Serotonergic functioning in depressed abused children: clinical and familial correlates

Kaufman, Joan; Birmaher, Boris; Perel, James M.; Dahl, Ronald E.; Stull, Stacy; Brent, David; Trubnick, Laura; Al-Shabbout, Mayadah; Ryan, Neal D.

doi:10.1016/s0006-3223(98)00203-0

Cited by 64 publications

(33 citation statements)

References 47 publications

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“…Indicative of serotonergic dysfunction, abused children with depression were shown to exhibit increased prolactin but normal cortisol responses to the injection of L-5-hydroxytryptophan, a precursor of 5-HT, compared with nonabused depressed children and control subjects (Kaufman et al 1998). Likewise, increased prolactin responses to fenfluramine were observed in boys with adverse rearing environment (Pine et al 1997).…”

Section: Studies In Childrenmentioning

confidence: 99%

“…It may be argued that peripheral measures of pituitary-adrenal activity may not reflect central CRF activity at extrahypothalamic sites and, moreover, that peripheral changes may only develop over time with chronic or repeated depression (Martin et al 2000). Differential pathophysiology of depression at different developmental stages is further reflected by differences in responses to pharmacologic treatments in patients of different ages (Martin et al 2000); however, there is evidence that CRH and serotonergic alterations are present in depressed children with histories of maltreatment, but not in depressed nonabused children (Kaufman et al 1997(Kaufman et al , 1998; see next section), suggesting that preclinical studies on early life stress represent a heuristic specifically for understanding depression associated with early trauma. This subtype of depression may also more frequently occur in comorbidity with anxiety disorders.…”

Section: Comparison Of Preclinical Findings On the Neurobiological Comentioning

confidence: 99%

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The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies

Heim

Nemeroff

2001

Biological Psychiatry

2,393

1,506

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Section: Studies In Childrenmentioning

confidence: 99%

Section: Comparison Of Preclinical Findings On the Neurobiological Comentioning

confidence: 99%

The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies

Heim

Nemeroff

2001

Biological Psychiatry

2,393

1,506

View full text Add to dashboard Cite

“…Evidence suggests that maternal sensitivity and other dimensions of parenting behavior are significant components of infant attachment security (De Wolff & van IJzendoorn, 1997). 7 Although lower levels of serotonergic activity are associated with aggressive behavior in adults, in preadolescent samples, the relation is often the reverse with especially high serotonin levels correlated with aggression, depression, and other adverse outcomes (Kaufman et al, 1998). and less grooming. 8 Monkeys with the short 5-HTT allele who were raised by peers showed lower concentrations of the primary central serotonin metabolite (5-HIAA) than was true for monkeys with the long allele.…”

Section: Serotonergic Functioningmentioning

confidence: 99%

Risky families: Family social environments and the mental and physical health of offspring.

Repetti¹,

Taylor²,

Seeman³

2002

Psychological Bulletin

1,196

1,726

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Risky families are characterized by conflict and aggression and by relationships that are cold, unsupportive, and neglectful. These family characteristics create vulnerabilities and/or interact with genetically based vulnerabilities in offspring that produce disruptions in psychosocial functioning (specifically emotion processing and social competence), disruptions in stress-responsive biological regulatory systems, including sympathetic-adrenomedullary and hypothalamic-pituitary-adrenocortical functioning, and poor health behaviors, especially substance abuse. This integrated biobehavioral profile leads to consequent accumulating risk for mental health disorders, major chronic diseases, and early mortality. We conclude that childhood family environments represent vital links for understanding mental and physical health across the life span.

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“…Neuroimaging studies in children exposed to maltreatment also show changes in corpus collusum and hippocampus volume that may account for some of the cognitive findings associated with a history of maltreatment (61). Abuse and adverse rearing environments result in a decrease in central serotonergic function, a biological system that has been linked to impulsive aggression and suicidal behavior (120)(121)(122)(123)(124).…”

Section: Childhood Experience Of Abusementioning

confidence: 99%

“…This finding has been replicated several times (71;128-130). Kaufman et al found that the risk for depression was greatest in abused children who also had a family history of depression (124).…”

Section: Interactions Between Genes and Environmentmentioning

confidence: 99%

Familial Transmission of Suicidal Behavior

Brent¹,

Melhem²

2008

Psychiatric Clinics of North America

257

199

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Suicide and suicidal behavior is highly familial, and appears to be familially transmitted independently from the familial transmission of psychiatric disorder per se (1). Adoption, twin, and family studies support the view that the etiology of the familial transmission of suicidal behavior is at least in part genetic, and may be mediated by the transmission of intermediate phenotypes, such as impulsive aggression. In addition, there may be environmental causes for familial transmission, including imitation, and the intergenerational transmission of family adversity. In this review, we cover the evidence supporting the familial transmission of suicidal behavior, possible genetic and environmental explanations for this phenomenom, describe putative intermediate phenotypes, and discuss the contributory roles of early child-rearing and concurrent familial environmental stressors to suicidal risk. A better understanding of the mechanisms for the familial transmission of suicidal behavior can help to shed light on etiology, identify individuals at high risk for the development of incident suicidal behavior, and frame targets for intervention and prevention.Adoption studies (see Table 1) Three adoption studies have been conducted, all using the same Danish adoption registry. Kety et al., in a study designed to examine the genetics of schizophrenia and mood disorders, found a non-significant trend towards higher concordance for suicide in biological, compared to adoptive relatives of adoptees who committed suicide (2). Subsequently, a second study compared the rates of suicide among the biological and adoptive relatives of adoptees who committed suicide vs. biological and adoptive relatives of a matched living adoptee control group in Denmark (3). This study found a six-fold higher rate of suicide in the biological relatives of the suicide vs. those of the control adoptees, and an absence of suicide among the adopted relatives of the suicide vs. control adoptees supporting a genetic rather than environmental etiology (see Table 1). The rate of suicide was higher in the biologic relatives of suicide adoptees regardless of whether the adoptees were psychiatric patients or not. However, it was not possible to determine if the genetic liability to suicide was attributable to the transmission of major psychiatric disorders or to a suicide diathesis per se.In a third adoption study using this registry, a comparison of biological and adoptive relatives of adult adoptees with mood disorder and matched unaffected adoptees were examined (4), revealed a 15-fold increase in suicide among the biological relatives of the mood-disordered adoptees vs. those of the unaffected adoptees (4). This finding supports the role of mood disorder in the genetics of suicide. However, the greatest increased risk for suicidal behavior was found in the relatives of those probands with "affect reaction," a diagnosis akin to Corresponding Author: Dr. David Brent, BrentDA@upmc.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript th...

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Serotonergic functioning in depressed abused children: clinical and familial correlates

Cited by 64 publications

References 47 publications

The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies

The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies

Risky families: Family social environments and the mental and physical health of offspring.

Familial Transmission of Suicidal Behavior

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