Seroprevalence of toxoplasmosis in mentally retarded patients in Iranian rehabilitation centers

Ezatpour, Behrouz; Zibaie, Mohammad; Rahmati, Hessam; Pournia, Yadollah; Azami, Mehdi; Ebrahimzadeh, Farzad; Azadpour, Mojgan; Ghalesefidi, Maryam Jamshidian

doi:10.1007/s12639-013-0358-6

Cited by 11 publications

(7 citation statements)

References 19 publications

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“…T. gondii past infection was not found to be related to mental retardation in our study group, similar to results published by Ezatpour et al [43].…”

Section: Discussionsupporting

confidence: 93%

Toxoplasma gondii Infection in Patients with Psychiatric Disorders from Western Romania

et al. 2022

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Background and Objectives: High rates of infection with Toxoplasma gondii were found in psychiatric patients globally. In this study, we assessed for the first time the prevalence of T. gondii infection in psychiatric patients and healthy individuals with no known psychiatric disorders in Western Romania. Materials and Methods: The presence of specific IgG anti-T. gondii antibodies was evaluated in 308 psychiatric patients and 296 control subjects using a chemiluminescence assay. Results: Overall, the seroprevalence of IgG antibodies was higher in psychiatric patients (67.86%; 209/308), compared with the control group (54.05%; 160/296) (p < 0.001). Our results revealed a significantly higher prevalence of T. gondii antibodies among patients with schizophrenia (69.77%), organic (personality and behaviour) disorders (76.74%), and mental disorders concerning alcohol abuse (84.62%), compared with the control group (p = 0.009, p = 0.005, p = 0.043, respectively). Conclusions: This study provides new and important information on the seroprevalence of T. gondii in Romanian psychiatric patients and may serve for further scientific research regarding the status of T. gondii infection in patients with psychiatric disorders.

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“…T. gondii past infection was not found to be related to mental retardation in our study group, similar to results published by Ezatpour et al [43].…”

Section: Discussionsupporting

confidence: 93%

Toxoplasma gondii Infection in Patients with Psychiatric Disorders from Western Romania

et al. 2022

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“…The results of the present study indicate high prevalence of toxoplasmosis among residents of Isfahan city, central Iran, yet it is still lower than most of the other studied regions in the country (10)(11)(12)(13)(14)(15). Anti-Toxoplasma IgM seropositivity was observed in 2.8% of the studied subjects, which seems very low, but based on the fact that IgM mostly rises against the parasite in the acute phase of the infection (5), even 2.8% is considerable.…”

Section: Discussionmentioning

confidence: 52%

Anti-Toxoplasma IgM and IgG Seropositivity Among Individuals Referred to a Clinical Laboratory of Isfahan, Central Iran

Jafari¹,

Sadeghpour²,

Sharifi³

et al. 2016

Int J Infect

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Background: Toxoplasma gondii, a zoonotic parasite, is one of the wide spread parasitic causes of asymptomatic infection in human, yet can cause severe disease and disorders in infants, when infected during pregnancy, and also in immunocompromised individuals. Thus, updated information about the prevalence of the infection in each region and time period is necessary. Objectives: The aim of the present study was to determine the prevalence of the infection in patients referred to Dr. Sharifi clinical laboratory of Isfahan, Iran, during January 2014 to January 2015. Methods: In a retrospective study, 1287 patients that had anti-Toxoplasma IgM and/or IgG test from January 2013 to January 2015 were selected and included in the study. Quantitative determination of anti-Toxoplasma IgM and IgG was performed using antibody capture chemiluminescence immunoassay (CLIA) kits (LIAISON® Toxo IgM and IgG, DiaSorin S.P.A, Italy) applied using the LIAISON (DiaSorin, Germany) device. All the available variables such as anti-Toxoplasma IgG and IgM concentrations, gender and age were recorded and analyzed. Results: Overall, 1287 cases including 1215 (94.4%) females and 72 (5.6%) males with mean age of 28.64 years (min: 1, max: 78) were studied. The results showed that 36 (2.8%) out of 888 and 325 (25.3%) out of 1243 studied individuals were anti-Toxoplasma IgM and IgG seropositive, respectively. The mean age observed significantly higher in IgG positive humans (P < 0.001), but not in IgM positive ones (P = 0.065). No statistically significant relationship was observed for the IgM and IgG seropositivity and concentrations among the genders. Conclusions: According to the results of the present study, prevalence of infection with T. gondii is high in Isfahan, yet it is still lower than most of the other studied regions in the country. Also, the risk of the infection rises with increasing age.

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“…In a similar study, Sharif et al, (19) showed that among 336 sera tested by IFAT, 77.4% proved to be seropositive. In a more recent report also from Iran Ezatpour et al, (20) recorded seroprevalence of anti-T. gondii antibodies of 30.4% among 158 MR children in a rehabilitation center.…”

Section: Resultsmentioning

confidence: 93%

Seroprevalence of Toxoplasma gondii infection in mentally retarded children in Egypt

Hamed

El-Gebaly

megeid

et al. 2018

Parasitologists United Journal

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Background: Toxoplasmosis is one of the most common causes of latent infections in humans and animals. Its important clinical aspect is the probable danger of congenital transmission and its severe effects on the fetus. Infection is typically asymptomatic at birth, or is associated with serious neurological or ocular sequelae later in life with a broad spectrum of clinical presentations. Serologic screening detects acute infection in pregnant women which if unrecognized may be transmitted to the unborn. Objective: To investigate serologically the prevalence of toxoplasmosis as a hidden cause of mental retardation (MR) in a sample of children from urban and surrounding rural areas attending the New Children Hospital of Cairo University (Abu Reesh Hospital), Cairo. Material and Methods: The present study was conducted on 200 children diagnosed as MR attending neurology outpatient clinics as a case group; and 200 samples as a control group from non-MR children attending other outpatient clinics with minor complaints such as skin manifestations in dermatology clinic, upper respiratory infections and minor gastrointestinal complaints. Venous blood samples from the two groups of children were serologically tested for specific IgG by indirect hemagglutination test (IHAT). Relevant sociodemographic and clinical data related to the children and their mothers was collected using a designed sheet. Results: Our results showed that the prevalence of toxoplasmosis in the MR children was significantly positive in 84/200 (42.0%) of the case group (P <0.001). The number of positive sera was 35/200 (17.5%) among control group. Associated clinical manifestations in the case group (MR) included convulsions in 53.5%, eye problems in 22.5%, splenomegaly in 16.5% and hepatomegaly in 9.5% of cases. There was no significant difference between urban and rural residences; and relevant risk factors in mothers included history of previous toxoplasmosis (13.5%), history of abortion and still birth (each 36.5%) and premature deliveries (19.5%). History of contact with cats and consumption of undercooked meat rated 58% and 77.7% respectively. Conclusion: Screening females who are at risk for acquired toxoplasmosis is essential, before and during pregnancy to detect Toxoplasma seroconversion. Conversion from negative to positive testing would indicate exposure to infection, requiring the implementation of early treatment of infection to protect the unborn fetuses from transplacental transmission.

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Seroprevalence of toxoplasmosis in mentally retarded patients in Iranian rehabilitation centers

Cited by 11 publications

References 19 publications

Toxoplasma gondii Infection in Patients with Psychiatric Disorders from Western Romania

Toxoplasma gondii Infection in Patients with Psychiatric Disorders from Western Romania

Anti-Toxoplasma IgM and IgG Seropositivity Among Individuals Referred to a Clinical Laboratory of Isfahan, Central Iran

Seroprevalence of Toxoplasma gondii infection in mentally retarded children in Egypt

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