Serotonergic connections to the ventral oral pontine reticular nucleus: Implication in paradoxical sleep modulation

Rodrigo-Angulo, Margarita L.; Rodríguez‐Veiga, Elisia; Reinoso‐Suárez, Fernando

doi:10.1002/(sici)1096-9861(20000228)418:1<93::aid-cne7>3.0.co;2-1

Cited by 25 publications

(17 citation statements)

References 44 publications

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“…Furthermore, dysregulated 5-HTergic neurotransmission contributes to diverse neuropsychiatric illnesses, including major depression, bipolar disorder, suicide, sleep disorders, conduct disorders, Tourette’s syndrome, and psychosis (Arango et al, 2002; Asberg et al, 1976; de Boer and Koolhaas, 2005; Lopez-Figueroa et al, 2004; Parsey et al, 2006; Rodrigo-Angulo et al, 2000; Thase, 1999). Despite such widespread functional roles, 5-HTergic neurons number only in the tens of thousands in the mammalian brain, yet these cells are highly complex, sending collateralized projections to multiple targets (Jacobs and Azmitia, 1992; Steinbusch, 1984).…”

Section: Introductionmentioning

confidence: 99%

High novelty-seeking predicts aggression and gene expression differences within defined serotonergic cell groups

et al. 2011

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Aggression frequently coincides with specific dimensions of emotionality, such as impulsivity, risk-taking, and drug abuse. Serotonergic (5-HTergic) neurotransmission contributes to the regulation of numerous neurobiological functions, and is thought to play a key role in modulating aggressive responses. The current study uses selectively-bred High (bHR) and Low (bLR) Responder rats that exhibit differences in emotionality and behavioral control, with bHRs exhibiting heightened novelty-induced exploration, impulsivity, and increased sensitivity to drugs of abuse, and with bLRs characterized by exaggerated depressive- and anxiety-like behaviors. Based on this behavioral profile we hypothesized that bHR rats exhibit increased aggression along with changes in testosterone and corticosterone secretion characteristic of aggression, and that these changes are accompanied by alterations in the expression of key genes that regulate 5-HTergic neurotransmission (Tph2 and Sert) as well as in the activation of 5-HTergic cell groups following aggressive encounter. Our data demonstrate that when compared to bLR rats, bHRs express increased baseline Tph2 and Sert in select brainstem nuclei, and when tested on the resident-intruder test they exhibited: 1) increased aggressive behavior; 2) potentiated corticosterone and testosterone secretion; and 3) diminished intrusion-induced c-fos expression in select 5-HTergic brainstem cell groups. The most prominent gene expression differences occurred in the B9 cell group, pontomesencephalic reticular formation, median raphe, and the gigantocellular nucleus pars α. These data are consistent with the notion that altered 5-HT neurotransmission contributes to bHRs’ heightened aggression. Furthermore, they indicate that a specific subset of brainstem 5-HTergic cell groups contributes to the regulation of intrusion-elicited behavioral responses.

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Section: Introductionmentioning

confidence: 99%

High novelty-seeking predicts aggression and gene expression differences within defined serotonergic cell groups

et al. 2011

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“…The reticular nucleus is found lateral to the superior raphe and believed by some to be homologous to the mammalian B9 nucleus (Stuesse, Cruce & Northcutt, 1991; Rodrigo-Angulo, Rodriguez-Veiga & Reinoso-Suárez, 2000). However, a separate pontomesencephalic reticular formation is also present in mammals (Hale & Lowry, 2011), and although the function of this region is not well understood, it does possesses projections to the basal forebrain.…”

Section: Discussionmentioning

confidence: 99%

“…While the raphe system is well established in vertebrates, the reticular nuclei are less consistently defined. There is some suggestion that the reticular nuclei of reptiles may be homologous to the mammalian B9 nucleus (Stuesse, Cruce & Northcutt, 1991; Rodrigo-Angulo, Rodriguez-Veiga & Reinoso-Suárez, 2000). However, a pontomesencephalic reticular formation is also known to be present in rats (Hale & Lowry, 2011), and this latter nucleus may also be homologous to the reticular nuclei in lizards.…”

Section: Introductionmentioning

confidence: 99%

Serotonergic activation during courtship and aggression in the brown anole,Anolis sagrei

