Serotonergic modulation of attack behavior in social isolation mice
Po-Yu Chien,
Chun-Lin Su,
Pei-Hua Liu
et al.
Abstract:Background and Purpose: Intermittent explosive disorder is characterized
by outbursts of rage and violence. While the 5HT
receptor is linked to aggression reduction, its neural circuit mechanism
remains unclear. Here, we explored the impact of the raphe nucleus
projecting to the ventral hippocampus (vHip) on impulsive aggression.
Experimental Approach: We used post-weaning social isolation (SI) mice
as an animal model and employed the chemogenetic technique to
specifically manipulate the activity of neural pat… Show more
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