Serotonergic Deficits and Impaired Passive-Avoidance Learning in Rats by MDEA

Barrionuevo, M; Aguirre, Norberto; Rı́o, Joaquı́n Del; Lasheras, B.

doi:10.1016/s0091-3057(99)00170-7

Cited by 32 publications

(27 citation statements)

References 34 publications

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“…As mentioned above, MDMA treatment can impair learning and memory (15). It has been reported that MDMA treatment leads to reduction in preference for the target quadrant in the Morris water maze (16) and impairment of retention in passive avoidance tasks (17). Moreover, MDMA decreases 5-HT levels in the amygdala, hippocampus, and striatum that involve learning and memory (12,18) and are susceptible to 5-HT neurotoxicity following MDMA treatment (19).…”

Section: Discussionmentioning

confidence: 98%

Acute and Chronic Effects of 3-4, Methylenedioxymethamphetamine on Pyramidal Cells of Hippocampus

Shariati¹,

Mirzaei²,

Asl³

et al. 2014

Avicenna J Neuro Psych Physio

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Background: Ecstasy or 3-4, methylenedioxymethamphetamine (MDMA), as an amphetamine derivate, could lead to learning and memory impairment. Objectives: As the hippocampus is responsible for learning and memory, herein we evaluated acute and chronic effects of MDMA on the structure of the hippocampus. Materials and Methods: Male Wistar rats (200-250 g) received single or multiple injections of MDMA (10 mg/kg, IP). At the end of the study, rats were killed and their brains were removed. Hippocampus sections were prepared to study the structure of hippocampus CA1. Data was analyzed using SPSS 16 software and one-way analysis of variance test. Results: Our findings showed that cell density decreased in MDMA-treated groups in comparison to the intact group. Administration of multiple doses of MDMA significantly decreased the cell number when compared with intact (P < 0.001) and acute (P < 0.01) groups. Conclusions: These data suggest that MDMA treatment caused cell death in CA1, which was more extensive in the chronic treatment group.

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Section: Discussionmentioning

confidence: 98%

Acute and Chronic Effects of 3-4, Methylenedioxymethamphetamine on Pyramidal Cells of Hippocampus

Shariati¹,

Mirzaei²,

Asl³

et al. 2014

Avicenna J Neuro Psych Physio

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“…MDMA produces acute and long-term serotonergic neurotoxicity in rodents, primates, and, possibly, in humans, with the severity of toxicity dependent on the dose and frequency of administration (Green et al, 2003). Such neurotoxicity is demonstrated by a decrease in tryptophan hydroxylase activity (Stone et al, 1988), a reduction in serotonin content, a dose-dependent persistent decrease in the number of 5-HT transporter sites and 5-HT receptors in several regions of the brain (Aguirre et al, 1995;Ricaurte et al, 2000), and an impairment of central 5-HT function (Barrionuevo et al, 2000). …”

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confidence: 99%

Neurotoxic Thioether Adducts of 3,4-Methylenedioxymethamphetamine Identified in Human Urine After Ecstasy Ingestion

et al. 2009

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3,4-Methylenedioxymethamphetamine (MDMA, Ecstasy) is a psychostimulant widely abused among young people. MDMA exhibits distinct pharmacological properties, collectively described as entactogenic, which differentiate it from classic amphetamines (Nichols, 1986). MDMA produces acute and long-term serotonergic neurotoxicity in rodents, primates, and, possibly, in humans, with the severity of toxicity dependent on the dose and frequency of administration (Green et al., 2003). Such neurotoxicity is demonstrated by a decrease in tryptophan hydroxylase activity (Stone et al., 1988), a reduction in serotonin content, a dose-dependent persistent decrease in the number of 5-HT transporter sites and 5-HT receptors in several regions of the brain (Aguirre et al., 1995;Ricaurte et al., 2000), and an impairment of central 5-HT function (Barrionuevo et al., 2000).

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“…Braida et al (2002) found that acute administration of up to 3 mg/kg MDMA initially had no effect on the number of errors in a standard eight-arm radial maze task, but when a 2-h delay was imposed, MDMA dose-dependently impaired performance. Similarly, administration of MDMA (10 mg/kg) prior to acquisition of a passive avoidance task impaired memory assessed 24 h later (Barrionuevo et al, 2000). The studies by Braida et al, and Barrionuevo et al, employed much longer delays than those reported here.…”

Section: Discussionmentioning

confidence: 46%

“…In laboratory animals, short-term memory, color discrimination, and position discrimination were not affected by acute MDMA (Frederick and Paule, 1997;Ricaurte et al, 1993), while time estimation, motivation, and learning were impaired. Braida et al (2002) found no effect of MDMA on acute short-term memory in rats, but subacute memory was affected (see also Barrionuevo et al, 2000). In human studies, MDMA users have demonstrated verbal memory impairments both while on-drug (Parrott and Lasky, 1998; and after a history of ecstasy use, while other cognitive functions appeared normal (Bolla et al, 1998;Reneman et al, 2000).…”

Section: Introductionmentioning

confidence: 92%

Co-administration of THC and MDMA (‘Ecstasy’) Synergistically Disrupts Memory in Rats

Young

McGregor

Mallet

2005

Neuropsychopharmacol

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3,4-Methylenedioxymethamphetamine (MDMA, 'Ecstasy') and cannabis are two of the most commonly used illicit drugs in the western world, and are often used in combination. Very little research has examined their effect on cognitive function or behavior when combined. The present study used a double Y-maze task to examine the acute effect of MDMA and D 9 -tetrahydrocannabinol (THC, the principal psychoactive ingredient of cannabis) on mnemonic function in rats, at a range of doses representative of common human use. Experiment 1 (low doses) examined the effect of 0.25 mg/kg THC and 1.25 mg/kg MDMA alone and together. At these doses MDMA or THC given alone had no effect on working memory, but the co-administered drugs significantly disrupted working memory. Experiment 2 (medium doses) examined the effect of 0.5 mg/kg THC and 2.5 mg/kg MDMA given alone or together. At these doses THC, but not MDMA, impaired working memory. Although MDMA alone had no effect, it exacerbated the impairment due to THC when the drugs were co-administered. Experiment 3 (high doses) examined the effects of 1 mg/kg THC and 5 mg/kg MDMA alone and together. Both drugs significantly impaired memory when given alone, although the impairment due to MDMA was less than that caused by THC. When co-administered at these doses, the drugs caused a major disruption of behavior and this precluded ascribing a mnemonic cause to poor performance on the double Y-maze task. Taken together, these experiments demonstrate a synergistic disruption of working memory by acute co-administration of THC and MDMA.

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Serotonergic Deficits and Impaired Passive-Avoidance Learning in Rats by MDEA

Cited by 32 publications

References 34 publications

Acute and Chronic Effects of 3-4, Methylenedioxymethamphetamine on Pyramidal Cells of Hippocampus

Acute and Chronic Effects of 3-4, Methylenedioxymethamphetamine on Pyramidal Cells of Hippocampus

Neurotoxic Thioether Adducts of 3,4-Methylenedioxymethamphetamine Identified in Human Urine After Ecstasy Ingestion

Co-administration of THC and MDMA (‘Ecstasy’) Synergistically Disrupts Memory in Rats

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