Serotonergic genes in the development of anxiety/depression-like state and pathology of aggressive behavior in male mice: RNA-seq data

Kudryavtseva, N. N.; Smagin, Dmitry A.; Kovalenko, Irina; Galyamina, Anna G.; Vishnivetskaya, G. B.; Babenko, Vladimir N.; Orlov, Yuriy L.

doi:10.1134/s0026893317020133

Cited by 34 publications

(34 citation statements)

References 53 publications

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“…These pathways mostly down-regulate MAOA, MAOB, EGFR, and CYP2E1, while simultaneously up-regulating CALM1. This matches with the hub genes from PPI network, in which EGFR has been proved to be a significant depression-related gene [28], MAOA and MAOB are crucial target genes of various mental diseases, and MAOA is particularly important in depression and anxiety [25,26]. Moreover, CYP2E1, a member of the cytochrome P450 enzymes family, is referred to as toxicant metabolic enzyme in the liver cell [29].…”

Section: Discussionsupporting

confidence: 75%

“…The results show that HR can down-regulate MAOA, MAOB, and simultaneously up-regulate CALM1 (Figure 11). MAOA and MAOB are crucial target genes of various mental diseases, and MAOA is particularly important in depression and anxiety [25,26]. MAOA is a major degrading enzyme-is encoded by the MAOA gene in humans-in the metabolic pathways of monoamine neurotransmitters such as norepinephrine, dopamine, and serotonin.…”

Section: Pathway Analysis To Explore the Therapeutic Mechanisms Of Hrmentioning

confidence: 99%

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Reveals of New Candidate Active Components in Hemerocallis Radix and Its Anti-Depression Action of Mechanism Based on Network Pharmacology Approach

Lin

Tsai

et al. 2020

IJMS

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The global depression population is showing a significant increase. Hemerocallis fulva L. is a common Traditional Chinese Medicine (TCM). Its flower buds are known to have ability to clear away heat and dampness, detoxify, and relieve depression. Ancient TCM literature shows that its roots have a beneficial effect in calming the spirit and even the temper in order to reduce the feeling of melancholy. Therefore, it is inferred that the root of Hemerocallis fulva L. can be used as a therapeutic medicine for depression. This study aims to uncover the pharmacological mechanism of the antidepressant effect of Hemerocallis Radix (HR) through network pharmacology method. During the analysis, 11 active components were obtained and screened using ADME—absorption, distribution, metabolism, and excretion— method. Furthermore, 267 HR targets and 740 depressive disorder (DD) targets were gathered from various databases. Then protein–protein interaction (PPI) network of HR and DD targets were constructed and cluster analysis was applied to further explore the connection between the targets. In addition, gene ontology (GO) enrichment and pathway analysis was applied to further verify that the biological process related to the target protein is associated with the occurrence of depression disorder. In conclusion, the most important bioactive components—anthraquinone, kaempferol, and vanillic acid—can alleviate depression symptoms by regulating MAOA, MAOB, and ESR1. The proposed network pharmacology strategy provides an integrating method to explore the therapeutic mechanism of multi-component drugs on a systematic level.

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Section: Discussionsupporting

confidence: 75%

Section: Pathway Analysis To Explore the Therapeutic Mechanisms Of Hrmentioning

confidence: 99%

Reveals of New Candidate Active Components in Hemerocallis Radix and Its Anti-Depression Action of Mechanism Based on Network Pharmacology Approach

Lin

Tsai

et al. 2020

IJMS

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“…The midbrain raphe nuclei contain the bodies of serotonergic neurons which are involved in the regulation of many physiological, behavioral, and emotional processes. Repeated experience of aggression and defeats is accompanied by the decrease of serotonergic activity [Kudryavtseva 2006;Avgustinovich et al 2004], which is accompanied by decreased expression of serotonergic genes -Tph2, Maoa, Slc6a4, Htr's Smagin et al 2013;Kudryavtseva et al 2017] in this brain region.…”

