Seroprevalence of SARS-CoV-2 in German secondary schools from October 2020 to July 2021: a longitudinal study

Kirsten, Claudia; Kahre, Elisabeth; Blankenburg, Judith; Schumm, Leonie; Haag, Luise; Galow, Lukas; Unrath, Manja; Czyborra, Paula; Schneider, Josephine; Lück, Christian; Dalpke, Alexander H.; Berner, Reinhard; Armann, Jakob

doi:10.1007/s15010-022-01824-9

Cited by 7 publications

(5 citation statements)

References 29 publications

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“…Students from fourteen secondary schools in the metropolitan area of Dresden and surrounding rural Saxony, Germany, who already participated in the SchoolCoviDD19-study 29 with serial assessment of the SARS-CoV-2-serostatus, were invited to participate in the ImmunCoviDD19-study. The study was approved by the ethics committee of the Technical University of Dresden (BO-EK-265052021) and conducted according to the declaration of Helsinki.…”

Section: Methodsmentioning

confidence: 99%

“…Out of 121 participants, 49 participants were seronegative and 63 seropositive for SARS-CoV-2 IgG. Seropositivity against SARS-CoV-2 was defined as the presence of anti-S1 and anti-S2 specific IgG antibodies > 15.0 AU/ml to SARS-CoV-2 in Diasorin LIAISON® SARS-CoV-2 S1/S2 IgG Assay 29 . In addition, 9 participants reported a complete vaccination status (Fig.…”

Section: Methodsmentioning

confidence: 99%

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Increased red blood cell deformation in children and adolescents after SARS-CoV-2 infection

Eder

Schumm

Armann

et al. 2023

Sci Rep

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Severe coronavirus disease 2019 (COVID-19) is associated with hyperinflammation, hypercoagulability and hypoxia. Red blood cells (RBCs) play a key role in microcirculation and hypoxemia and are therefore of special interest in COVID-19 pathophysiology. While this novel disease has claimed the lives of many older patients, it often goes unnoticed or with mild symptoms in children. This study aimed to investigate morphological and mechanical characteristics of RBCs after SARS-CoV-2 infection in children and adolescents by real-time deformability-cytometry (RT-DC), to investigate the relationship between alterations of RBCs and clinical course of COVID-19. Full blood of 121 students from secondary schools in Saxony, Germany, was analyzed. SARS-CoV-2-serostatus was acquired at the same time. Median RBC deformation was significantly increased in SARS-CoV-2-seropositive compared to seronegative children and adolescents, but no difference could be detected when the infection dated back more than 6 months. Median RBC area was the same in seropositive and seronegative adolescents. Our findings of increased median RBC deformation in SARS-CoV-2 seropositive children and adolescents until 6 months post COVID-19 could potentially serve as a progression parameter in the clinical course of the disease with an increased RBC deformation pointing towards a mild course of COVID-19.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Increased red blood cell deformation in children and adolescents after SARS-CoV-2 infection

Eder

Schumm

Armann

et al. 2023

Sci Rep

Self Cite

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“…Between 18th January and 20th July 2021, 394 households were enrolled into the seroprevalence FamilyCoviDD19 study. Upon a positive SARS-CoV-2-PCR test, 254 households were enrolled whilst 46 were enrolled after positive antibody testing in our seroprevalence SchoolCoviDD19- and KiTaCoviDD19-study 37 , 38 . Eventually, 21 households were excluded because they did not meet the inclusion criteria (no other household member of the index person participated or household members did not have any contact during the infection period).…”

Section: Methodsmentioning

confidence: 99%

Lower SARS-CoV-2 household transmission in children and adolescents compared to adults

Schumm

Blankenburg

Kahre

et al. 2022

Sci Rep

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In the COVID-19 pandemic, children were considered to play a major role in SARS-CoV-2 transmission similar to influenza. Thus, mitigation measures have been focused on children, impacting their everyday life severely. Despite this, infectivity in this age group regarding SARS-CoV-2 is not yet clarified. We performed a serology study in households with confirmed SARS-CoV-2 infection to evaluate virus transmission with focus on children and adolescents. Between January and July 2021, 341 minors and 650 adults from 300 households with a confirmed index case participated in the FamilyCoviDD19-study including serological assessment for SARS-CoV-2 antibodies and a questionnaire on demographics, recent and ongoing symptoms, hygiene measures and comorbidities. 45 (16.3%) of all index cases were < 18 years old. Thereof, 55.6% reported COVID-19 associated symptoms, while nearly all adult index cases were symptomatic (94.8%). There was significantly less virus transmission by children and adolescents compared to adult index cases with a secondary attack rate of 0.29 vs. 0.54. With the caveat that the results do not necessarily apply to the Delta and Omicron variants, we conclude that children and adolescents are less susceptible for SARS-CoV-2 infection, more frequently show an asymptomatic course of disease and are less infective than adults.

