Seroprevalence of measles and rubella antibodies in pregnant women Haiti, 2012

Fitter, David; Anselme, Renette; Paluku, Gilson; Rey, Gloria; Flannery, Brendan; Tohme, Rania A.; Marston, Barbara J.; Griswold, Mark A.; Boncy, Jacques; Vertefeuille, John

doi:10.1016/j.vaccine.2013.10.071

Cited by 11 publications

(10 citation statements)

References 5 publications

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“…38 Moreover, infection of rubella virus leads to lifelong immunity. Similar trends of exposure to rubella were reported in Nigeria (87.5%), 39 Tanzania (92.9%), 40 Haiti (93.4%), 41 Turkey (93.8%), 42 and Croatia (94.6%) 31 ; however, our findings showed a higher prevalence to rubella than reported in Burkina Faso (77%) 43 and western Sudan (65.3%). 44 Exposure to CMV among pregnant women was also high in our study.…”

Section: Discussionsupporting

confidence: 87%

TORCH Antibodies Among Pregnant Women and Their Newborns Receiving Care at Kilimanjaro Christian Medical Centre, Moshi, Tanzania

Saajan

Nyindo

Gidabayda

et al. 2017

EAHRJ

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Background: Toxoplasmosis, other (syphilis, varicella-zoster, parvovirus B19, and hepatitis B), rubella, cytomegalovirus (CMV), and herpes simplex virus type 1 and type 2 (HSV-1 and HSV-2) -known by the acronym TORCHis a group of infections affecting both mothers and their unborn babies with adverse short-and long-term outcomes. The majority of infected mothers are asymptomatic, which leaves only speculation as to the probable cause of many congenital anomalies, stillbirths, prematurity, and death resulting from TORCH infections. The main objective of this study was to investigate previous exposure to TORCH infections by measuring the seroprevalence of TORCH antibodies in pregnant women and their newborns receiving care at Kilimanjaro Christian Medical Centre (KCMC), Moshi, Tanzania.Methods: This was a cross-sectional, hospital-based study conducted at KCMC from December 2013 to April 2014. Of 350 pregnant women enrolled in the study, we tested 347 pregnant women attending the antenatal clinic and who opted to deliver at KCMC. Cord blood was collected and analysed for 309 of their newborns. To identify immunoglobulin G (IgG) and immunoglobulin M (IgM) antibodies in mothers and IgM antibodies in newborns, we used enzyme-linked immunosorbent assay testing. A structured questionnaire was used to collect data of mothers and their newborns. Data analysis was done using SPSS version 20.Results: The seroprevalence of IgG antibodies to TORCH infections among pregnant women was 154 (44.4%) for toxoplasmosis, 311 (89.6%) for rubella, 343 (98.6%) for CMV, and 346 (99.7%) for HSV-1 and HSV-2; 141 (40.6%) had been exposed to all 4 infections. For HSV-1 and HSV-2, the IgM antibodies were found in 137 (39.5%) of the 347 pregnant women included in this study. Age above 35 years (OR 6.15; 95% CI, 1.22-31.1; P=.028) and multiparity (OR 1.63; 95% CI, 1.01-2.62; P=.045) were associated with higher risk of being exposed to all TORCH infections. A total of 11 newborns had IgM antibodies to HSV-1 and HSV-2 giving a seroprevalence of 3.6%, and one newborn had IgM antibodies to rubella, giving a seroprevalence of 0.3%. None of the newborns had antibodies to toxoplasmosis and CMV.Conclusions: Exposure to TORCH infections was high among pregnant women in our population. Older age and multiparity were associated with a higher risk of being exposed to all TORCH infections. Seroprevalence to HSV-1 and HSV-2 was high in newborns. The higher IgM antibodies to HSV-1 and HSV-2 among pregnant mothers and their newborns may disturb maternal, fetal, and neonatal health, and therefore we recommend establishing treatment protocol to support management of pregnant women and newborns who are seropositive for IgM antibodies.

