Serotonergic genes and personality traits in the Korean population

Ham, Byung‐Joo; Kim, Yong Ho; Choi, Myung Jin; Hyun, Jae Chun; Choi, Yun Kyeung; Lee, Min Soo

doi:10.1016/s0304-3940(03)00753-5

Cited by 43 publications

(32 citation statements)

References 19 publications

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“…To date, there has only been 1 study of the Korean population which investigated the relationships between 5-HTT polymorphism and personality traits [17] . In contrast to our results, in this study, no associations were found between 5-HTTLPR and any of the subscales of the TCI.…”

Section: Discussionmentioning

confidence: 99%

Serotonin Transporter Gene Polymorphism and Personality Traits in a Korean Population

Kim

Kim²,

Choi³

et al. 2005

Neuropsychobiology

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Recently, there has been growing enthusiasm for exploring biological approaches to personality, especially in the area of genetic research into the identification of those genes responsible for particular personality traits. The aim of this study was to investigate the association between the serotonin transporter-linked promoter region (5-HTTLPR) polymorphism and personality traits. We recruited 211 unrelated, normal subjects. The Korean version of the Temperament and Character Inventory (TCI) was used to assess certain personality traits. From blood samples taken from the subjects, DNA was isolated using standard techniques and the 5-HTTLPR polymorphism was genotyped by means of polymerase chain reaction and electrophoresis. We classified the subject into the s/s, s/l, and l/l groups according to their genotype. The differences in the temperament factors of the TCI between group S (s/s genotype) and group L (s/l + l/l genotype) were assessed, after the inclusion of gender and age as covariates in the analysis of variance. After controlling for gender and age, there were no associations between the harm avoidance, novelty seeking, and reward dependence scores and the genotypes. However, the persistence score of group S was significantly higher than that of group L. Our results suggest that the 5-HTTLPR polymorphism may be associated with the persistence score of the TCI in a normal Korean population.

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Section: Discussionmentioning

confidence: 99%

Serotonin Transporter Gene Polymorphism and Personality Traits in a Korean Population

Kim

Kim²,

Choi³

et al. 2005

Neuropsychobiology

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“…In so me stu di es, no velty se e king was shown to be re la ted with DRD4 poly morpTurkiye Klinikleri J Med Sci 2010;30 (5) [19][20][21] Se veral stu di es ob ser ved as so ci a ti ons bet we en 5-HT2A and no velty se e king. 22 In con trast, some stu di es reve a led that 5-HT2A was ne ga ti vely re la ted with cons ci en ti o us ness 23 and po si ti vely cor re la ted with ne u ro ti cism (emo ti o nal sta bi lity). [24][25][26] In this study, si mi lar to open ness to ex pe ri en ce, emo ti o nal sta bility was fo und to be as so ci a ted with both 5-HT2A poly morp hism and RSP.…”

Section: Discussionmentioning

confidence: 99%

Personality Traits and DRD4, DAT1, 5-HT2A Gene Polymorphisms in Risky and Non Risky Sports Participation

Çam¹,

Çolakoğlu²,

Tok³

et al. 2010

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob b j je ec c t ti i v ve e: : Re la ti ons hips amongst Big Fi ve per so na lity tra its and DRD4, DAT1 and 5-HT2A ge ne poly morp hisms we re in ves ti ga ted in 193 col le ge stu dents par ti ci pa ting in risky and non-risky sports. M Ma a t te e r ri i a al l a an nd d M Me et t h ho od ds s: : Per so na lity tra its we re as ses sed by Fi ve Fac tor Per so na lity In ven tory (FFPI) and ge ne poly morp hisms we re analy zed by poly me ra se cha in reac ti on. R Re e s su ul lt ts s: : In or der to exa mi ne whet her sig ni fant Big Fi ve per so na lity tra it dif fe ren ces exis ted bet we en DAT1 ge ne po li morp hisms, in de pen dent samp le t-test was used. Re sults sho wed that only Ag re e ab le ness di men si on re ve a led sig ni fi cant dif fe ren ce in di ca ting that in di vi du als with non-10/10 ge noty pe had hig her ag re e ab le ness sco res when com pa red to in di vi du als with 10/10 ge noty pe. ANO VA re sults sho wed that Big Fi ve per so na lity di men si ons sco res dif fe red sig ni fi cantly amongst 5-HT2A ge noty pes. In di vi du als with CC ge noty pe had lo wer emo ti o nal sta bi lity sco res when com pa red to in di vi du als with TC ge noty pe, and CC ge noty pe in di vi du als had gre a ter open ness to ex pe ri en ce sco res when com pa red to TT ge noty pe in di vi du als. Openness to ex pe ri en ce sco res we re al so sig ni fi cantly dif fe rent among DRD4 ge noty pes. In di vi du als with ll ge noty pe had gre a ter open ness to ex pe ri en ce sco res when com pa red to in di vi du als with ss ge noty pe. No 5-HT2A and risky sport par ti ci pa ti on (RSP) in te rac ti on ef fect was fo und on emo ti o nal chan ge sco re. C Co on nc c l lu u s si i o on n: : DAT1 was not as so ci a ted with RSP. It was conc lu ded that DRD4 and 5-HT2A we re not di rectly as so ci a ted with RSP but may be used as in di rect pre dictors of it.K Ke ey y W Wo or rd ds s: : Poly morp hism, ge ne tic; per so na lity Ö ÖZ ZE ET T A Am ma aç ç: : Bu araş tır ma da risk li ve risk siz spor la ra ka tı lım da ki şi lik özel lik le ri ile DRD4, DAT1, 5HT2A gen po li mor fizm le ri ara sın da ki iliş ki, risk li ve risk siz spor la ra ka tı lan 193 üni ver si te öğ renci sin de araş tı rıl mış tır. G Ge e r re eç ç v ve e Y Yö ön n t te em m l le er r: : Ki şi lik özel lik le ri Beş Fak tör lü Ki şi lik En van te ri ile öl -çül müş, gen po li mor fizm le ri po li me raz zin cir rek si yo nu ile tes pit edil miş tir. B Bu ul l g gu u l la ar r: : Beş ana ki şi lik özel li ği nin DAT1 gen po li mor fizm le ri ara sın da fark lı lık gös te rip gös ter me di ği ni in ce le mek için bağım sız iki ör nek t tes ti kul la nıl mış ve non-10/10 ge no ti pe sa hip bi rey le rin da ha yük sek "yu mu şak -baş lı lık" sko ru el de et tik le ri bu lun muş tur. 5-HT2A gen po li mor fizm le ri ara sın da ki şi lik fark lı lık la rı nı in ce le mek için ya pı lan var yans ana li zi so nu cun da ise CC ge no ti pi ne sa hip bi rey le rin, TC ge no ti pi ne sa hip bi rey ler den da ha dü şü...

