Serotonergic candidate genes and puerperal psychosis: an association study

Kumar, Harshit; Purushottam, Meera; Kubendran, Shobana; Gayathri, Praveena; Mukherjee, Odity; Murthy, A. Ram; Ghosh, Saurabh; Chandra, Prabha S.; Reddy, Y.C. Janardhan; Benegal, Vivek; Brahmachari, Samir K.; Jain, Sanjeev

doi:10.1097/ypg.0b013e3280ae6cc3

Cited by 27 publications

(19 citation statements)

References 63 publications

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“…However, these two studies are not entirely comparable because different scales were used for PPD diagnosis, and the postpartum period for each study was different. Additionally, our findings are partially corroborated by several studies that found an association between the presence of the 5-HTTLPR*S [6,[15][16][17]22] and 5-HTTVNTR*10 alleles [42] with mood disorders; in our study, the L-12/L-12 diplotype was associated with a lower BDI score, indicating that this diplotype could partially protect an individual from developing PPD.…”

Section: Discussionsupporting

confidence: 79%

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Evaluation of the 5-HTTLPR and 5-HTTVNTR Polymorphisms in the Serotonin Transporter Gene in Women with Postpartum Depression

Zimmermann-Peruzatto¹,

Almeida²,

Lucion³

et al. 2012

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Objective: The purpose of the present study was to evaluate the association between the 5-HTTLPR and 5-HTTVNTR polymorphisms in the serotonin transporter gene (SLC6A4) in Brazilian women with diagnosed postpartum depression (PPD) and the presence of depressive symptoms. Method: The cohort consisted of 128 white women who were characterized based on skin color and morphological characteristics. The Beck Depression Inventory was used to diagnose PPD and to score the depressive symptoms. The 5-HTTLPR and 5-HTTVNTR polymorphisms were analyzed by PCR-based methods. Results: No association was observed between the PPD diagnosis and either the 5-HTTLPR (p = 0.48) or the 5-HTTVNTR (p = 0.77) polymorphism. When the polymorphisms were analyzed together with haplotype data, the analyses demonstrated that women carriers of the L-12/L-12 diplotype have lower Beck Depression Inventory scores than women carrying other diplotypes (p = 0.04). Discussion: Few studies have investigated the association of SLC6A4 polymorphisms with PPD, and the role of 5-HTTLPR and 5-HTTVNTR polymorphisms in PPD susceptibility has not been established to date. Therefore, our findings link the haplotypes of these two variants with depression symptoms, thereby contributing to our understanding of PPD susceptibility.

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Section: Discussionsupporting

confidence: 79%

“…However, in a previous study, the increased frequency of the 5-HTTVNTR*12 allele was observed in subjects with bipolar disorder but not in subjects diagnosed with major depression [19]. Kumar et al [42] observed an association between the 5-HTTVNTR*10 allele and puerperal psychosis.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the 5-HTTLPR and 5-HTTVNTR Polymorphisms in the Serotonin Transporter Gene in Women with Postpartum Depression

Zimmermann-Peruzatto¹,

Almeida²,

Lucion³

et al. 2012

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“…In contrast, other studies (32,33) have reported that the 1354C/T polymorphism in the HTR2A gene is associated with BD. Therefore, these research results are either inconclusive or inconsistent.…”

Section: Introductionmentioning

confidence: 67%

Meta-analysis of the HTR2A–1354C/T polymorphism in schizophrenia and bipolar disorder

Tan

et al. 2013

Acta Neuropsychiatr.

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analysis of the HTR2A-1354C/T polymorphism in schizophrenia and bipolar disorder.Objective: Schizophrenia (SCZ) and bipolar disorder (BD) are common psychotic disorders, which show some overlaps in genetic aetiology. Researchers have conducted a number of studies to investigate the relationship between SCZ and the 1354C/T genetic polymorphism of 5-hydroxytryptamine receptor 2A (HTR2A-1354C/T), as well as the associations between BD and the HTR2A-1354C/T polymorphism. However, the results were conflicting. To provide a more robust estimate about the effects of the HTR2A-1354C/T polymorphism on the risk of these two psychotic disorders, we performed this meta-analysis. Methods: We used the pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) to investigate the relationships between SCZ and the 1354C/T polymorphism of HTR2A, as well as the associations between BD and HTR2A-1354C/T. Publication bias was tested by Begg's test and inverted funnel plot, and heterogeneity was checked by Cochran's Q statistic and the inconsistency index (I 2 ). Results: Eight studies were concerned with SCZ, analysing a cumulative total of 2953 cases and 3153 controls; six papers studied BD, using a total of 923 cases and 928 controls. There was no significant association found between HTR2A-1354C/T and SCZ in the overall population (T allele vs. C allele, OR 5 1.035, 95% CI 0.912-1.175, p 5 0.596) or in the subgroups Caucasian population and Asian population. Moreover, there was no significant association between the HTR2A-1354C/T polymorphism and BD in the overall population (T allele vs. C allele, OR 5 1.038, 95% CI 5 0.607-1.772, p 5 0.892). Conclusion: On the basis of these results, the HTR2A-1354C/T polymorphism is unlikely to be a risk factor for SCZ and BD.Summations > There is no significant association between HTR2A-1354C/T and schizophrenia (SCZ) in the overall population using five genetic models. > There is no significant association between HTR2A-1354C/T polymorphism and SCZ in the subgroups of Caucasian population and Asian population using five genetic models. > There is no significant association between the HTR2A-1354C/T polymorphism and bipolar disorder using five genetic models.Considerations > We may have lost the opportunity to obtain a larger sample size and increase statistical power because of the exclusion of all studies published in other languages. 311> The SCZ and BD diagnostic standard, as well as the source of controls, were not found to be similar in our study, suggesting selection bias in our study. > There is only one article concerning the Asian population and SCZ, and all of the researches of BP areCaucasian. This might imply that the representation of our results was not prominent enough. More research on other ethnicities and different countries should be added into future studies.