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“…SARS-CoV-2 is highly stable in aerosol and on surfaces compared to SARS-CoV-1, maintaining the virus infectious for hours in the aerosol (Anfinrud et al, 2020;Morawska and Cao, 2020;Paules et al, 2020;van Doremalen et al, 2020;Ong et al, 2021). These facts imply that in the absence of face masks the distance of 1-2 m among people is not enough to safeguard from SARS-CoV-2 infection risk (Parshina-Kottas et al, 2020), as it has been reported to happen in hospitals (i.e., SARS-CoV-2 RNA has been detected in air samples collected inside the hospitals, thereby the airborne route has to be considered an important pathway for contamination), schools and other indoors spaces (Liu et al, 2020f;Nissen et al, 2020;Santarpia et al, 2020;Akhmetzhanov et al, 2021;Chau et al, 2021;Ding et al, 2021;Kumari et al, 2021;Leeman et al, 2022;Marchese et al, 2021;Miyoshi et al, 2021;Murewanhema et al, 2021;Ong et al, 2021;Salmenjoki et al, 2021;Sami et al, 2021;San et al, 2021;Jung et al, 2022;Kirsten et al, 2022;Ladhani et al, 2022;Leng et al, 2022;Nagy et al, 2022;Polechova et al, 2022;Viner et al, 2022;White et al, 2022). Therefore, SARS-CoV-2 is transmitted by bioaerosols (<10 μm) and droplets (>10 μm) projected during breathing, speaking and coughing (Klompas et al, 2020a;Binder et al, 2020;Liu et al, 2020f;Nissen et al, 2020;van Doremalen et al, 2020;Zhang and Duchaine, 2020;...…”

Section: Physical Barriers For Prevention: Face Masks and Protective ...mentioning

confidence: 99%

Nanomaterials to combat SARS-CoV-2: Strategies to prevent, diagnose and treat COVID-19

Valenzuela-Fernandez

Cabrera-Rodríguez

Ciuffreda

et al. 2022

Front. Bioeng. Biotechnol.

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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the associated coronavirus disease 2019 (COVID-19), which severely affect the respiratory system and several organs and tissues, and may lead to death, have shown how science can respond when challenged by a global emergency, offering as a response a myriad of rapid technological developments. Development of vaccines at lightning speed is one of them. SARS-CoV-2 outbreaks have stressed healthcare systems, questioning patients care by using standard non-adapted therapies and diagnostic tools. In this scenario, nanotechnology has offered new tools, techniques and opportunities for prevention, for rapid, accurate and sensitive diagnosis and treatment of COVID-19. In this review, we focus on the nanotechnological applications and nano-based materials (i.e., personal protective equipment) to combat SARS-CoV-2 transmission, infection, organ damage and for the development of new tools for virosurveillance, diagnose and immune protection by mRNA and other nano-based vaccines. All the nano-based developed tools have allowed a historical, unprecedented, real time epidemiological surveillance and diagnosis of SARS-CoV-2 infection, at community and international levels. The nano-based technology has help to predict and detect how this Sarbecovirus is mutating and the severity of the associated COVID-19 disease, thereby assisting the administration and public health services to make decisions and measures for preparedness against the emerging variants of SARS-CoV-2 and severe or lethal COVID-19.

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Seroprevalence of SARS-CoV-2 in German secondary schools from October 2020 to July 2021: a longitudinal study

Cited by 7 publications

References 29 publications

Increased red blood cell deformation in children and adolescents after SARS-CoV-2 infection

Increased red blood cell deformation in children and adolescents after SARS-CoV-2 infection

Lower SARS-CoV-2 household transmission in children and adolescents compared to adults

Nanomaterials to combat SARS-CoV-2: Strategies to prevent, diagnose and treat COVID-19

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