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“…In addition, there is increase evidence of the association between the 5-HTT and DRD2/DRD4 polymorphisms with character dimensions which, according to Cloninger's Theory, are acquired during the development through socio-cultural learning and not as genetically determined as the temperament dimensions (Cloninger et al 1994). Studies from different cultural populations reported that healthy subjects carriers of the short allele within the 5-HTT showed lower scores in all the Cloninger's character dimensions, including Self-Transcendence (Ham et al 2004), Self-Directedness (Gonda et al 2009;Saiz et al 2010;Calati et al 2014) and Cooperativeness (Pełka-Wysiecka et al 2012). Similarly, for the DRD2 polymorphism, Tsuchimine et al (2012) found that the less frequent allele was associated with significant lower scores in the Self-Directedness scale (Table 1).…”

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confidence: 91%

The association between the serotonin and dopamine neurotransmitters and personality traits

Delvecchio

Altamura

Brambilla

2016

Epidemiol Psychiatr Sci

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This Section of Epidemiology and Psychiatric Sciences appears in each issue of the Journal to stress the relevance of epidemiology for behavioral neurosciences, reporting the results of studies that explore the use of an epidemiological approach to provide a better understanding of the neural basis of major psychiatric disorders and, in turn, the utilisation of the behavioural neurosciences for promoting innovative epidemiological research.The ultimate aim is to help the translation of most relevant research findings into every-day clinical practice. These contributions are written in house by the journal's editorial team or commissioned by the Section Editor (no more than 1000 words, short unstructured abstract, 4 key-words, one Table or Figure and up to ten references). Paolo Brambilla, Section EditorThe association between the serotonin and dopamine neurotransmitters and personality traits Evidence from previous studies has reported that complex traits, including psychiatric disorders, are moderately to highly heritable. Moreover, it has also been shown that specific personality traits may increase the risk to develop mental illnesses. Therefore the focus of the research shifted towards the identification of the biological mechanisms underpinning these traits by exploring the effects of a constellation of genetic polymorphisms in healthy subjects. Indeed, studying the effect of genetic variants in normal personality provides a unique means for identifying candidate genes which may increase the risk for psychiatric disorders. In this review, we discuss the impact of two of the most frequently studied genetic polymorphisms on personality in healthy subjects, the 5-HTT polymorphism of the serotonin transporter and the DRD2/DRD4 polymorphisms of the D2/D4 dopamine's receptors. The main aims are: (a) to highlight that the study of candidate genes provides a fruitful ground for the identification of the biological underpinnings of personality without, though, reaching a general consensus about the strength of this relationship; and (b) to outline that the research in personality genetics should be expanded to provide a clearer picture of the heritability of personality traits.

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Serotonergic genes and personality traits in the Korean population

Cited by 43 publications

References 19 publications

Serotonin Transporter Gene Polymorphism and Personality Traits in a Korean Population

Serotonin Transporter Gene Polymorphism and Personality Traits in a Korean Population

Personality Traits and DRD4, DAT1, 5-HT2A Gene Polymorphisms in Risky and Non Risky Sports Participation

The association between the serotonin and dopamine neurotransmitters and personality traits

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