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“…Efforts are currently underway to undertake a sufficiently-powered genome-wide association study (GWAS) in bipolar affective postpartum psychosis, but as yet these have not yielded significant findings. Candidate gene-led studies in PP have focussed upon serotonergic system genes given the therapeutic efficacy of antipsychotics; one study provided suggestive evidence for association within the serotonin transporter and serotonin 2A receptor genes[24]. However, candidate gene association studies, which focus upon genes of likely biological relevance to a condition, often have low replication rates and are inevitably biased by our very limited current knowledge base[25].…”

Section: Current Approaches To Understanding Postpartum Psychosis Andmentioning

confidence: 99%

Understanding the pathophysiology of postpartum psychosis: Challenges and new approaches

Davies

2017

WJP

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Postpartum psychosis is a severe psychiatric condition which affects 1-2 of every 1000 mothers shortly after childbirth. Whilst there is convincing evidence that the condition is precipitated by a complex combination of biological and environmental factors, as yet the pathophysiological mechanisms remain extremely poorly defined. Here, I critically review approaches that have been, or are being, employed to identify and characterise such mechanisms; I also review a recent animal model approach, and describe a novel biological risk model that it suggests. Clarification of biological risk mechanisms underlying disorder risk should permit the identification of relevant predictive biomarkers which will ensure that “at risk” subjects receive prompt clinical intervention if required.

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Serotonergic candidate genes and puerperal psychosis: an association study

Abstract: The association between polymorphisms in serotonergic genes (SERT and 5-HT2A, 5-HT2C) suggests that these genetic factors can modulate vulnerability to puerperal psychosis in female bipolar participants.

Cited by 27 publications

References 63 publications

Evaluation of the 5-<i>HTTLPR</i> and 5-<i>HTTVNTR</i> Polymorphisms in the Serotonin Transporter Gene in Women with Postpartum Depression

Evaluation of the 5-<i>HTTLPR</i> and 5-<i>HTTVNTR</i> Polymorphisms in the Serotonin Transporter Gene in Women with Postpartum Depression

Meta-analysis of the HTR2A–1354C/T polymorphism in schizophrenia and bipolar disorder

Understanding the pathophysiology of postpartum psychosis: Challenges and new approaches

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Serotonergic candidate genes and puerperal psychosis: an association study

Abstract: The association between polymorphisms in serotonergic genes (SERT and 5-HT2A, 5-HT2C) suggests that these genetic factors can modulate vulnerability to puerperal psychosis in female bipolar participants.

Cited by 27 publications

References 63 publications

Evaluation of the 5-&lt;i&gt;HTTLPR&lt;/i&gt; and 5-&lt;i&gt;HTTVNTR&lt;/i&gt; Polymorphisms in the Serotonin Transporter Gene in Women with Postpartum Depression

Evaluation of the 5-&lt;i&gt;HTTLPR&lt;/i&gt; and 5-&lt;i&gt;HTTVNTR&lt;/i&gt; Polymorphisms in the Serotonin Transporter Gene in Women with Postpartum Depression

Meta-analysis of the HTR2A–1354C/T polymorphism in schizophrenia and bipolar disorder

Understanding the pathophysiology of postpartum psychosis: Challenges and new approaches

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Evaluation of the 5-<i>HTTLPR</i> and 5-<i>HTTVNTR</i> Polymorphisms in the Serotonin Transporter Gene in Women with Postpartum Depression

Evaluation of the 5-<i>HTTLPR</i> and 5-<i>HTTVNTR</i> Polymorphisms in the Serotonin Transporter Gene in Women with Postpartum Depression