Serotonergic innervation of the hippocampus and nucleus accumbens septi and the anxiolytic-like action of the 5-ht3 receptor antagonists

Roman, Sabine; Palejko, W; Bidziński, Andrzej; Kostowski, Wojciech; Płaźnik, Adam

doi:10.1016/0028-3908(93)90063-9

Cited by 38 publications

(8 citation statements)

References 24 publications

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“…Thus, the anxiolytic-like effects of intrahippocampal injection of FGIN 1-27 may be due to allopregnanolone synthesis that resulted from the activation of MBR, which in turn potentiated GABA A receptor-mediated neural inhibition. The hippocampus has been implicated in mediating the anxiolytic-like effects of a number of different pharmacological agents, including serotonergic receptor ligands (Kataoka et al 1991;Stefanski et al 1993aStefanski et al , 1993bPrzegalinski et al 1995), benzodiazepines (Campbell et al 1980;Treit and Menard 1998), and corticosteroid receptor antagonists (Smythe et al 1997;Bitran et al 1998b). Recently, we found that injections of pregnanolone in the hippocampus produced dose-dependent anxiolytic-like effects that were mediated by the GABA A receptor complex (Bitran et al 1999).…”

Section: Discussionmentioning

confidence: 96%

Activation of peripheral mitochondrial benzodiazepine receptors in the hippocampus stimulates allopregnanolone synthesis and produces anxiolytic-like effects in the rat

et al. 2000

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Section: Discussionmentioning

confidence: 96%

Activation of peripheral mitochondrial benzodiazepine receptors in the hippocampus stimulates allopregnanolone synthesis and produces anxiolytic-like effects in the rat

et al. 2000

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“…Experiments with muscimol and bicuculline exert a selective mood influence on animal behaviour [34,36,68,69] . The role of GABA A receptors in the limbic system has been well established [34,35,37,38] . It has also been suggested that the origin of emotions is a complex phenomenon, involving the interaction between GABA and many brain structures [34] .…”

Section: Discussionmentioning

confidence: 99%

Effect of Intra-Amygdala Injection of Nicotine and GABA Receptor Agents on Anxiety-Like Behaviour in Rats

Zarrindast¹,

Solati²,

Oryan

et al. 2008

Pharmacology

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There is evidence that both cholinergic and GABAergic systems are involved in the neurobiology of anxiety. In the present study, we investigated the effects and interaction of nicotinic and GABAergic systems in the central amygdala of rats, using the elevated plus maze test of anxiety. Bilateral administration of nicotine (1 and 2 µg/rat; 1 µl/rat; 0.5 µl/rat in each side) into the central amygdala (intra-CeA) induced an anxiogenic-like effect, shown by specific decreases in the percentage of open-arm time (%OAT) and percentage of open arm entries (%OAE). Intra-CeA injection of mecamylamine, a selective nicotine acetylcholine receptor antagonist (20, 30 and 50 ng/rat; 1 µl/rat; 0.5 µl/rat in each side) produced significant anxiolytic-like behaviour. The intra-CeA injection of the GABA_A receptor agonist muscimol (0.25, 0.5 and 0.75 µg/rat; 1 µl/rat; 0.5 µl/rat in each side) decreased %OAT and %OAE, indicating anxiogenic-like behaviour. However, intra-CeA administration of the GABA_A receptor antagonist bicuculline (0.25, 0.5 and 1 µg/rat; 1 µl/rat; 0.5 µl/rat in each side) produced significant anxiolytic-like behaviour. Nicotine in a subeffective dose (0.25 µg/rat) when co-administered with muscimol did not significantly increase the anxiety behaviour. An effective dose of nicotine (2 µg/rat) in combination with bicuculline (0.25, 0.5 and 1 µg/rat) had no interaction on %OAT, %OAE and locomotor activity. It can be concluded that in the central amygdala, the GABAergic system is not involved in the anxiogenic response to nicotine.

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“…The animals were operated under ketamine anesthesia (1 00 mg/kg) and implanted chronically with guide cannulae aimed at the nucleus accumbens septi at the level of commissura anterior, according to the atlas of rat brain, and standard procedures (13,14). The rats were subjected to behavioral testing 7 days later.…”

Section: Methodsmentioning

confidence: 99%

“…It has formerly been shown, that microinjections into the hippocampus and nucleus accumbens of drugs that enhance the inhibitory GABA neurotransmission, as well as of 5-HT, , receptor agonists and 5HT, receptor antagonists, induce anxiolytic-like effects in rats (13,14). All the aforementioned drugs are known to hyperpolarize neurons.…”

Section: Introductionmentioning

confidence: 98%

Effects of intra-accumbens blockade of NMDA receptors in two models of anxiety, in rats

Jessa¹,

Nazar²,

Płaźnik³

1996

Neurosci. Res. Comm.

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In this study the anxiolytic‐like effects of intra‐accumbens administration of (+)‐MK‐801, [(+)‐5‐methyl‐10, 11‐dihydro‐5H‐dibenzo[a,d]cyclohepten‐5, 10‐imine hydrogen maleate; noncompetitive N‐methyl‐D‐aspartate receptor antagonist] and AP‐7, [(+)‐2‐amino‐7‐phosphonoheptanoic acid; competitive NMDA receptor antagonist] in the test of neophobia and the Vogel conflict test, were assessed in rats. Both compounds, although in a limited dose range, disinhibited exploratory activity of non‐habituated rats and increased responding suppressed by punishment, independently from changes in animals motility. The obtained results indicate an anxiolytic‐like effect of local inhibition of NMDA receptor complex within this brain limbic structure, and support the proposal that accumbal glutamate innervation may be involved in processing of emotional input.

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Serotonergic innervation of the hippocampus and nucleus accumbens septi and the anxiolytic-like action of the 5-ht3 receptor antagonists

Cited by 38 publications

References 24 publications

Activation of peripheral mitochondrial benzodiazepine receptors in the hippocampus stimulates allopregnanolone synthesis and produces anxiolytic-like effects in the rat

Activation of peripheral mitochondrial benzodiazepine receptors in the hippocampus stimulates allopregnanolone synthesis and produces anxiolytic-like effects in the rat

Effect of Intra-Amygdala Injection of Nicotine and GABA Receptor Agents on Anxiety-Like Behaviour in Rats

Effects of intra-accumbens blockade of NMDA receptors in two models of anxiety, in rats

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