of aggressive behavior in schizophrenia patients. The MHR, a cheap and simple test, may be useful as a clinical tool for risk stratification, and it may direct doctors’ prevention and treatment plans in the course of ordinary clinical care.

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Section: Discussionmentioning

confidence: 99%

The Predictive Value of Monocyte/High-Density Lipoprotein Ratio (MHR) and Positive Symptom Scores for Aggression in Patients with Schizophrenia

Cheng

Zhang

et al. 2023

Medicina

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“…There is also serotonin receptor gene 2A ( HTR2A ) in the same ROH island. Gene HTR2A was associated with aggression and irritability in humans [ 45 , 46 ], and may be associated with Cornish Rex breed temperament, which has according to the study on cat behavior, low tendency for aggression [ 42 ]. Gene Myosin IA ( MYO1A) is located on ROH island on chromosome B4, and is expressed in the inner ear and is a candidate gene for hearing loss in human [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Selection Signatures Reveal Candidate Genes for the Cornish Rex Breed-Specific Phenotype

Zorc,

Horvat,

Tanšek

et al. 2024

Genes

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Many coat color, behavioral and morphological traits are specific and fixed across cat breeds, with several variants influencing these traits being common among different breeds. In the domestic cat, rexoid mutations have been documented in several breeds. In the Cornish Rex, four bp deletion in the LPAR6 gene has been found to cause a frame shift and a premature stop codon. In addition to the rexoid coat, Cornish Rex cats also have a characteristic head, ear shape and body type. Analysis of the selection signatures in the Cornish Rex genome revealed several regions that are under selective pressure. One of these is located in CFA B4, in the region where the ALX1 gene is located. The ALX1 gene in Burmese cats disrupts the cranial morphogenesis and causes brachycephaly in the heterozygous state. In our study, we confirmed the presence of a deletion in LPAR6 in 20 Cornish Rex and in four F1 hybrids between Cornish Rex and domestic cat. However, we did not confirm the presence of the deletion in ALX1 in Cornish Rex cats. Genome-wide selection signature analysis was performed using ROH islands and integrated haplotype score (iHS) statistics based on publicly available SNP array data of 11 Cornish Rex cats. The selection signatures were detected on chromosomes A1, A3, C2, B1, B4 and D1.

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“…In humans, multiple single nucleotide polymorphisms (SNPs) in the 5-HT2A receptor have been related to antisocial and aggressive behavior in young adults diagnosed with conduct disorder and in two traditional and one industrial Russian populations [ 123 , 124 ]. Furthermore, post-mortem investigations of the OFC in nine individuals with a history of antisocial behavior and substance use disorder (SUD) revealed increased 5-HT2A receptor levels compared to a SUD-only group and healthy controls [ 125 ].…”

Section: The Neurotransmission and Genetics Of Aggressionmentioning

confidence: 99%

Neurobiology of Aggression—Review of Recent Findings and Relationship with Alcohol and Trauma

Fritz

Soravia

Dudeck

et al. 2023

Biology

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Aggression can be conceptualized as any behavior, physical or verbal, that involves attacking another person or animal with the intent of causing harm, pain or injury. Because of its high prevalence worldwide, aggression has remained a central clinical and public safety issue. Aggression can be caused by several risk factors, including biological and psychological, such as genetics and mental health disorders, and socioeconomic such as education, employment, financial status, and neighborhood. Research over the past few decades has also proposed a link between alcohol consumption and aggressive behaviors. Alcohol consumption can escalate aggressive behavior in humans, often leading to domestic violence or serious crimes. Converging lines of evidence have also shown that trauma and posttraumatic stress disorder (PTSD) could have a tremendous impact on behavior associated with both alcohol use problems and violence. However, although the link between trauma, alcohol, and aggression is well documented, the underlying neurobiological mechanisms and their impact on behavior have not been properly discussed. This article provides an overview of recent advances in understanding the translational neurobiological basis of aggression and its intricate links to alcoholism and trauma, focusing on behavior. It does so by shedding light from several perspectives, including in vivo imaging, genes, receptors, and neurotransmitters and their influence on human and animal behavior.

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Serotonin 5-HT2A receptor polymorphisms are associated with irritability and aggression in conduct disorder

Cited by 8 publications

References 86 publications

The Predictive Value of Monocyte/High-Density Lipoprotein Ratio (MHR) and Positive Symptom Scores for Aggression in Patients with Schizophrenia

The Predictive Value of Monocyte/High-Density Lipoprotein Ratio (MHR) and Positive Symptom Scores for Aggression in Patients with Schizophrenia

Selection Signatures Reveal Candidate Genes for the Cornish Rex Breed-Specific Phenotype

Neurobiology of Aggression—Review of Recent Findings and Relationship with Alcohol and Trauma

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