Seroprevalence of transfusion transmissible infections among blood donors in western part of Turkey: A six-year study

Uzun, Berrin; Güngör, Serdar; Demırcı, Mustafa

doi:10.1016/j.transci.2013.02.039

Cited by 20 publications

(27 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The overall prevalence for the TTIs over the 7 years is higher that reported from a study carried out over a 4 year period during same time in Ethiopia but lower than another study carried out in same town in Ethiopia over 5 years with larger population [17,18] . Higher rates have been reported from Mozambique and Ghana [19,20] while lower seroprevalence rate has been reported from Turkey where unlike aforementioned countries had a replacement blood donor of less than 30% [21]. Studies outside African consistently reported less overall seroprevalence irrespective of the duration of the studies [22,23] the infections showed significant inter-year variation.…”

Section: Discussionmentioning

confidence: 90%

A Seven Year Review of the Seroprevalence of Transfusion Transmitted Infections in a Hospital Based Blood Bank in Ibadan, Nigeria

Fasola¹

2017

CMR

View full text Add to dashboard Cite

Africa has the highest prevalence of transfusion transmitted infections. The World Health Organization recommends universal and quality-controlled screening of blood donations for the major transfusion-transmissible infections (TTIs): human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) and syphilis. Therefore a retrospective study was conducted to assess the effect of strategies in our blood bank to improve blood safety on the seroprevalence of HIV, HCV, HBV and syphilis infections among the donors over a seven year period. Existing data in the blood bank was used to determine number of the blood donors who were infected with HIV, HCV, HBV and syphilis. The test methods used to screen the donors were identified. The trend of prevalence of the transfusion transmitted infections among the blood donors from 2009 to 2015 was also determine. A total of 41,445 blood donors were screened. Voluntary blood donors constituted 11.1% of the donor population. The overall seroprevalence rate for the TTI was 12.3%. The prevalence was highest for HBV (8.5%) followed by HIV (1.8%), HCV (1.4%) and least for syphilis (0.5%) respectively. The infections showed significant inter-year variation (p<.001). A decreasing trend was observed for HBV among the blood donors while increase in prevalence of HIV, HCV and syphilis was observed from 2012 to 2014 and decreased in 2015. The prevalence of syphilis has risen from 0% in 2009 to 0.9% in 2015. The seroprevalence for TTI is high but is less compared to report from a previous study in same blood bank. The increasing infection rate for syphilis and sporadic surges in rates for HIV, HCV may suggest that the selection criteria is not effectively eliminating blood donors with risky lifestyle. There is need to educate the blood donors on avoiding risky lifestyle while also intensifying voluntary blood donor motivation strategy and increase community surveillance of the infections.

show abstract

Section: Discussionmentioning

confidence: 90%

A Seven Year Review of the Seroprevalence of Transfusion Transmitted Infections in a Hospital Based Blood Bank in Ibadan, Nigeria

Fasola¹

2017

CMR

View full text Add to dashboard Cite

show abstract

“…This is different in Western countries and in North Africa, where blood supply is mainly based on volunteer donation [15,37,38]. The trend of high male/female ratio has been reported in other studies in Cameroon [4,34,39] and elsewhere [37,[40][41][42]. This could be explained by physiological factors such as pregnancy, menstruation, and feeding which exclude some women from blood donation.…”

Section: Discussionmentioning

confidence: 91%

“…Indeed, despite the high blood transfusion needs in sub-Saharan Africa regions, and the increased awareness of its populations, family relatives or acquaintances remain the principal blood donors in the region [4,8,[34][35][36]. This is different in Western countries and in North Africa, where blood supply is mainly based on volunteer donation [15,37,38]. The trend of high male/female ratio has been reported in other studies in Cameroon [4,34,39] and elsewhere [37,[40][41][42].…”

