Serosurvey for Middle East respiratory syndrome coronavirus antibody in dromedary camels and human patients at a secondary care hospital, Illela, Northwest Nigeria

Salam, Samson Polycarp; Kia, G.S.N.; Oladayo, F. O.; Ugochukwu, Iniobong Chukwuebuka Ikenna

doi:10.1007/s00580-022-03351-3

Cited by 2 publications

(2 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A vast majority of camels in Nigeria are raised extensively, where they are exposed to extrinsic environmental factors suitable for vector proliferation. Recent studies have highlighted a predisposition of camels to zoonotic pathogens such as influenza A virus [ 29 ], MERS-CoV [ 30 ], Rift Valley fever virus [ 31 ], and hepatitis E virus [ 32 ]. CCHFV is an arboviral infection that can be categorized under acute undifferentiated febrile illness (AFI) in humans with unspecified clinical manifestations ranging from fever, headache, and malaise [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Investigating Crimean–Congo haemorrhagic fever virus seropositivity in camels and human behavioural risks in an abattoir in Nigeria

Adamu,

Onoja,

Ugbodu

et al. 2024

Epidemiol. Infect.

View full text Add to dashboard Cite

Crimean–Congo haemorrhagic fever virus (CCHFV) is an emerging viral pathogen with pandemic potential that is often misdiagnosed. Case fatality in low-resource settings could be up to 40% due to close contact between animals and humans. A two-year cross-sectional study was conducted in Fagge abattoir, Kano State, Nigeria, to estimate the seropositivity of CCHFV in camels using a commercial multi-species competitive enzyme-linked immunosorbent assay (ELISA). A closed-ended questionnaire was administered to the abattoir workers to assess their awareness, mitigation, and behavioural practices associated with CCHF. Of the 184 camels tested, 179 (97%) were seropositive for CCHFV (95% confidence interval (CI): 93.77, 99.11). The median (interquartile range (IQR)) age of respondents was 41 (35–52), with 62% having no education. Respondents had little knowledge about CCHFV and the concept of zoonotic disease. In this study, the high estimated prevalence of antibodies to CCHFV in camels highlights the heightened risk of transmission of CCHFV in Nigeria. Similarly, a concerning lack of knowledge and inadequate preventive practices, alongside a prevalence of high-risk behaviours associated with CCHF among abattoir workers, were noted in this study. Thus, there is an urgent need for comprehensive public health education and collaborative One Health strategies to avert the threats of spillover events.

show abstract

Section: Discussionmentioning

confidence: 99%

Investigating Crimean–Congo haemorrhagic fever virus seropositivity in camels and human behavioural risks in an abattoir in Nigeria

Adamu,

Onoja,

Ugbodu

et al. 2024

Epidemiol. Infect.

View full text Add to dashboard Cite

show abstract

“…The role of camels as a MERS-CoV reservoir is supported by high prevalence of MERS-CoV antibodies among dromedary camels from African countries (Ethiopia, Kenya, Nigeria, Sudan, Egypt and Tunisia) the Arabian Peninsula (Jordan, Oman, Qatar and United Arab Emirates) and South Asia [ 4 , 8 – 16 ]. Cross sectional studies of MERS-CoV in dromedary camels in Africa and Middle East have regularly found high prevalence of MERS-CoV neutralizing antibodies in camel populations.…”

Section: Introductionmentioning

confidence: 99%

A longitudinal study of Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels

Abdelazim,

Abdelkader,

Ali

et al. 2023

BMC Vet Res

View full text Add to dashboard Cite

Background Middle East respiratory syndrome coronavirus (MERS-CoV) was identified in humans in 2012. Since then, 2605 cases and 937 associated deaths have been reported globally. Camels are the natural host for MERS-CoV and camel to human transmission has been documented. The relationship between MERS-CoV shedding and presence of neutralizing antibodies in camels is critical to inform surveillance and control, including future deployment of camel vaccines. However, it remains poorly understood. The longitudinal study conducted in a closed camel herd in Egypt between December 2019 and March 2020 helped to characterize the kinetics of MERS-CoV neutralizing antibodies and its relation with viral shedding. Results During the 100-day longitudinal study, 27 out of 54 camels (50%) consistently tested negative for presence of antibodies against MERS-CoV, 19 (35.2%) tested positive and 8 (14.8%) had both, positive and negative test results. Fourteen events that could be interpreted as serological indication of probable infection (two seroconversions and twelve instances of positive camels more than doubling their optical density ratio (OD ratio) in consecutive samples) were identified. Observed times between the identified events provided strong evidence (p = 0.002) against the null hypothesis that they occurred with constant rate during the study, as opposed to clustering at certain points in time. A generalized additive model showed that optical density ratio (OD ratio) is positively associated with being an adult and varies across individual camels and days, peaking at around days 20 and 90 of the study. Despite serological indication of probable virus circulation and intense repeated sampling, none of the tested nasal swab samples were positive for MERS-CoV RNA, suggesting that, if the identified serological responses are the result of virus circulation, the virus may be present in nasal tissue of infected camels during a very narrow time window. Conclusions Longitudinal testing of a closed camel herd with past history of MERS-CoV infection is compatible with the virus continuing to circulate in the herd despite lack of contact with other camels. It is likely that episodes of MERS-CoV infection in camels can take place with minimal presence of the virus in their nasal tissues, which has important implications for future surveillance and control of MERS-CoV in camel herds and prevention of its zoonotic transmission.

show abstract

Serosurvey for Middle East respiratory syndrome coronavirus antibody in dromedary camels and human patients at a secondary care hospital, Illela, Northwest Nigeria

Cited by 2 publications

References 37 publications

Investigating Crimean–Congo haemorrhagic fever virus seropositivity in camels and human behavioural risks in an abattoir in Nigeria

Investigating Crimean–Congo haemorrhagic fever virus seropositivity in camels and human behavioural risks in an abattoir in Nigeria

A longitudinal study of Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels

Contact Info

Product

Resources

About