Seroprevalence of varicella-zoster virus in the German population

Wutzler, Peter; Färber, I; Wagenpfeil, Stefan; Bisanz, Helmtrud; Tischer, Annedore

doi:10.1016/s0264-410x(01)00276-6

Cited by 143 publications

(115 citation statements)

References 21 publications

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“…This highly contagious disease is transmitted through airborne droplets, or as a smear infection through chickenpox blisters [5]. Varicella-zoster virus seroprevalence in Germany was very high before the general varicella vaccination recommendation was issued in 2004: over 95% of people 14 years of age and older exhibited IgG antibodies to VZV [6,7].…”

Section: Aetiologymentioning

confidence: 99%

Background paper to the decision not to recommend a standard vaccination with the live attenuated herpes zoster vaccine for the elderly in Germany

2017

Bundesgesundheitsbl

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Section: Aetiologymentioning

confidence: 99%

Background paper to the decision not to recommend a standard vaccination with the live attenuated herpes zoster vaccine for the elderly in Germany

2017

Bundesgesundheitsbl

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“…Plaques 1 to 2mm in diameter may be counted easily after an Incubation period of when cytotoxic effect is not usually detectable by microscopic observation, but V-Z infected Cell foci are darkly stained by the IP technique (7). The staining specificity of V-Z infected cells has been demonstrated by the disappearance of both nuclear and cytoplasmic staining absorption of specific V-Z immune serum with V-Z infected cells AND by the lack of cross reactions with human CMV and HSV when V-Z positive serum and conjugate were used at appropriate dilutions (9).The correlation between V-Zneutralising antibody needs to be established.The main advantage of IP plaque assay over classical V-Z virus plaque assays is that of obtaining results earlier.Moreover, no solidifying is required.However,disadvantage of technique lies in the use of human serum, which must be selected to contain antibodies only to V-Z virus and not to any other human herpesvirus.Several data suggest that V-Z virus and HSV share cells common antigens (8).…”

Section: April 2017mentioning

confidence: 99%

Knowledge and awareness of varicella zoster among the dental students

M.P¹

2017

Int j curr adv res

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“…Varicella is a ubiquitous disease: In countries with a temperate climate such as North America, European countries, more than 90% of the population contract the infection before the age of 15 years [54,[88][89][90][91][92][93] . It mainly affects children with especially winter/spring seasonality: It is estimated that 52%-78% of all reported cases of varicella occur in children aged < 6 years, and 89%-96% of cases in children aged < 14 years; only 5%-7% of cases occur in adults [5,94,95] .…”

Section: Epidemiologymentioning

confidence: 99%

Microbiology laboratory and the management of mother-child varicella-zoster virus infection

Paschale

Clerici

2016

WJV

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Varicella-zoster virus, which is responsible for varicella (chickenpox) and herpes zoster (shingles), is ubiquitous and causes an acute infection among children, especially those aged less than six years. As 90% of adults have had varicella in childhood, it is unusual to encounter an infected pregnant woman but, if the disease does appear, it can lead to complications for both the mother and fetus or newborn. The major maternal complications include pneumonia, which can lead to death if not treated. If the virus passes to the fetus, congenital varicella syndrome, neonatal varicella (particularly serious if maternal rash appears in the days immediately before or after childbirth) or herpes zoster in the early years of life may occur depending on the time of infection. A Microbiology laboratory can help in the diagnosis and management of mother-child infection at four main times: (1) when a pregnant woman has been exposed to varicella or herpes zoster, a prompt search for specific antibodies can determine whether she is susceptible to, or protected against infection; (2) when a pregnant woman develops clinical symptoms consistent with varicella, the diagnosis is usually clinical, but a laboratory can be crucial if the symptoms are doubtful or otherwise unclear (atypical patterns in immunocompromised subjects, patients with post-vaccination varicella, or subjects who have received immunoglobulins), or if there is a need for a differential diagnosis between varicella and other types of dermatoses with vesicle formation; (3) when a prenatal diagnosis of uterine infection is required in order to detect cases of congenital varicella syndrome after the onset of varicella in the mother; and (4) when the baby is born and it is necessary to confirm a diagnosis of varicella (and its complications), make a differential diagnosis between varicella and other diseases with similar symptoms, or confirm a causal relationship between maternal varicella and malformations in a newborn. Core tip: Although varicella during pregnancy is infrequent and congenital varicella syndrome (CVS) is rare, every available means should be used to prevent and diagnose them. Microbiology laboratories can be crucial in these situations: Evaluating a mother's immune status with sensitive and specific tests for the detection of antibodies; allowing a rapid diagnosis with molecular biology tests when a clinical manifestation may be due to different etiologies; following pregnant women with varicella for the prenatal diagnosis of CVS with close collaboration between molecular biology investigators and specialists in imaging diagnostics.De Paschale M, Clerici P. Microbiology laboratory and the management of mother-child varicella-zoster virus infection. World

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Seroprevalence of varicella-zoster virus in the German population

Cited by 143 publications

References 21 publications

Background paper to the decision not to recommend a standard vaccination with the live attenuated herpes zoster vaccine for the elderly in Germany

Background paper to the decision not to recommend a standard vaccination with the live attenuated herpes zoster vaccine for the elderly in Germany

Knowledge and awareness of varicella zoster among the dental students

Microbiology laboratory and the management of mother-child varicella-zoster virus infection

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