Seroprevalencia De Hepatitis E en Trabajadores de Fincas Porcícolas del Valle de Aburrá 2011-2012

Betancur, Carlos Alberto; Mejía, María Victoria; Portillo, Sebastián

doi:10.36104/amc.2013.54

Cited by 11 publications

(1 citation statement)

References 21 publications

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“…To date, a limited number of studies has examined HEV disease burden in Colombian adults. Molecular and/or serological evidence of HEV infection has been detected in human sera or feces samples from acute hepatitis patients from different Colombian cities ( 27 , 28 ), blood donors from Antioquia ( 29 ), swine farm workers from Medellin ( 30 ), and in slaughtered pigs or pig feces in Antioquia ( 31 ) or Medellin ( 32 ), respectively. HEV genome was also detected in both waste and drinking water in Antioquia ( 33 ).…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of Hepatitis E virus in children and adolescents living in urban Bogotá: An explorative cross-sectional study

Villalobos

Kessel

Páez

et al. 2023

Front. Public Health

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The majority of Hepatitis E Virus (HEV)-related studies are carried out in adults whereas information about HEV seroprevalence, clinical disease manifestation, molecular epidemiology, and transmission patterns in children is limited. To estimate HEV seroprevalence among scholar children living in an urban setting and to analyze risk factors for an infection, we invited children aged 5–18 years from Bogotá (Colombia) for a cross-sectional survey. We collected self-reported data on demographics, social, clinical, and exposure variables in a structured interview. Venous blood samples were analyzed with two commercially available ELISAs for HEV-specific IgG antibodies. Among the 263 participants, we found three HEV IgG-reactive samples (1.1%) using both assays. We additionally characterized the samples for HEV IgM using a commercially available IgM ELISA and for HEV RNA. Here, we found one IgM-reactive sample, which was also reactive for IgG. In contrast, none of the IgM- and IgG-reactive sera samples showed detectable RNA levels indicating HEV exposure had not been recently. All participants reported access to drinking water and sanitary systems in their households and frequent hand washing routines (76–88%). Eighty percent of children reported no direct contact with pigs, but occasional pork consumption was common (90%). In contrast to the majority of studies performed in Colombian adults, we found a low unadjusted HEV seroprevalence of 1.1% (95% CI: 0.3–3.6%) for both HEV IgG ELISAs in our study population. While the majority of participants reported pork consumption, we speculate in the absence of viral RNA for genotyping in the affected individuals, that existing access to drinking water and sanitary systems within our study group contribute to the low HEV seroprevalence.

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Section: Introductionmentioning

confidence: 99%

Seroprevalence of Hepatitis E virus in children and adolescents living in urban Bogotá: An explorative cross-sectional study

Villalobos

Kessel

Páez

et al. 2023

Front. Public Health

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Phylogenetic analysis of Hepatitis E virus strains isolated from slaughter-age pigs in Colombia

Forero

Gutiérrez-Vergara

Suescún

et al. 2017

Infection, Genetics and Evolution

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Hepatitis E virus in South America: The current scenario

Pisano

Martinez‐Wassaf²,

Mirazo

et al. 2018

Liver International

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Hepatitis E virus (HEV) is one of the most frequent causes of acute viral hepatitis of enteric transmission worldwide. In South America the overall epidemiology has been little studied, and the burden of the disease remains largely unknown. A research of all scientific articles about HEV circulation in South America until November 2017 was carried out. Human seroprevalences of HEV varied according to the studied population: blood donors presented prevalence rates ranging from 1.8% to 9.8%, while reports from HIV‐infected individuals, transplant recipients and patients on hemodialysis showed higher prevalence rates. Only 2 cases of chronic hepatitis in solid‐organ transplant patients from Argentina and Brazil have been described. Detection of HEV in the swine population is widely prevalent in the region. Anti‐HEV antibodies have also been recently documented in wild boars from Uruguay. Although scarce, studies focused on environmental and food HEV detection have shown viral presence in these kind of samples, highlighting possible transmission sources of HEV in the continent. HEV genotype 3 was the most frequently detected in the region, with HEV genotype 1 detected only in Venezuela and Uruguay. HEV is widely distributed throughout South America, producing sporadic cases of acute hepatitis, but as a possible agent of chronic hepatitis. Finding the virus in humans, animals, environmental samples and food, show that it can be transmitted through many sources, alerting local governments and health systems to improve diagnosis and for the implementation of preventive measures.

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Seroprevalencia De Hepatitis E en Trabajadores de Fincas Porcícolas del Valle de Aburrá 2011-2012

Cited by 11 publications

References 21 publications

Seroprevalence of Hepatitis E virus in children and adolescents living in urban Bogotá: An explorative cross-sectional study

Seroprevalence of Hepatitis E virus in children and adolescents living in urban Bogotá: An explorative cross-sectional study

Phylogenetic analysis of Hepatitis E virus strains isolated from slaughter-age pigs in Colombia

Hepatitis E virus in South America: The current scenario

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