Seroreactivity to Cutaneous Human Papillomaviruses among Patients with Nonmelanoma Skin Cancer or Benign Skin Lesions

Andersson, Kristin; Waterboer, Tim; Kirnbauer, Reinhard; Slupetzky, Katharina; Iftner, Thomas; Villiers, Ethel Michele De; Forslund, Ola; Pawlita, Michael; Dillner, Joakim

doi:10.1158/1055-9965.epi-07-0405

Cited by 78 publications

(125 citation statements)

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“…These results correspond exactly to our findings for the 'older adults' (.34 years) from the German HPV seroprevalence study , with the most frequent b-HPV type being HPV-8 (followed by , and HPV-4 and -65 the two most prevalent c-HPV types. The comparison of these results with other studies is hampered by different numbers of HPV types tested, and partly by methodological issues, but in two HPV and SCC case-control studies conducted in the USA (Karagas et al, 2006) and Sweden (Andersson et al, 2008), each with eight b-HPV types tested, HPV-8, -38 and -15 were the most frequent among the controls. These data demonstrate that the distribution of (b-)HPV types may be very similar worldwide, at least in populations of largely European descent.…”

Section: Discussionmentioning

confidence: 91%

“…Multiplex serology has been well validated (Andersson et al, 2008;Casabonne et al, 2007;Karagas et al, 2006; and is a state-of-the-art technique for highthroughput analysis of sera for antibodies to multiple antigens. This makes methodological issues very unlikely as an explanation for any of our observations, and the differences found for b-and c-HPV types (for example, regarding the mean number of seropositive types) underscore the specificity of our findings.…”

Section: Discussionmentioning

confidence: 99%

“…Several recent epidemiological studies support an association between the presence of b-HPV DNA and SCC Struijk et al, 2003Struijk et al, , 2006. Antibodies against the major capsid protein L1 are generally considered to be markers of past or present HPV exposure, and increased seroreactivity to skin HPV types has been reported to be associated with cutaneous SCC (Andersson et al, 2008;, reviewed by Casabonne et al, 2007.…”

Section: Introductionmentioning

confidence: 99%

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Antibody responses to 26 skin human papillomavirus types in the Netherlands, Italy and Australia

Waterboer

Neale

Michael

et al. 2009

Journal of General Virology

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Solar UV radiation is the main risk factor for cutaneous squamous cell carcinoma (SCC), but infections with skin human papillomavirus (HPV) types have also been linked to the development of SCC. Little is known about the natural history of these infections and whether the seroprevalence of skin HPV types is affected by ambient or individual levels of sun exposure. This study investigated this by analysing sera for antibodies to 26 skin HPV types from five phylogenetic genera obtained from 807 healthy individuals from the Netherlands, Italy and Australia, countries with strong differences in sunlight intensity. Overall HPV seroprevalence was similar across the three countries (50-57 % for b-HPV types, 40-48 % for c-HPV types), and the most frequent b-HPV and c-HPV types were the same in all countries. The highest seroprevalences for 24 of the 26 skin HPV types were observed in Italy (14 types) and Australia (ten types). Seroprevalence among men was generally higher than among women, and the male sex was significantly associated with both b-HPV [odds ratio (OR) 2.81, 95 % confidence interval (CI) 1.64-4.82] and c-HPV (OR 2.42, 95 % CI 1.40-4.18) antibodies in Australia. The only measure of sun sensitivity or UV exposure significantly associated with skin HPV seroprevalence was found for weekend sun exposure in Australia and b-HPV antibodies. It was concluded that type spectra and HPV seroprevalence are similar in countries with different sunlight intensity, and that levels of UV exposure do not play a strong role in the development of skin HPV antibodies in this study population.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antibody responses to 26 skin human papillomavirus types in the Netherlands, Italy and Australia

Waterboer

Neale

Michael

et al. 2009

Journal of General Virology

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“…Recent epidemiological studies suggest that these betaPV types also play a role in the pathogenesis of cutaneous SCC in the general population. Seroreactivity to betaPV types has been found to be associated with non-melanoma skin cancer (Andersson et al, 2008;Feltkamp et al, 2003;Karagas et al, 2006;Struijk et al, 2006). Also, associations have been found between the detection of betaPV DNA in plucked eyebrow hairs and actinic keratoses (AK) (Boxman et al, 2001;Struijk et al, 2006) and cutaneous SCC Struijk et al, 2003Struijk et al, , 2006.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and associated factors of betapapillomavirus infections in individuals without cutaneous squamous cell carcinoma

