Serotonergic and cognitive impairment in impulsive aggressive personality disordered offenders: are there implications for treatment?

Dolan, Mairead; Deakin, William J.; Roberts, Nicola; Anderson, Ian

doi:10.1017/s0033291701004688

Cited by 63 publications

(51 citation statements)

References 45 publications

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“…cognitive functions [9] . It also controls impulsivity [10] , extreme violence, hostility, and aggression [4,[11][12][13] , which are behaviors and traits frequently disturbed in ADHD. Low levels of central 5-HT have been associated with ADHD, while peripheral indices of central 5-HT function (platelet 5-HT and whole blood tryptophan levels) were found to be lower, unaltered, or increased in ADHD [5] .…”

Section: Platelet Serotonin Concentration In Children Withmentioning

confidence: 99%

“…Blood platelets have similarities and differences with CNS 5-HT neurons [14][15][16] . Platelet 5-HT concentration has been found to be altered in impulsive and aggressive behavior [12][13][14] . To our knowledge, there are no studies that have examined the association between platelet 5-HT and characteristic symptoms of ADHD.…”

Section: Platelet Serotonin Concentration In Children Withmentioning

confidence: 99%

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Platelet Serotonin Concentration in Children with Attention-Deficit/Hyperactivity Disorder

Novković¹,

Rudan²,

Pivac³

et al. 2009

Neuropsychobiology

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Background: Attention-deficit/hyperactivity disorder (ADHD) is a psychiatric disorder highly prevalent in children. The neurobiology of ADHD is still not clear, but is assumed to be related to disturbances in catecholaminergic and serotonergic (5-hydroxytryptamine, 5-HT) systems. Peripheral indices of central 5-HT function were shown in recent studies to be lower, unaltered, or increased in ADHD. Methods: The study determined platelet 5-HT concentration in 84 medication-free 9-year-old (range 4–14 years) boys and girls with DSM-IV diagnosis of ADHD, subdivided according to the different symptoms (inattention, hyperactivity, and impulsivity) and clinical ADHD subtypes (predominantly hyperactive, predominantly inattentive, and combined subtype), and in 30 age- and sex-matched healthy controls. Results: Children with ADHD had similar platelet 5-HT concentrations to control children. Platelet 5-HT concentration did not differ between boys and girls, or between children with a hyperactive, inattentive, or combined subtype of ADHD. In children with ADHD there was a significant positive correlation between platelet 5-HT concentration and impulsive symptoms, but not with symptoms of inattention or hyperactivity.Platelet 5-HT concentration wassignificantly higher in impulsive compared to non-impulsive children with ADHD. Conclusion: The data provide preliminary evidence that increased platelet 5-HT concentration might be a trait marker predictive of impulsivity in ADHD.

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Section: Platelet Serotonin Concentration In Children Withmentioning

confidence: 99%

Section: Platelet Serotonin Concentration In Children Withmentioning

confidence: 99%

Platelet Serotonin Concentration in Children with Attention-Deficit/Hyperactivity Disorder

Novković¹,

Rudan²,

Pivac³

et al. 2009

Neuropsychobiology

View full text Add to dashboard Cite

show abstract

“…Offenders whose crimes seem to be unusually impulsive rather than being carefully planned are especially likely to exhibit serotonergic malfunctioning. Childhood conduct disorders and antisocial personality have also both been linked to below normal functioning of the serotonergic system (Coccaro et al 1997;Dolan et al 2002).…”

Section: Serotoninmentioning

confidence: 99%

A Theory Explaining Biological Correlates of Criminality

Ellis

2005

European Journal of Criminology

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Despite major advances in understanding the biological basis of human behaviour, the most popular theories of criminal behaviour remain restricted to those that consider only learning and social environmental variables. All of these strictly environmental theories have difficulty explaining why neurological, hormonal, and other biological factors would be related to criminal behaviour, yet evidence for links between such biological factors and criminality has grown. This article puts forward a theory that takes account of biological as well as environmental factors, and predicts that variables such as age, gender and social status will be associated with offending probabilities. It is argued that male sex hormones operating on the human brain increase the probability of competitive/victimizing behaviour. This type of behaviour (or behavioural tendency) is hypothesized to exist along a continuum, with ‘crude’ (criminal) forms at one end and ‘sophisticated’ (commercial) forms at the other. Individuals with the greatest capacities to learn and plan will move rapidly after puberty from criminal to non-criminal forms of competitive/victimizing behaviour. The theory predicts among other things that serious criminality will be concentrated in adolescent and young adult males of low social status. Evidence is reviewed on links between criminality and various biological variables, including testosterone, mesomorphy, maternal smoking during pregnancy, hypoglycemia, epilepsy, altered heart rate and skin conductivity, cortisol, serotonin, monoamine oxidase, and certain brainwave patterns.

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“…In contrast, Prolactin has evidenced a minor response to the agonists of serotonin in individuals with PD (Dolan, Deakin, Roberts, & Anderson, 2002), which constitutes potential biomarkers in psychopathology (Dolan, Deakin, Roberts, & Anderson, 2002).…”

Section: Biomarkers In Personality Disordersmentioning

confidence: 96%

Potential biomarkers in personality disorders: current state and future research

Valencia

Arias

2016

Int. j. psychol. res.

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Serotonergic and cognitive impairment in impulsive aggressive personality disordered offenders: are there implications for treatment?

Cited by 63 publications

References 45 publications

Platelet Serotonin Concentration in Children with Attention-Deficit/Hyperactivity Disorder

Platelet Serotonin Concentration in Children with Attention-Deficit/Hyperactivity Disorder

A Theory Explaining Biological Correlates of Criminality

Potential biomarkers in personality disorders: current state and future research

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