Section: Resultsmentioning

confidence: 99%

“…Changes in DNA methylation, histone acetylation and chromatin remodeling often accompany these changes [Hollis et al 2010;Kenworthy et al 2014], as well as decreases in hippocampal neurogenesis rates [Ferragud et al 2010;Lagace et al 2010;Van Bokhoven et al 2011] in defeated mice. We found changes in activity of monoaminergic gene expression in brain regions, activation of cell proliferations in the hippocampus, as well as growth of new neurons under repeated experience of aggression in male mice [Kudryavtseva et al 2004;Filipenko et al 2001;Smagin et al 2013;Smagin et al 2015;Kudryavtseva et al 2017]. Using the transcriptome analysis on RNA-seq data this report is aimed to study the changes of the collagen family gene expression in the 5 brain regions of the male mice with alternative social experience in daily agonistic interactions over a 20-day period.…”

Section: Introductionmentioning

confidence: 99%

Aberrant expression of collagen family genes in the brain regions developing under agonistic interactions in male mice

Smagin

Galyamina

Kovalenko

et al. 2018

Preprint

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SummaryAs previously established, chronic agonistic interactions lead to the development of depression-like state under social defeat stress in the defeated mice and pathology of aggressive behavior in the winning mice. According to the numerous research data, these psychopathological states are accompanied by tremendous molecular and cellular changes in the brain. The paper aimed to study the influence of 20-day period of agonistic interactions on the expression mode of collagen family genes, encoding the proteins, which are basic components of extracellular matrix (ECM), in the different brain regions of mice using the RNA-Seq database. Most of the differentially expressed collagen genes were upregulated in the hypothalamus and striatum of chronically aggressive and defeated mice and in the hippocampus of the defeated mice. In the ventral tegmental area the most genes were downregulated in both experimental groups. It has been assumed that aberrant expression of collagen genes induced by long experience of agonistic interactions can indicate defects of ECM specific for brain regions in mice with alternative social experiences. This study first shows remodeling of molecular base in the ECM under development of experimental psychoneuropathologies.

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“…Animals were placed in pairs in experimental cells separated by a septum which prevents physical contact but has openings that provide sensory contact. Every day the partition was removed for 10 minutes which overwhelmingly led to agonistic collisions (confrontations) [2]. Groups of animals with alternative types of behavior were formed: aggressive type -in case of repeated victories experience (winner, aggressor) and submissive type -in case of defeats (victim).…”

Section: A T E R I a L A N D M E T H O D Smentioning

confidence: 99%

Influence of Semax on the Intensity of Redox Reactions in Immunocompetent Organs in the Conditions of "Social" Stress

Ясенявская¹,

Самотруева²,

Murtalieva³

et al. 2019

AREM

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a B s t r a C t -The experiment investigated the effect of Semax (Met-Glu-His-Phe-Pro-Gly-Pro) on the intensity of redox reactions in immunocompetent organs (thymus and spleen) on the model of "social" stress. The intensity of redox processes was assessed by determining the intensity of lipid peroxidation (LPO) in immunocompetent organs (thymus and spleen) and catalase activity. "Social" stress, formed in the experiment, is accompanied by an increase in the peroxidation processes in immunocompetent organs, which contributes to the development of stress-induced functional disorders of the immune system. Under the influence of "social" stress, the activity of the investigated antioxidant enzyme in the thymus and spleen increased in comparison with the corresponding indicators in intact rats. Against the background of Semax administration under "social" stress, its pronounced corrective effect on lipid peroxidation rates is observed, as evidenced by a decrease in spleen and thymus tissue homogenates of male rats in the baseline level of TBАreactive products, speed of spontaneous and ascorbatedependent lipid peroxidation, and catalase activity.

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Serotonergic genes in the development of anxiety/depression-like state and pathology of aggressive behavior in male mice: RNA-seq data

Cited by 34 publications

References 53 publications

Reveals of New Candidate Active Components in Hemerocallis Radix and Its Anti-Depression Action of Mechanism Based on Network Pharmacology Approach

Reveals of New Candidate Active Components in Hemerocallis Radix and Its Anti-Depression Action of Mechanism Based on Network Pharmacology Approach

Aberrant expression of collagen family genes in the brain regions developing under agonistic interactions in male mice

Influence of Semax on the Intensity of Redox Reactions in Immunocompetent Organs in the Conditions of "Social" Stress

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