Seroprevalence of Toxocara Canis In Asthmatic Children and its Relation to the Severity of Diseases

Momen, Tooba; Esmaeil, Nafiseh; Reisi, Mohsen

doi:10.5455/medarh.2018.72.174-177

Cited by 11 publications

(10 citation statements)

References 20 publications

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“…In contrast to our study, several studies have reported a statistically significant difference between the seroprevalence of Toxocara infection among asthmatic and healthy children ( 6 , 10 , 11 ). Cobzaru et al ( 8 ) reported toxocariasis in asthma patients and control group 68.42% and 13.63%, respectively, and this difference was significant.…”

Section: Discussioncontrasting

confidence: 99%

“…The findings of our study regarding the seroprevalence of toxocariasis in asthmatic and healthy children were consistent with the results of several studies where no significant difference in Toxocara seropositivity was observed between the two groups ( 11 , 14 – 16 , 19 ). In a study ( 18 ), the seroprevalence of toxocariasis was higher in asthmatic children as compared to the healthy control, but there was no statistically significant association between seropositivity to Toxocara and risk of asthma in children.…”

Section: Discussionsupporting

confidence: 92%

“…In Isfahan, central of Iran, the seroprevalence of toxocariasis was 45% in the asthmatics group and 21.7% in the control group ( 11 ). In another studies, anti- Toxocara antibodies were detected in the serum samples of asthmatic children, while no antibodies against Toxocara were detected in the control group ( 17 , 20 ).…”

Section: Discussionmentioning

confidence: 99%

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Seroprevalence of Toxocara Infection among Asthmatic Children in Shiraz City, Southern Iran

Salemi¹,

Arefkhah²,

Mikaeili³

et al. 2021

IJPA

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Background: Human toxocariasis is caused by Toxocara canis and T. cati, the nematodes in the intestine of dogs and cats, respectively. Since the association between asthma and toxocariasis is controversial, the aim of the present study was to investigate the seroprevalence of Toxocara infection among asthmatic children in comparison with healthy children. Methods: This case-control study was conducted on 92 asthmatic and 91 healthy children aged 1-16 years old in Shiraz City, Southern Iran in 2019-2020. The serum samples were tested for IgG anti-Toxocara antibodies by ELISA method using the T. canis larval excretory-secretory (E/S) antigens. The collected data were analyzed using SPSS software. Results: The seroprevalence of toxocariasis in asthmatic patients was higher than the healthy children with no significant difference in Toxocara seropositivity between two groups (9.8% vs 8.8%, P = 0.817). The association between Toxocara infection and variables such as gender and age were not statistically significant. Conclusion: There was no significant association between toxocariasis and childhood asthma. Further study on different regions such as urban and rural areas with a large sample size and using questionnaire for considering risk factors of asthma and toxocariasis is recommended.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 92%

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Seroprevalence of Toxocara Infection among Asthmatic Children in Shiraz City, Southern Iran

Salemi¹,

Arefkhah²,

Mikaeili³

et al. 2021

IJPA

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“…Also, in a cross-sectional study, the odds ratio of toxocariasis was 1.73% in asthmatic children (15). Recently, in a case-control study in central Iran, the seroprevalence of Toxocara antibodies was 45% in asthmatic patients and 21.7% in controls (P = 0.02) (16).…”

Section: Discussionmentioning

confidence: 94%

Frequency of Toxocariasis Among Asthmatic Children in Northeastern Iran

Shamsian

Sayedi

Zibaei

et al. 2019

Arch Clin Infect Dis

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Background: Toxocariasis is a zoonotic and telluric disease caused by the Toxocara species mostly in tropical areas. The relationship between toxocariasis and asthma has always been a subject of discussion. Objectives: This study evaluated the seroepidemiology of Toxocara among asthmatic children. Methods: This cross-sectional study evaluated 150 children aged 3 -12 years with asthma presentations, who were referred to Dr. Sheikh Hospital of Mashhad University of Medical Sciences from April 2017 to March 2018. Serum samples were tested for the presence of anti-Toxocara antibodies using Enzyme-linked Immunosorbent assay (ELISA). Positive sera were confirmed by the Western Blotting (WB) method. Results: Out of 150 asthmatic patients, Toxocara immunoglobulin G (IgG) antibody responses were observed in two (1.3%) patients by ELISA and one (0.6%) patient by both ELISA and WB. Moreover, none of the patients was detected as hypereosinophilia. Conclusions: It seems there is no significant relationship between Toxocara infection and asthma in Northeastern Iran. These findings suggest the need for WB immunodiagnosis and ELISA using Toxocara antigens to improve human toxocariasis diagnosis in patients with asthma.

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“…The pulmonary toxo-cariasis was with asthma like symptoms [12] . The plausible role of parasitic infections as a trigger or a cause of asthma is not well investigated [13] . However, toxocariasis has been proposed as a probable etiology of asthma [14][15] .…”

Section: Introductionmentioning

confidence: 99%

Toxocariasis; A Neglected Tropical Disease, Association With Asthma, Chronic Urticaria and Unexplained Neurologic Manifestations Among Children

Temsah

Mostafa

El-Khaleegy

et al. 2020

International Journal of Medical Arts

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Background: The link between parasitic infections and either allergic diseases or unexplained neurologic manifestations was hypothesized especially in children. However, the debate continues regarding this link. Aim of the work: To determine the seroprevalence of toxocariasis in children with different allergic diseases [bronchial asthma and skin allergy], besides the unexplained neurological manifestations [epilepsy and focal neurologic deficits] in children. Patients and methods: Children with bronchial asthma [40 children], skin allergy [40 children], and unexplained neurological manifestations [epilepsy and focal neurologic deficits], [40 children] were included. All underwent a full history taking, clinical examination, lab investigations and determination of seropositivity for Toxocara canis. Results: Eosinophilia was reported in 22.5%, 30.0% and 17.5% of asthma, skin and unexplained neurological manifestations groups respectively. In patients with asthma, the prevalence of toxocariasis was 15.0%, in skin disease, the incidence was 7.5% and in unexplained neurological manifestations, it was 12.5%. There was no significant difference between positive and negative toxocariasis in regard to patient demographics. But there was a significant increase in contact with pets, chronic urticaria, lymph nodes involvement and eosinophilia in positive when compared to negative groups. Conclusion: The association between Toxocara canis infection and allergic diseases such as bronchial asthma, chronic urticaria and unexplained neurological manifestations [epilepsy and focal neurologic deficits], was confirmed in the present work. The contact with dogs and cats [pets] was the major determinant risk factor explaining such association. Prospective cohort studies were warranted to examine the cause effect relationship.

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Seroprevalence of Toxocara Canis In Asthmatic Children and its Relation to the Severity of Diseases

Cited by 11 publications

References 20 publications

Seroprevalence of Toxocara Infection among Asthmatic Children in Shiraz City, Southern Iran

Seroprevalence of Toxocara Infection among Asthmatic Children in Shiraz City, Southern Iran

Frequency of Toxocariasis Among Asthmatic Children in Northeastern Iran

Toxocariasis; A Neglected Tropical Disease, Association With Asthma, Chronic Urticaria and Unexplained Neurologic Manifestations Among Children

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