Seroprevalencia de infección por Leptospira en habitantes de barrios periféricos de Cali.

Ferro, Beatriz E.; Rodríguez, Ana Lucía; Pérez, Maurício de Andrade; Travi, Bruno L.

doi:10.7705/biomedica.v26i2.1414

Cited by 26 publications

(24 citation statements)

References 16 publications

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“…The confirmation obtained in this study by means of histopathological and molecular methods and its connection with previous Colombian reports of rodents trapped in piggeries (6) and general urban prevalence reports of human leptospirosis, 11% in Medellin City (13), 23.3% in the Cauca Valley (14) and 12.5% in the region of Urabá (15) underlines the plausible importance of leptospirosis for public health in Colombia. Human outbreaks in 1995 (16) related to rainy seasons, floods and domestic rat infestation, with a mortality rate higher than 17%, and an animal outbreak among susceptible Cebidae (17) support the role of rats as important reservoirs for pathogenic leptospires that might cause human leptospirosis in Colombia.…”

Section: Discussionsupporting

confidence: 61%

Alteraciones histopatológicas en ratas naturalmente infectadas con Leptospira

et al. 2012

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Introduction:Histopathological changes by Leptospira in naturally infected rodent reservoirs have been poorly described. Objective: The aim of the current study is to describe renal histopathology associated with leptospirosis infection of naturally infected rodents captured in the urban area of the city of Medellin, Colombia. Materials and methods: We performed hematoxilin-eosin (H-E) on kidney samples collected from 254 captured rodents. The positive samples were processed by Warthin Starry (W-S) staining and PCRLipL32. Results: Fifty one rodent kidneys showed H-E histopathological changes that consisted of inflammatory infiltrate with lympho-plasmocitary cells and histiocytes. We performed W-S staining and PCR-LipL32 to 67 kidney samples, including the 51 that had shown detectable changes by H-E and 16 (8%) of 203 rodents with negative results. Eight of the samples that tested positive for H-E (15.7%) were also positive for W-S staining. All negative for H-E were also negative for W-S staining. Of the W-S positive samples also tested for culture only three tested positive for both. Additionally, 47 (92.1%) samples positive for H-E were positive for PCR; while eleven of the 16 (68.8%) negative for H-E were positive for PCR. The samples positive for PCR were subsequently tested for culture and 11 (23.4%) were positive. Seven samples were positive for PCR and W-S and three were positive for PCR, W-S and culture. All of the PCR-LipL32 fragments were sequenced and showed specific amplicons for L. interrogans. Conclusions:The Leptospira infection was confirmed in all of the animals tested. The only histological kidney lesion attributable to leptospiral infection in the reservoir was interstitial nephritis.

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Section: Discussionsupporting

confidence: 61%

Alteraciones histopatológicas en ratas naturalmente infectadas con Leptospira

et al. 2012

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“…Es una enfermedad con un menor número de casos reportados si se compara con otros síndromes febriles, como dengue, malaria y hepatitis. Sin embargo, ha cobrado mayor interés para las autoridades sanitarias, especialmente por el incremento de casos registrados durante las temporadas de lluvia e inundaciones presentadas en Colombia (10,11,(17)(18)(19)(20)(21).…”

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Comportamiento de la vigilancia epidemiológica de la leptospirosis humana en Colombia, 2007-2011

et al. 2012

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“…La enfermedad se asocia con ambientes rurales y actividades laborales donde se tiene contacto con animales infectados, no obstante, el deterioro de las condiciones sanitarias en las zonas periurbanas y urbanas, recientemente ha favorecido su diseminación [3,6]. El cambio climático y en particular las lluvias y el fenómeno del niño también han influido en la ocurrencia de esta enfermedad [4].…”

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