Section: Discussionmentioning

confidence: 99%

Residual risk of transfusion-transmitted malaria infection in a malaria endemic sub-Saharan African setting

et al. 2017

View full text Add to dashboard Cite

Background: In Cameroon, as in many malaria endemic countries in Africa, blood donors are not routinely screened for Plasmodium infection that potentially could lead to severe malaria in some recipients. This study aimed at defining the prevalence of malaria among blood donors in Cameroon, and determining the risk of transfusion-transmitted malaria (TTM) following a single unit of blood transfusion. Methods: A total of 250 blood donors were recruited at the Douala General Hospital in Cameroon. Blood samples were tested for the presence of Plasmodium by using a rapid diagnostic test (RDT), and by thin and thick blood smear microscopy. A mathematical model was performed to calculate individual risk and to estimate population incidence rates of TTM per year. Different data sources were used in the sensitivity analysis prior to estimation of malaria transfusion risk. Results: More than half (96.8%) of all blood donors were men, and the mean age of the donors was 28.5 (SD = 8.9) years. Infected volunteer donors represented 2.80% while infected family-replacement donors comprised 97.20%. The prevalence of P. falciparum infection was 12.0%, and the population mean parasite density was 6,056 (95% CI: 4,542-8,076) parasites/μL. The individual median residual risk of TTM was 5.59 per 10,000 or 2.64 per 1,000 units of blood transfused every year in Douala or Cameroon, respectively. Conclusions: This study confirms the presence of P. falciparum as one of the most prevalent TTIs in the region. The residual risk of TTM is high among blood recipients, urging to conduct in malaria-endemic areas a cost-benefit analysis of systematically screening blood units for malaria parasites before transfusion versus systematically treating the recipient after transfusion.

show abstract

“…Another explanation is the greater number of first-time blood donors in mobile centers. TTIs are known to be more prevalent among firsttime blood donors (3,11). These findings highlight the necessity of quality public education in rural areas in order to have greater access to healthy blood products.…”

Section: Discussionmentioning

confidence: 99%

“…One of the most prevalent and life-threatening consequences of blood transfusion is transfusion-transmissible infections (TTIs), mainly immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV). HBV is the most common transfusion transmissible infection (3,10,11). Estimates show that there are around 350 million HBV carriers in the world (12).…”

Section: Introductionmentioning

confidence: 99%

Comparing the Prevalence of Hepatitis B Virus Infection in Stationary and Mobile Blood Donation Centers: A Cross-Sectional Descriptive Study

2017

View full text Add to dashboard Cite

Background and Aim: Blood transfusion can save a million lives. Nonetheless, every recipient is at risk for transfusiontransmissible infection, chiefly hepatitis B infection. The aim of this study was to compare stationary and mobile blood donation centers respecting the prevalence of hepatitis B in 2007 -2016. Methods: This cross-sectional descriptive study compared hepatitis B prevalence in stationary and mobile blood donation centers in Southern Khorasan in a ten-year period from 2007 to 2016. Data were retrieved from data sheets available from Iranian blood transfusion organization. Results: A total of 157063 blood units had been collected in 2007 -2016. The number of blood units collected by stationary and mobile centers was 129,899 (82.7%) and 27,164 (17.3%), respectively. Total hepatitis B prevalence rate was 0.22% (348 cases). This rate in stationary and mobile centers was 0.18% (232 cases) and 0.40% (116 cases), respectively. Hepatitis B prevalence was significantly greater in mobile centers than in stationary centers (P < 0.001). Moreover, hepatitis B prevalence in the second five years, i.e. 2012 -2016, was significantly lower than that in the first five years, i.e. 2007 -2011 (P < 0.001). Conclusions: Hepatitis B prevalence in mobile blood donation centers is significantly higher than that in stationary centers. This problem can be due to the limited health-related knowledge of blood donors in rural areas where mainly mobile centers collect blood units. Therefore, restricting blood collection by mobile centers may be indicated until necessary health-and donation-related educations are provided to all people in high-risk areas.

show abstract

Seroprevalence of transfusion transmissible infections among blood donors in western part of Turkey: A six-year study

Cited by 20 publications

References 8 publications

A Seven Year Review of the Seroprevalence of Transfusion Transmitted Infections in a Hospital Based Blood Bank in Ibadan, Nigeria

A Seven Year Review of the Seroprevalence of Transfusion Transmitted Infections in a Hospital Based Blood Bank in Ibadan, Nigeria

Residual risk of transfusion-transmitted malaria infection in a malaria endemic sub-Saharan African setting

Comparing the Prevalence of Hepatitis B Virus Infection in Stationary and Mobile Blood Donation Centers: A Cross-Sectional Descriptive Study

Contact Info

Product

Resources

About