Hartline

Smith

Kabelik

2017

PeerJ

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The role of serotonin (5-hydroxytryptamine, 5-HT) in social behavior regulation is not fully understood. While 5-HT release in nuclei of the social behavior network has generally been associated with inhibition of aggressive behavior across multiple classes of vertebrates, less is known about its effects on sexual, especially non-copulatory courtship display behaviors. Furthermore, most research has examined effects at 5-HT release sites, while studies examining the behavioral relevance of source cell populations have generated contradictory findings. This study utilized immunohistochemistry to examine the colocalization of 5-HT with Fos, an immediate early gene product and marker of neural activity, in the raphe and superior reticular nuclei of male brown anoles (Anolis sagrei) exposed to either aggression, courtship, or control social interactions. Supporting previous research, copulation was associated with a decrease in 5-HT activity, while a novel link between 5-HT activity and latency to non-copulatory courtship was also found. Within the aggression group, intensity and frequency of behavior were both associated with decreased 5-HT activity. An effect of social context was also seen, with anoles exposed to either courtship or aggression encounters showing decreased 5-HT activity in certain raphe and superior reticular nuclei populations compared to controls. Interestingly, context effects and behavioral effects were seen at separate brain nuclei, suggesting the presence of separate systems with distinct functional roles.

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“…Second, because hypocretinergic neurons project to cells in the NRGc (Peyron, et al, 1998, Zhang, et al, 2004), it is possible that NRGc excitatory drives to motoneurons are enhanced following the stimulation of the LH. Third, the NPO as well as the cholinergic and monoaminergic systems in the brainstem, which are known to receive numerous projections from hypocretinergic neurons, innervate cells in the NRGc; moreover, monoaminergic neurons in the raphe and locus coeruleus project to motoneurons (Fung and Barnes, 1987, Holmes and Jones, 1994, Holmes, et al, 1994, Jones, 1990, Jones, 1991, Rodrigo-Angulo, et al, 2000, Semba, 1993, Semba, et al, 1990, Shammah-Lagnado, et al, 1987). Thus, the mutually facilitatory interaction between the LH and NRGc may be integrated at diverse synaptic relays at suprasegmental and segmental levels.…”

Section: Discussionmentioning

confidence: 99%

State-dependent control of lumbar motoneurons by the hypocretinergic system

Yamuy¹,

Fung²,

Xi³

et al. 2010

Experimental Neurology

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Neurons in the lateral hypothalamus (LH) that synthesize hypocretins (Hcrt-1 and 2) are active during wakefulness and excite lumbar motoneurons. Because hypocretinergic cells also discharge during phasic periods of rapid eye movement (REM) sleep, we sought to examine their action on the activity of motoneurons during this state. Accordingly, cat lumbar motoneurons were intracellularly recorded, under α-chloralose anesthesia, prior to (control) and during the carbachol-induced REM sleep-like atonia (REMc). During control conditions, LH stimulation induced excitatory postsynaptic potentials (composite EPSP) in motoneurons. In contrast, during REMc, identical LH stimulation induced inhibitory PSPs in motoneurons. We then tested the effects of LH stimulation on motoneuron responses following the stimulation of the nucleus reticularis gigantocellularis (NRGc) which is part of a brainstem-spinal cord system that controls motoneuron excitability in a state-dependent manner. LH stimulation facilitated NRGc stimulation-induced composite EPSP during control conditions whereas it enhanced NRGc stimulation-induced IPSPs during REMc. These intriguing data indicate that the LH exerts a state-dependent control of motor activity. As a first step to understand these results, we examined whether hypocretinergic synaptic mechanisms in the spinal cord were statedependent. We found that the juxtacellular application of Hcrt-1 induced motoneuron excitation during control conditions whereas motoneuron inhibition was enhanced during REMc. These data indicate that the hypocretinergic system acts on motoneurons in a state-dependent manner via spinal synaptic mechanisms. Thus, deficits in Hcrt-1 may cause the coexistence of incongruous motor signs in cataplectic patients, such as motor suppression during wakefulness and movement disorders during REM sleep.

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Serotonergic connections to the ventral oral pontine reticular nucleus: Implication in paradoxical sleep modulation

Cited by 25 publications

References 44 publications

High novelty-seeking predicts aggression and gene expression differences within defined serotonergic cell groups

High novelty-seeking predicts aggression and gene expression differences within defined serotonergic cell groups

Serotonergic activation during courtship and aggression in the brown anole,Anolis sagrei

State-dependent control of lumbar motoneurons by the hypocretinergic system

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