Seroprevalence of SARS Coronavirus Among Residents Near a Hospital with a Nosocomial Outbreak

Tsai, Ming Han; Lin, Tzou Yien; Chiu, Cheng Hsun; Lin, Pen Yi; Huang, Yhu Chering; Tsao, Kuo Chien; Huang, Chung Guei; Hsu, Kuang‐Hung; Lin, Meng C.; Hwang, Kao Pin; Yang, Kuender D.

doi:10.1016/s0929-6646(08)60205-3

Cited by 2 publications

(1 citation statement)

References 19 publications

(18 reference statements)

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“…38 Although most patients with SARS had symptomatic disease, there are few seroprevalence studies and one study showed that 124 (12%) of 1,030 individuals were positive by ELISA and 0.19% by the SARS-specific immunofluorescence assay (IFA). 39 In another study, seroprevalence among HCWs was 2.3% 40 and a meta-analysis showed an overall seroprevalence of 0.10%. 41 There were no approved therapeutic or preventative options for SARS, while a variety of therapeutic agents were used.…”

Section: Sars Outbreak Evolution and Clinical Characteristicsmentioning

confidence: 96%

Middle East Respiratory Syndrome Coronavirus and Severe Acute Respiratory Syndrome Coronavirus

Al‐Tawfiq

Memish

2020

Semin Respir Crit Care Med

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AbstractEmerging infectious diseases continue to be of a significant importance worldwide with the potential to cause major outbreaks and global pandemics. In 2002, the world had witnessed the appearance of the severe acute respiratory syndrome coronavirus in China which disappeared abruptly within 6 months. About a decade later, a new and emerging novel coronavirus named the Middle East respiratory syndrome coronavirus (MERS-CoV) was described in a patient from Saudi Arabia. These two coronaviruses shared multiple similarities in the epidemiology, clinical presentations, and posed challenges in its prevention and management. Seven years since its discovery, MERS-CoV continues to be a lethal zoonotic pathogen capable of causing severe pneumonia with high case fatality rates and the ability to cause large health care-associated outbreaks.

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Section: Sars Outbreak Evolution and Clinical Characteristicsmentioning

confidence: 96%

Middle East Respiratory Syndrome Coronavirus and Severe Acute Respiratory Syndrome Coronavirus

Al‐Tawfiq

Memish

2020

Semin Respir Crit Care Med

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Comparison of confirmed COVID‐19 with SARS and MERS cases ‐ Clinical characteristics, laboratory findings, radiographic signs and outcomes: A systematic review and meta‐analysis

Pormohammad

Ghorbani

Khatami

et al. 2020

Reviews in Medical Virology

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Introduction: Within this large-scale study, we compared clinical symptoms, laboratory findings, radiographic signs, and outcomes of COVID-19, SARS, and MERS to find unique features. Method:We searched all relevant literature published up to February 28, 2020.Depending on the heterogeneity test, we used either random or fixed-effect models to analyze the appropriateness of the pooled results. Study has been registered in the PROSPERO database (ID 176106).Result: Overall 114 articles included in this study; 52 251 COVID-19 confirmed patients (20 studies), 10 037 SARS (51 studies), and 8139 MERS patients (43 studies) were included. The most common symptom was fever; COVID-19 (85.6%, P < .001), SARS (96%, P < .001), and MERS (74%, P < .001), respectively. Analysis showed that 84% of Covid-19 patients, 86% of SARS patients, and 74.7% of MERS patients had an abnormal chest X-ray. The mortality rate in COVID-19 (5.6%, P < .001) was lower than SARS (13%, P < .001) and MERS (35%, P < .001) between all confirmed patients. Conclusions: At the time of submission, the mortality rate in COVID-19 confirmed cases is lower than in SARS-and MERS-infected patients. Clinical outcomes and findings would be biased by reporting only confirmed cases, and this should be considered when interpreting the data.

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Seroprevalence of SARS Coronavirus Among Residents Near a Hospital with a Nosocomial Outbreak

Abstract: There was low post-epidemic seroprevalence of SARS-CoV in a community adjacent to a hospital which had a nosocomial SARS outbreak. The SARS outbreak in Taiwan was primarily limited to hospital settings.

Cited by 2 publications

References 19 publications

Middle East Respiratory Syndrome Coronavirus and Severe Acute Respiratory Syndrome Coronavirus

Middle East Respiratory Syndrome Coronavirus and Severe Acute Respiratory Syndrome Coronavirus

Comparison of confirmed COVID‐19 with SARS and MERS cases ‐ Clinical characteristics, laboratory findings, radiographic signs and outcomes: A systematic review and meta‐analysis

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