Serotonergic and dopaminergic effects on yawning in the cat

Marini, James L.

doi:10.1016/0091-3057(81)90010-1

Cited by 9 publications

(3 citation statements)

References 26 publications

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“…1983), suggesting antagonist activity. Furthermore, (-)-3-PPP-induced suppression of locomotor activity is insensitive to D2 blockade (Stahle and Ungerstedt 1987), and the (-)-enantiomer, but not (+)-3-PPP, is a weak serotonin antagonist (Arnt et al 1983) and this may also influence yawning behaviour (Marini 1981;Yamada and Furukawa 1981).…”

Section: Discussionmentioning

confidence: 99%

Apomorphine-induced yawning in rats is abolished by bilateral 6-hydroxydopamine lesions of the substantia nigra

1987

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Apomorphine-induced yawning was studied in male rats with bilateral 6-hydroxydopamine lesions of the substantia nigra. Apomorphine 10, 20 and 50 micrograms/kg SC induced dose-dependent yawning in unoperated controls and animals with sham lesions. In the lesioned animals (in which the mean striatal dopamine depletion was 67%), the maximum yawning response rate was greatly attenuated with no evidence that the dose response curve was shifted in either direction. Furthermore, blockade of yawning in the lesioned animals was not simply due to suppression by other stereotyped behaviours, since there was no evidence of increased sniffing or chewing in these animals. These data provide further support for the hypothesis that apomorphine-induced yawning is mediated by dopamine autoreceptors and requires intact nigrostriatal projections.

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Section: Discussionmentioning

confidence: 99%

Apomorphine-induced yawning in rats is abolished by bilateral 6-hydroxydopamine lesions of the substantia nigra

1987

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“…Among the carnivores, yawning is frequent in the fissipeds, both the Felidae (cat family) and Canidae (dog family) (Baenninger, 1987;Ferrari et aI., 1955;Konorski, 1967;Marini, 1981). It has also been found in pinnipeds (seals, sea lions, walruses).…”

Section: Phylogenetic Aspects Of Yawningmentioning

confidence: 99%

“…Both cholinergic (Cowan, 1978) and dopaminergic (Mogilnicka & Klimek, 1977) components were subsequently discovered. Low doses of apomorphine or other dopamine agonists Marini, 1981;Mogilnicka & Klimek, 1977) induce yawning with stretching, chewing movements, and penile erection in male rats. Mogilnicka and Klimek suggested that treatment with low doses of dopamine agonists activates presynaptic inhibitory dopamine receptors (so-called autoreceptors).…”

Section: Drugs That Induce Yawningmentioning

confidence: 99%

On yawning and its functions

1997

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The forms and behavioral correlates of yawning are described, and the phylogenetic and ontogenetic aspects of the act are examined with particular attention to its possible functions. Much evidence supports the view that yawning is an important mediator of behavioral arousal levels, a view that is further strengthened by a review of endocrine, neurotransmitter, and pharmacological mechanisms of yawning: A major function of yawning appears to involve maintenance or increase of arousal when environments provide relatively little stimulation.

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Relation between yawning behavior and central serotonergic neuronal system in rats

Okuyama

Shimamura

Hashimoto

et al. 1987

Naunyn-Schmiedeberg's Arch Pharmacol

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Subcutaneously (s.c.) administered apomorphine (0.0125-0.4 mg/kg) or physostigmine (0.025-0.4 mg/kg) to rats elicited yawning. The dose-response curves were bell-shaped. The peak effects of apomorphine and physostigmine were observed with a dose of 0.1 mg/kg of each drug. Yawning elicited by apomorphine (0.1 mg/kg) or physostigmine (0.1 mg/kg) was reduced by intraperitoneally (i.p.) administered 5-hydroxytryptophan (5-HTP, 50-200 mg/kg, given 30 min before). Yawning elicited by apomorphine but not by physostigmine was enhanced by p-chlorophenylalanine (p-CPA, 25-400 mg/kg i.p., given 24 h before). Apomorphine elicited but not physostigmine-elicited yawning was enhanced by pretreatment with 5,7-dihydroxytryptamine (5,7-DHT, 8 micrograms/rat, given 14 days before into the dorsal raphe). This treatment led to a 35% depletion of serotonin (5-HT) in the striatum. 5-HTP, p-CPA or 5,7-DHT given alone did not elicit yawning. Bilateral, intrastriatal microinjection of apomorphine (1.5-50 micrograms/site) but not physostigmine (5-50 micrograms/site) elicited yawning. The dose-response curve was also bell-shaped. These results indicate that central serotonergic pathways play an important role in modulating drug-elicited yawning in rats.

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Serotonergic and dopaminergic effects on yawning in the cat

Cited by 9 publications

References 26 publications

Apomorphine-induced yawning in rats is abolished by bilateral 6-hydroxydopamine lesions of the substantia nigra

Apomorphine-induced yawning in rats is abolished by bilateral 6-hydroxydopamine lesions of the substantia nigra

On yawning and its functions

Relation between yawning behavior and central serotonergic neuronal system in rats

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