Seroprevalence of Zika Virus among Forest Fringe Communities in Peninsular Malaysia and Sabah: General Population-Based Study

Khoo, Hooi-Yuen; Lee, Hai Yen; Khor, Chee‐Sieng; Tan, Kian Lam; Hassan, Mohd Rohaizat; Wong, Chin Mun; Agustar, Hani Kartini; Samsusah, Nadia Aqilla; Rahim, Syed Sharizman Syed Abdul; Jeffree, Mohammad Saffree; Yusof, Nur Athirah; Haron, Noor Ain; Amin, Zarina; Hod, Rozita; AbuBakar, Sazaly

doi:10.4269/ajtmh.21-0988

Cited by 3 publications

(1 citation statement)

References 53 publications

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“…The low seropositivity does not agree with the high-level pre-existing immunity in the community theory. This study is also in line with the finding of other studies in Malaysia that show low seroprevalence rates of Zika virus (4,12,13). On the other hand, a study conducted in a neighboring state, Sabah, had shown an increased in the incidence of ZIKV infection (14).…”

Section: Resultssupporting

confidence: 91%

Detection of Zika Virus Antibodies in Retrospective Serum Samples from Suspected Dengue Cases in Sarawak, Malaysian Borneo

Alfie,

Henry Sum

2024

MJMHS

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Sarawak, a state in Malaysian Borneo, has never reported a case of Zika virus (ZIKV) infection nor conducted any seroprevalence studies on the virus. This study aimed to provide a serological insight into ZIKV in Sarawak. 212 sera samples collected from a dengue surveillance study conducted from 2007 to 2011 were retrospectively analyzed. Samples negative for both dengue and Japanese encephalitis virus by RT-PCR were screened by immunoblots assay for ZIKV prM protein. Positive samples were further subjected to 50% plaque reduction neutralization test (PRNT50) for confirmation. 20 (9.4%) sera samples were positive for ZIKV prM protein but not against prM of dengue and Japanese encephalitis virus. These 20 samples were further subjected to PRNT50, and six samples (2.8%) showed possible seropositivity for ZIKV. This preliminary investigation provides serological evidence of ZIKV infection in Sarawak and highlights the importance of conducting surveillance programs for ZIKV in this dengue-endemic state.

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Section: Resultssupporting

confidence: 91%

Detection of Zika Virus Antibodies in Retrospective Serum Samples from Suspected Dengue Cases in Sarawak, Malaysian Borneo

Alfie,

Henry Sum

2024

MJMHS

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Global seroprevalence of Zika virus in asymptomatic individuals: A systematic review

Saba Villarroel,

Hamel,

Gumpangseth

et al. 2024

PLoS Negl Trop Dis

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Background Zika virus (ZIKV) has spread to five of the six World Health Organization (WHO) regions. Given the substantial number of asymptomatic infections and clinical presentations resembling those of other arboviruses, estimating the true burden of ZIKV infections is both challenging and essential. Therefore, we conducted a systematic review and meta-analysis of seroprevalence studies of ZIKV IgG in asymptomatic population to estimate its global impact and distribution. Methodology/Principal findings We conducted extensive searches and compiled a collection of articles published from Jan/01/2000, to Jul/31/2023, from Embase, Pubmed, SciELO, and Scopus databases. The random effects model was used to pool prevalences, reported with their 95% confidence interval (CI), a tool to assess the risk of study bias in prevalence studies, and the I2 method for heterogeneity (PROSPERO registration No. CRD42023442227). Eighty-four studies from 49 countries/territories, with a diversity of study designs and serological tests were included. The global seroprevalence of ZIKV was 21.0% (95%CI 16.1%-26.4%). Evidence of IgG antibodies was identified in all WHO regions, except for Europe. Seroprevalence correlated with the epidemics in the Americas (39.9%, 95%CI:30.0–49.9), and in some Western Pacific countries (15.6%, 95%CI:8.2–24.9), as well as with recent and past circulation in Southeast Asia (22.8%, 95%CI:16.5–29.7), particularly in Thailand. Additionally, sustained low circulation was observed in Africa (8.4%, 95%CI:4.8–12.9), except for Gabon (43.7%), and Burkina Faso (22.8%). Although no autochthonous transmission was identified in the Eastern Mediterranean, a seroprevalence of 16.0% was recorded. Conclusions/Significance The study highlights the high heterogeneity and gaps in the distribution of seroprevalence. The implementation of standardized protocols and the development of tests with high specificity are essential for ensuring a valid comparison between studies. Equally crucial are vector surveillance and control methods to reduce the risk of emerging and re-emerging ZIKV outbreaks, whether caused by Ae. aegypti or Ae. albopictus or by the Asian or African ZIKV.

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The prevalence of IGM antibodies to Zika virus in pregnant women in Northern Nigeria

Adekola

Ojo

Balogun

et al. 2023

Problems of Virology

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Introduction. Zika virus (ZIKV) infection during pregnancy can result in severe outcomes for both the pregnant woman and the developing fetus. The objective of this study was to investigate the prevalence of Zika virus infection among pregnant women who sought healthcare services at Ahmadu Bello University Teaching Hospital. Materials and methods. Serum samples were collected and analyzed using Enzyme Linked Immunoassay and RT-qPCR methods, while a structured questionnaire was used to gather relevant information about the participants. Results. The results showed that 53 out of the 180 pregnant women tested positive for Anti-Zika IgM antibodies, which represents a 29.4% prevalence rate. Subsequent RT-qPCR analysis found that only 6 out of the 53 positive samples contained Zika virus RNA. Fever and headache were the most commonly reported symptoms related to the infection. Conclusion. These findings indicate a potential outbreak of Zika fever in Northern Nigeria emphasizing the importance for pregnant women to take precautions to avoid getting infected.

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Seroprevalence of Zika Virus among Forest Fringe Communities in Peninsular Malaysia and Sabah: General Population-Based Study

Cited by 3 publications

References 53 publications

Detection of Zika Virus Antibodies in Retrospective Serum Samples from Suspected Dengue Cases in Sarawak, Malaysian Borneo

Detection of Zika Virus Antibodies in Retrospective Serum Samples from Suspected Dengue Cases in Sarawak, Malaysian Borneo

Global seroprevalence of Zika virus in asymptomatic individuals: A systematic review

The prevalence of IGM antibodies to Zika virus in pregnant women in Northern Nigeria

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