Serotonergic projections from the nodose ganglia to the nucleus tractus solitarius: an immunohistochemical and double labeling study in the rat

Nosjean, Anne; Compoint, C.; Buisseret-Delmas, C.; Orer, Hakan S.; Merahi, Nacera; Puizillout, J.J.; Laguzzi, Raùl

doi:10.1016/0304-3940(90)90422-6

Cited by 71 publications

(25 citation statements)

References 15 publications

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“…5-HT 3 receptors within the NTS are mainly presynaptic and therefore would influence release of neurotransmitter (Huang et al, 2004). In addition to central innervations, the NTS receives input from the peripheral nodose ganglia (Nosjean et al, 1990). Some nodose ganglia neurons innervating the NTS express 5-HT 3A alone, whereas others express both 5-HT 3A and 5-HT 3B subunits (Morales and Wang, 2002).…”

Section: Discussionmentioning

confidence: 99%

Modulation of Human 5-Hydroxytryptamine Type 3AB Receptors by Volatile Anesthetics and n-Alcohols

Stevens¹,

Rüsch²,

Solt³

et al. 2005

J Pharmacol Exp Ther

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Functional 5-hydroxytryptamine type 3 (5-HT 3 ) receptors can be formed by 5-HT 3A subunits alone or in combination with the 5-HT 3B subunit, but only the 5-HT 3A receptor has been previously studied with respect to the modulation by volatile anesthetics and n-alcohols. Using two-electrode voltage-clamp, we show for the first time the modulation of heteromeric human (h)5-HT 3AB receptors, expressed in Xenopus oocytes, by a series of n-alcohols and halogenated volatile anesthetics. At twice their anesthetic concentration, compounds having a molecular volume of less than 110 Å 3 enhanced submaximal 5-HTevoked current. Compounds larger than 110 Å 3 inhibited submaximal 5-HT-evoked current. In experiments examining 5-HT concentration-response relationships, chloroform and butanol caused a slight decrease in the 5-HT EC 50 . Sevoflurane and octanol inhibited 5-HT-evoked current at all 5-HT concentrations tested but had no effect upon the 5-HT EC 50 . Compared with previous data on homomeric h5-HT 3A receptors, the presence of the h5-HT 3B subunit reduces the enhancement of h5-HT 3 receptors by smaller halogenated volatile anesthetics and n-alcohols. In summary, these results suggest that heteromeric h5-HT 3AB receptors are modulated by halogenated volatile anesthetics at clinically relevant concentrations, in addition to n-alcohols, suggesting that these receptors may be another physiological target for these compounds. The modulation is dependent upon the molecular volume of the compound, further supporting the concept of an anesthetic binding pocket of limited volume common on other Cys-loop ligand-gated ion channels. Incorporation of the 5-HT 3B subunit alters either the anesthetic binding site or the allosteric interactions between anesthetic binding and channel opening.

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Section: Discussionmentioning

confidence: 99%

Modulation of Human 5-Hydroxytryptamine Type 3AB Receptors by Volatile Anesthetics and n-Alcohols

Stevens¹,

Rüsch²,

Solt³

et al. 2005

J Pharmacol Exp Ther

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“…(Scha ar et al, 1988). Finally, some vagal a erents terminating in the NTS also contain 5-HT (Nosjean et al, 1990;Sykes et al, 1994). The physiological stimuli which activate these di erent inputs and whether they innervate di erent functional groups of NTS neurones is the basis of a further study.…”

Section: Discussionmentioning

confidence: 99%

In vivo modulation of vagal‐identified dorsal medullary neurones by activation of different 5‐Hydroxytryptamine₂ receptors in rats

Sévoz‐Couche¹,

Spyer²,

Jordan³

2000

British J Pharmacology

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1 In in vivo experiments, DOI (a 5-HT 2 receptor agonist), MK-212 (a 5-HT 2C receptor agonist), and BW-723C86 (a 5-HT 2B receptor agonist) were applied by ionophoresis to neurones in the rat nucleus tractus solitarius (NTS) receiving vagal a erent input. 2 The majority of the putative`monosynaptically' vagal activated cells were inhibited by both MK-212 (4/6) and DOI (2/4), but una ected by . In contrast,`polysynaptically' activated NTS cells were excited by both BW-723C86 (13/19) and DOI (9/10). Inactive`intermediate' cells were inhibited by BW-723C86 (9/12), MK-212 (5/6) and DOI (3/4), whilst active cells of this group were excited by BW-723C86 (7/13) and DOI (5/5). 3 The selective 5-HT 2B receptor antagonist LY-202715 signi®cantly reduced the excitatory actions of BW-723C86 on`intermediate' and`polysynaptic' cells (13/13), but not the inhibitory e ects observed on inactive Group 2 cells (n=5) whereas the selective 5-HT 2C receptor antagonist RS-102221 reversed the inhibitory e ects of MK-212 and DOI on`monosynaptic and`intermediate' neurones. 4 Cardio-pulmonary a erent stimulation inhibited two of four putative`monosynaptically' activated calls and all four inactive intermediate cells. These were also inhibited by DOI and MK-212. In contrast, cardio-pulmonary a erents excited all ®ve active intermediate cells and all six putative`polysynaptically' activated NTS cells, while all were also previously excited by BW-723C86 and/or DOI. 5 In conclusion, these data demonstrate that neurones in the NTS are a ected di erently by 5-HT 2 receptor ligands, in regard of their vagal postsynaptic location, the type of cardio-pulmonary a erent they receive and the di erent 5-HT 2 receptors activated.

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“…The NTS receives serotonergic inputs from serotonergic neurons in the nodose ganglia and from neurons in the medullary raphe nuclei (Thor and Helke, 1987;Nosjean et al, 1990) (Fig. 5), and 5-HT 1A , 5-HT 1B , 5-HT 2 , 5-HT 3 , and 5-HT 4 receptors have been identified within the NTS, including on vagal afferent nerve terminals (Laguzzi, 2003).…”

Section: -Ht and Blood Pressurementioning

confidence: 99%

Serotonin and Blood Pressure Regulation

et al. 2012

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Serotonergic projections from the nodose ganglia to the nucleus tractus solitarius: an immunohistochemical and double labeling study in the rat

Cited by 71 publications

References 15 publications

Modulation of Human 5-Hydroxytryptamine Type 3AB Receptors by Volatile Anesthetics and n-Alcohols

Modulation of Human 5-Hydroxytryptamine Type 3AB Receptors by Volatile Anesthetics and n-Alcohols

In vivo modulation of vagal‐identified dorsal medullary neurones by activation of different 5‐Hydroxytryptamine₂ receptors in rats

Serotonin and Blood Pressure Regulation

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Serotonergic projections from the nodose ganglia to the nucleus tractus solitarius: an immunohistochemical and double labeling study in the rat

Cited by 71 publications

References 15 publications

Modulation of Human 5-Hydroxytryptamine Type 3AB Receptors by Volatile Anesthetics and n-Alcohols

Modulation of Human 5-Hydroxytryptamine Type 3AB Receptors by Volatile Anesthetics and n-Alcohols

In vivo modulation of vagal‐identified dorsal medullary neurones by activation of different 5‐Hydroxytryptamine2 receptors in rats

Serotonin and Blood Pressure Regulation

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Product

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In vivo modulation of vagal‐identified dorsal medullary neurones by activation of different 5‐Hydroxytryptamine₂ receptors in rats