Seroprevalence of Measles, Mumps, Rubella and Varicella Antibodies in the United States Population, 2009–2010

Lebo, Emmaculate; Kruszon-Moran, Deanna; Marin, Mona; Bellini, William J.; Schmid, Scott; Bialek, Stephanie R.; Wallace, Gregory S.; McLean, Huong Q.

doi:10.1093/ofid/ofv006

Cited by 62 publications

(55 citation statements)

References 12 publications

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“…The figures demonstrate considerable variability among studies that report results for different years, and even in some cases for the same or overlapping years. For example, for the United States, the National Health and Nutrition Examination Survey (NHANES) provided national data collected 1988–1994, 1999–2004, and a forthcoming study provides an update of measles serology based on 2009–2010 NHANES data, while the remaining U.S. studies in Table focus on specific states or cities. We selected the areas for Figs.…”

Section: Resultsmentioning

confidence: 99%

Systematic Review of Measles and Rubella Serology Studies

Thompson

Odahowski²

2015

Risk Analysis

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Serological tests provide information about individual immunity from historical infection or immunization. Cross-sectional serological studies provide data about the age- and sex-specific immunity levels for individuals in the studied population, and these data can provide a point of comparison for the results of transmission models. In the context of developing an integrated model for measles and rubella transmission, we reviewed the existing measles and rubella literature to identify the results of national serological studies that provided cross-sectional estimates of population immunity at the time of data collection. We systematically searched PubMed, the Science Citation Index, and references we identified from relevant articles published in English. We extracted serological data for comparison to transmission model outputs. For rubella, serological studies of women of child-bearing age provide information about the potential risks of infants born with congenital rubella syndrome. Serological studies also document the loss of maternal antibodies, which occurs at different rates for the different viruses and according to the nature of the induced immunity (i.e., infection or vaccine). The serological evidence remains limited for some areas, with studies from developed countries representing a disproportionate part of the evidence. The collection and review of serological evidence can help program managers identify immunity gaps in the population, which may help them better understand the characteristics of individuals within their populations who may participate in transmission and manage risks.

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Section: Resultsmentioning

confidence: 99%

Systematic Review of Measles and Rubella Serology Studies

Thompson

Odahowski²

2015

Risk Analysis

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“…We also examined if plasma from a high-titer center might also be enriched with other antiviral antibodies. Similar to HAV, MeV and CMV are viruses for which suitable antibody levels in IG products are clinically important 22,23 . When the full sets of plasma pools from El Paso-TX and Midwest City-OK were compared, there was no significant difference in anti-CMV IgG levels.…”

Section: Discussionmentioning

confidence: 99%

Plasma Donors in the Southwestern United States Positively Contribute to the Diverse Therapeutic Antibody Profile of Immune Globulin Products

Ciencewicki

Schouest

Gierman

et al. 2020

Sci Rep

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Human-plasma-derived immune globulin (iG) is used in augmentation therapy to provide protective levels of antibodies to patients with primary immune deficiency diseases (PIDD) and for prophylaxis against infectious diseases. To maintain the breadth of antibodies necessary for clinical protection, it is important to understand regional patterns of antibody seroprevalence in source plasma from which IG products are manufactured. In this study, source plasma from donation centers in various locations of the Southwestern quarter of the United States was surveyed for antibody titers to hepatitis A virus (HAV), measles virus (MeV), and cytomegalovirus (CMV). A broad range of anti-HAV Ig plasma titers was observed among these centers, with some centers exhibiting 3-5 times the titers of the others. Minor to no differences were observed for levels of anti-MeV and anti-CMV, respectively. Importantly, elevated anti-HAV Ig titers were broadly observed across plasma units obtained from the centers exhibiting high titers, indicative of a potential regional phenomenon among donors as opposed to few donors with singularly high titers. Plasma from these high-titer centers conferred significantly greater neutralization against HAV in vitro. The outcomes of this study give a glimpse of the antibody diversity inherent in human plasma used to manufacture IG products..

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“…Data from the 2009–2010 NHANES serological survey found that VZV seroprevalence was 97% for 12–19 and 98%-99% for 20–49 year-olds 16 . Nevertheless, there may be pockets of students susceptible to varicella on college campuses if they were never vaccinated and never had varicella disease, which is becoming increasingly likely given declining varicella incidence in the U.S. 22 In addition, the number of school-aged children with non-medical varicella vaccination exemptions is increasing 23 , potentially raising the number of un- or under-vaccinated young adults.…”

Section: Commentmentioning

confidence: 99%

“…These outbreaks can lead to disruption in school attendance and activities 6 ; students with varicella may miss classes and activities for 7 days or more 13 . Although a large proportion of US college-aged students are likely to have immunity against varicella, international students may have higher susceptibility to varicella, and students with underlying conditions who have contraindications for vaccination may be at greater risk for severe varicella 14–16 . ACIP recommends 2-doses of varicella vaccine or other evidence of immunity to varicella be required for college-entry since 2007 13 .…”

Section: Introductionmentioning

confidence: 99%

Varicella immunization requirements for US colleges: 2014–2015 academic year

Leung

Marin

Leino

et al. 2016

Journal of American College Health

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Objective To obtain information on varicella pre-matriculation requirements in US colleges for undergraduate students during the 2014–2015 academic year. Participants Healthcare professionals and member-schools of the American College Health Association (ACHA). Methods An electronic survey was sent to ACHA members regarding school characteristics and whether schools had policies in place requiring that students show proof of 2-doses of varicella vaccination for school attendance. Results Only 27% (101/370) of schools had a varicella pre-matriculation requirement for undergraduate students. Only 68% of schools always enforced this requirement. Private schools, 4-year schools, Northeastern schools, those with <5,000 students, and schools located in a state with a 2-dose varicella vaccine mandate were significantly more likely to have a varicella pre-matriculation requirement. Conclusions A small proportion of US colleges have a varicella pre-matriculation requirement for varicella immunity. College vaccination requirements are an important tool for controlling varicella in these settings.

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Seroprevalence of Measles, Mumps, Rubella and Varicella Antibodies in the United States Population, 2009–2010

Cited by 62 publications

References 12 publications

Systematic Review of Measles and Rubella Serology Studies

Systematic Review of Measles and Rubella Serology Studies

Plasma Donors in the Southwestern United States Positively Contribute to the Diverse Therapeutic Antibody Profile of Immune Globulin Products

Varicella immunization requirements for US colleges: 2014–2015 academic year

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