Serotonergic control of developmental plasticity

Kirkwood, Alfredo

doi:10.1073/pnas.070044697

Cited by 34 publications

(22 citation statements)

References 17 publications

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“…In the visual cortex, nonglutamatergic receptors have been primarily regarded as modulators that promote or facilitate the induction of LTP and LTD with suboptimal stimulation (Brocher et al, 1992;Kirkwood et al, 1999;Kirkwood, 2000;Kojic et al, 2000). Contrary to this notion, we found that the activation of receptors coupled to PLC is essential for the induction of LTD in the layer IV3 III pathway of the visual cortex.…”

Section: Discussioncontrasting

confidence: 53%

“…In contrast, in vivo studies indicate that developmental plasticity in the sensory cortex not only requires NMDARs (Kleinschmidt et al, 1987;Fox et al, 1996;Roberts et al, 1998;Daw et al, 1999;Iwasato et al, 2000) but also depends on the integrity of cholinergic, noradrenergic, and serotonergic innervation (Kasamatsu and Pettigrew, 1976;Bear and Singer, 1986;Gu and Singer, 1995;Siciliano et al, 1997;Gu, 2002). However, in vitro studies have led to the suggestion that these extra-retinal inputs act as neuromodulators that, like changes in the inhibitory tone (Steele and Mauk, 1999), facilitate or promote NMDAR-dependent plasticity, but without being essential for the induction mechanism (Brocher et al, 1992;Kirkwood et al, 1999;Kirkwood, 2000;Kojic et al, 2000).…”

Section: Introductionmentioning

confidence: 91%

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Multiple Receptors Coupled to Phospholipase C Gate Long-Term Depression in Visual Cortex

Choi¹,

Chang²,

Jiang³

et al. 2005

J. Neurosci.

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Long-term depression (LTD) in sensory cortices depends on the activation of NMDA receptors. Here, we report that in visual cortical slices, the induction of LTD (but not long-term potentiation) also requires the activation of receptors coupled to the phospholipase C (PLC) pathway. Using immunolesions in combination with agonists and antagonists, we selectively manipulated the activation of ␣1 adrenergic, M1 muscarinic, and mGluR5 glutamatergic receptors. Inactivation of these PLC-coupled receptors prevents the induction of LTD, but only when the three receptors were inactivated together. LTD is fully restored by activating any one of them or by supplying intracellular D-myo-inositol-1,4,5-triphosphate (IP 3 ). LTD was also impaired by intracellular application of PLC or IP 3 receptor blockers, and it was absent in mice lacking PLC␤1, the predominant PLC isoform in the forebrain. We propose that visual cortical LTD requires a minimum of PLC activity that can be supplied independently by at least three neurotransmitter systems. This essential requirement places PLC-linked receptors in a unique position to control the induction of LTD and provides a mechanism for gating visual cortical plasticity via extra-retinal inputs in the intact organism.

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Section: Discussioncontrasting

confidence: 53%

Section: Introductionmentioning

confidence: 91%

Multiple Receptors Coupled to Phospholipase C Gate Long-Term Depression in Visual Cortex

Choi¹,

Chang²,

Jiang³

et al. 2005

J. Neurosci.

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“…In contrast to the present study, 5-HT facilitated the induction of long-term synaptic plasticity in cats [24,44] and in adult rats [45]. Since 5-HT receptor distribution is heterogeneous in various species and brain regions [32], 5-HT could affect various cellular functions differently in different conditions.…”

Section: Discussioncontrasting

confidence: 51%

Effects of Serotonin on the Induction of Long-term Depression in the Rat Visual Cortex

Jang

Cho

Park

et al. 2010

Korean J Physiol Pharmacol

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Long-term potentiation (LTP) and long-term depression (LTD) have both been studied as mechanisms of ocular dominance plasticity in the rat visual cortex. In a previous study, we suggested that a developmental increase in serotonin [5-hydroxytryptamine (5-HT)] might be involved in the decline of LTP, since 5-HT inhibited its induction. In the present study, to further understand the role of 5-HT in a developmental decrease in plasticity, we investigated the effect of 5-HT on the induction of LTD in the pathway from layer 4 to layer 2/3. LTD was inhibited by 5-HT (10 μM) in 5-week-old rats. The inhibitory effect was mediated by activation of 5-HT2 receptors. Since 5-HT also regulates the development of visual cortical circuits, we also investigated the role of 5-HT on the development of inhibition. The development of inhibition was retarded by chronic (2 weeks) depletion of endogenous 5-HT in 5-week-old rats, in which LTD was reinstated. These results suggest that 5-HT regulates the induction of LTD directly via activation of 5-HT2 receptors and indirectly by regulating cortical development. Thus, the present study provides significant insight into the roles of 5-HT on the development of visual cortical circuits and on the age-dependent decline of long-term synaptic plasticity.

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“…There is ample evidence that noradrenaline, acetylcholine and serotonin modulate two different forms of activity-dependent synaptic modifications: long-term potentiation (LTP) and long-term depression (LTD) (Kirkwood 2000). In the visual system, LTP and LTD can be induced by different patterns of electrical stimulation.…”

Section: Long-distance Projection Systems Regulate Plasticity In the mentioning

confidence: 99%

Insights into Visual Cortex Plasticity: Interaction Between Genes and Sensory Experience

Maya‐Vetencourt¹,

Caleo²

2012

Visual Cortex - Current Status and Perspectives

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Serotonergic control of developmental plasticity

Cited by 34 publications

References 17 publications

Multiple Receptors Coupled to Phospholipase C Gate Long-Term Depression in Visual Cortex

Multiple Receptors Coupled to Phospholipase C Gate Long-Term Depression in Visual Cortex

Effects of Serotonin on the Induction of Long-term Depression in the Rat Visual Cortex

Insights into Visual Cortex Plasticity: Interaction Between Genes and Sensory Experience

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