Koning

Weissenborn

Abeni

et al. 2009

Journal of General Virology

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Betapapillomavirus (betaPV) infections are often associated with squamous-cell carcinoma (SCC) and the prevalence of betaPV infections in (immunosuppressed) SCC patients is known to be high. The distribution and possible associated factors of betaPV infections in the general population, however, are largely unknown. To address this issue, betaPV infection was studied in 1405 SCC-free immunocompetent (n5845) and immunosuppressed (n5560) individuals from six countries of different latitudes. A standard study protocol was used to obtain information about age, sex, UVirradiation and skin type, and from all participants eyebrow hairs were collected for detection and genotyping of 25 established betaPV types using the PM-PCR reverse hybridization assay (RHA) method. The frequency of betaPV-positive participants ranged from 84 to 91 % in the immunocompetent population with HPV23 as the most prevalent type, and from 81 to 98 % in the immunosuppressed population with HPV23 as the most or the second most prevalent type. The median number of infecting betaPV types ranged from four to six in the immunocompetent and from three to six in the immunosuppressed population. Increasing age in the immunocompetent participants and (duration of) immunosuppression in the immunosuppressed patients were associated with betaPV infection. In both groups, sex, skin phototype, sunburns and sun-exposure were not consistently associated with betaPV infection. This study demonstrates that betaPV infections are also highly prevalent in SCC-free individuals, with similar HPV types prevailing in both immunocompetent and immunosuppressed persons. Age and (duration of) immunosuppression were identified as betaPV infection-associated factors, whereas characteristics related to sun exposure and skin type were not. 3Present address:

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“…19 These findings were consistent with a study in which HPV-DNA from the beta genus of species 2 predominated in SCC compared to healthy skin samples. 37 The natural history of cutaneous HPV types is not well understood 24 and the concordance between HPV-DNA in skin biopsies 18 or in plucked hairs 17 and antibody detection has been low. In comparison to the clear results relating HPV 16 and 6 to self-reported histories of cervical cytological abnormalities or genital warts, the role of any of the 34 HPV types examined in relation to SCC remains unclear.…”

Section: Discussionmentioning

confidence: 99%

A case‐control study of cutaneous squamous cell carcinoma among Caucasian organ transplant recipients: The role of antibodies against human papillomavirus and other risk factors

Casabonne

Lally

Mitchell

et al. 2009

Intl Journal of Cancer

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A case-control study was conducted in 140 people with histology proven cutaneous squamous cell carcinoma (SCC) and 454 controls, nested within 2 cohorts of organ transplant recipients (OTR) recruited in London and Oxford between 2002 and 2006. All participants had a skin examination, completed a questionnaire and had serum tested for antibodies against the L1 antigen of 34 HPV types using Luminex technology. SCC was more common in men than women (odds ratio [OR] 5 1.7, 95% confidence interval [CI]: 1.1-2.8, p 5 0.02) and in people with susceptibility to burn easily (OR 5 3.0, 95%CI: 1.9-4.8; p < 0.001). The risk increased with increasing age (p-trend < 0.001), increasing time since transplant (p-trend < 0.001), increasing self-reported number of sunburns as a child (ptrend < 0.001) and with the presence of viral warts (p < 0.001). As expected, antibodies against HPV 16 were associated with a selfreported history of an abnormal cervical smear among women (OR 5.1, 95%CI: 2.6-10.2) and antibodies against HPV 6 were associated with a self-reported history of genital warts (OR 4.0, 95%CI: 2.2-7.2). However, no clear associations between any of the HPV types examined (including cutaneous betaHPVs) and SCC were identified. For example, the seroprevalence of HPV 5 was 15% among cases and 9% among controls (p 5 0.09) and the seroprevalence of HPV 8 was 23% among cases and 21% among controls (p 5 0.6). Nor was seropositivity to multiple types associated with SCC. These serological data do not provide evidence for a role for HPV in the aetiology of cutaneous SCC among OTR in two UK-based populations. ' 2009 UICC Key words: Epidemiology; human papillomavirus (HPV); serology; cutaneous squamous cell carcinoma (SCC); organ transplant recipients Immunosuppressed organ transplant recipients (OTR) have a higher risk of non-melanoma skin cancer than the general population. Furthermore, cutaneous squamous cell carcinomas (SCC) occur significantly more frequently than basal cell carcinomas (BCC), reversing the ratio usually found in the general population (4:1). 1,2 Ultraviolet radiation (UVR) is the main established risk factor both for SCC and BCC. 3 The strength of the association between SCC and immunosuppression, particularly after solid organ transplantation, parallels that seen for other virally associated posttransplant cancers; certain HPV types have long been proposed as potential candidates. 4 However, while the oncogenic mechanism of HPV in cancers of the uterine cervix is well-understood and the causative association is now established, it remains uncertain what role, if any, HPV plays in the aetiology of skin cancer.DNA of cutaneous HPV appears to be ubiquitous and persistent in the skin and hair follicles of healthy individuals. 5,6 Higher prevalence of cutaneous HPV-DNA has been found in the normal skin of immunosuppressed compared to immunocompetent people 7 and putative novel types are often detected. 5 Studies relying on HPV-DNA detection confront problems not only of contamination, a major consideration given t...

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Seroreactivity to Cutaneous Human Papillomaviruses among Patients with Nonmelanoma Skin Cancer or Benign Skin Lesions

Cited by 78 publications

References 37 publications

Antibody responses to 26 skin human papillomavirus types in the Netherlands, Italy and Australia

Antibody responses to 26 skin human papillomavirus types in the Netherlands, Italy and Australia

Prevalence and associated factors of betapapillomavirus infections in individuals without cutaneous squamous cell carcinoma

A case‐control study of cutaneous squamous cell carcinoma among Caucasian organ transplant recipients: The role of antibodies against human papillomavirus and other risk factors

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