Seroprevalence of Subclinical HEV Infection in Healthy Pregnant Urban Dwellers of Bangladesh: Identification of Possible Risk Factors

Sultana, Gazi Zakia; Moniruzzaman, Mohammad; Mannan, Tania; Sultana, Rosy

doi:10.3329/jemc.v8i2.36731

Cited by 2 publications

(4 citation statements)

References 14 publications

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“…Previous studies have reported that HEV IgG seropositivity was more common in women who did not complete their higher secondary level of education. 14 Our study found that 20% positivity in people who have not completed higher secondary which is little higher (14.6%) than those who have done graduation and post graduation. Study by Bigna et al, from Cameroon, reported seroprevalence of 3.5% in asymptomatic pregnant women.…”

Section: Discussionmentioning

confidence: 44%

“…Higher seroprevalence of anti-HEV IgG (57.4%) was observed among pregnant women of lower middle class compared to the upper middle class (15.1%) by Sultana, G et al from Bangladesh. 14 Higher prevalence was associated with low socioeconomic status, which is considered as one of the risk factors. 13 Educational status has no significance observed in our study.…”

Section: Discussionmentioning

confidence: 99%

“…It was reported that prevalence rate is more among pregnant women in third trimester than first and second trimester. 14 The reason for these variation in prevalence rate as reported from various part of country could be due to early childhood HEV exposures producing long lasting immunity. Positivity also noted in close contacts of patients in some studies.…”

Section: Also Majority Of Participants Use Open Sanitationmentioning

confidence: 99%

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Seroprevalence of Hepatitis E Antibodies in Asymptomatic Antenatal Women from Tertiary Care Centre, Puducherry

Riyaz¹,

Umadevi²,

S³

et al. 2023

J. Pure Appl. Microbiol.

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Hepatitis E virus (HEV) is the most common cause of AVH in developing countries. HEV causes a self-limiting infection that is transmitted mainly through the consumption of contaminated food and water. Our study aimed to find out the seroprevalence of HEV infection. Detected both IgG & IgM antibodies from 100 asymptomatic antenatal women. ELISA (DIA PRO, Italy) was used to detect antibodies. Seropositivity was found in 9% of pregnant women, all might have been exposed to HEV infection previously. It could be unnoticed due to its self-limiting nature. IgG was 5% and IgM was 6%. Both IgM & IgG were detected in two pregnant women. Untreated water was used by the majority of women irrespective of their educational status. Though it is a self-limiting disease, it is necessary to screen for its antibody. Awareness about the modes of transmission & complications needs to be addressed in the community. It is necessary to do further studies for screening for HEV infection as there is a very limited number of studies published from South India.

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Section: Discussionmentioning

confidence: 44%

Section: Discussionmentioning

confidence: 99%

Section: Also Majority Of Participants Use Open Sanitationmentioning

confidence: 99%

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Seroprevalence of Hepatitis E Antibodies in Asymptomatic Antenatal Women from Tertiary Care Centre, Puducherry

Riyaz¹,

Umadevi²,

S³

et al. 2023

J. Pure Appl. Microbiol.

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“…[18][19] Reports from Bangladeshi pregnant women indicated similar higher patterns with 37.6% HEV IgG seropreprevalence. 20 The high prevalence of antibodies can be attributed to the sanitation conditions Alternatively, the predominant HEV genotypes in the developed countries could be less virulent than those in developing countries. The HEV genotypes circulating in endemic areas, including Pakistan, are mostly genotypes 1 and 2, which are very uncommon in industrialised countries.…”

Section: Discussionmentioning

confidence: 99%

Association of hepatitis E seropositivity and altered progesterone levels in pregnant women of low socioeconomic status from capital region of Pakistan

et al. 2020

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Abstract Objectives: To investigate the seroprevalence of hepatitis E virus infection, risk factors and its association with progesterone levels in pregnant women from low socioeconomic background. Methods: The cross-sectional study was conducted in Rawalpindi and Islamabad, Pakistan, from January to July 2012, and comprised pregnant asymptomatic healthy females from different clinics and hospitals of the twin cities. Data was collected using a predesigned demographic questionnaire to determine socioeconomic status. Prevalence of anti-hepatitis E virus antibodies and progesterone levels were determined using enzyme-linked immunosorbent assay kits. Results: Of the 90 women, 35(39%) were in the 21-25 year age group, and 55(61%) belonged to low socioeconomic background. The overall prevalence of seropositive hepatitis E virus immunoglobulin-G was 54(60%) and immunoglobulin-M was 12(13.3%). In the first trimester, the levels of progesterone were higher in patients positive for immunoglobulin-M compared to immunoglobulin-G (p<0.001). Conclusions: Low socioeconomic status appeared to be a potential risk factor associated with high hepatitis E virus seroprevalence and alterations in the normal progesterone levels during pregnancy. Key Words: Hepatitis E virus, HEV, Progesterone, Seroprevalence, Pakistan.

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Seroprevalence of Subclinical HEV Infection in Healthy Pregnant Urban Dwellers of Bangladesh: Identification of Possible Risk Factors

Cited by 2 publications

References 14 publications

Seroprevalence of Hepatitis E Antibodies in Asymptomatic Antenatal Women from Tertiary Care Centre, Puducherry

Seroprevalence of Hepatitis E Antibodies in Asymptomatic Antenatal Women from Tertiary Care Centre, Puducherry

Association of hepatitis E seropositivity and altered progesterone levels in pregnant women of low socioeconomic status from capital region of Pakistan

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