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Section: Discussionsupporting

confidence: 87%

TORCH Antibodies Among Pregnant Women and Their Newborns Receiving Care at Kilimanjaro Christian Medical Centre, Moshi, Tanzania

Saajan

Nyindo

Gidabayda

et al. 2017

EAHRJ

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“…Adopting the cut off value of 10 IU/ml, our prevalence is comparable with the 85.8 and 87.5% seroprevalence reported in southern Italy [ 16 ] and Osogbo [ 23 ], respectively. However, it is lower than the prevalence recorded in Burkina Faso [ 17 ], Ontario [ 30 ], Haiti [ 18 ], and Jeddah [ 31 ] with seroprevalence of 93.3, 90, 92.8 and 91.6%, respectively.…”

Section: Discussionmentioning

confidence: 76%

Rubella seroprevalence among pregnant women in Beijing, China

Meng

Luo

et al. 2018

BMC Infect Dis

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BackgroundRubella infection in pregnant women can result in serious effects, such as miscarriages, stillbirths, and congenital rubella syndrome (CRS). However, very little is known about the rubella seroprevalence among pregnant women in China.MethodsThis is a cross-sectional and hospital-based study. From June 2016 through March 2017, a total of 324 serum samples from healthy pregnant women were collected in the Shunyi Women and Children’s Hospital of Beijing Children’s Hospital. Rubella-specific IgG antibody was determined by ELISA (Euroimmun, Lübeck, Germany) kits. International assigned cut-off values of ≥10 IU/ml were used to assess the percentage of pregnant women with protective IgG concentrations.ResultsThe total rate of protected individuals was 83.3% (95% CI: 78.9%–87.0%). The protective rates of pregnant women in 17–26 years group, 27–36 years group and 37–46 years group were 84.0% (95% CI: 75.3%–90.1%), 81.9% (95% CI: 74.9%–87.4%) and 84.9% (95% CI: 75.8%–90.9%) respectively. No significant difference in protective rates among the three age groups was found (P = 0.83). There were also no statistically significant correlations between protective rates and gravidity (P = 0.84), parity (P = 0.84), birth place (P = 0.16), residence area (P = 0.58), education (P = 0.40) or occupation (P = 0.65).ConclusionsDespite the generally low vaccination coverage for rubella, most of Chinese pregnant women had potent rubella immunity. However, at least 16.7% of pregnant women were susceptible to rubella, which suggested rubella immunization in Chinese women at or before child-bearing age.

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“…The rubella prevalence varies among different countries: 53% in Nigeria [6] , 76% in Sri Lanka [7] , 77.5% in Russia [8] , 94.1% in Spain [9] , 93.4% in Haiti [10] , 93% in Australia [11] , 89.1% in Taiwan [12] , 87% in Germany [13] , 72% in Sudan [14] , and 96% in Iran [15] . Studies investigating the prevalence of rubella in Turkey are listed in Table 4.…”

Section: Discussionmentioning

confidence: 99%

Seroprevalance of Rubella Antibodies Among Pregnant Women in a Regional Maternity Hospital in Eastern Turkey

Tanrıverdi¹,

Dikbaş²,

Alay³

et al. 2018

mjima

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Introduction: Rubella infection in pregnancy may cause severe complications, including still birth, miscarriage, preterm labor, growth deficiency, congenital malformation, blindness, cardiac defects, central nervous system abnormalities, and congenital cataract and hearing loss. The purpose of this study was to investigate the seroprevalence of rubella in pregnant women presenting to our hospital for routine antenatal examination, to compare our results with those from other countries, and to contribute to the literature by discussing opinions concerning rubella screening in pregnancy with data from 27.465 patients. Material and Methods: This retrospective study involved anti-rubella IgM and IgG screening results of pregnants in the first trimester, aged 17-45 and presented to our hospital for antenatal examination between 2013 and 2016. Data were collected from the hospital's electronic records system and patient files. Rubella antibody levels were determined using commercially available ELISA kits (ALISEI SEAC, Italy) in the medical microbiology laboratory. Anti-rubella IgM-positive cases were also evaluated using the avidity test. The results were analyzed using the SPSS v.15.0 (SPSS Inc., Chicago, Illinois, USA) data analysis system. Results: Rubella IgM antibody positivity was determined in 205 (0.8%) of 27.465 pregnants whose anti-rubella IgM status was investigated, and positive values were observed in 16.526 (9.2%) of 17.186 cases subjected to anti-rubella IgG antibody analysis. Anti-rubella avidity tests revealed high avidity in 92.7% of patients, low avidity in 3.4%, and intermediate avidity in 3.9%. Conclusion: We think that rubella screening during pregnancy is essential, and that the best means of reducing the adverse effects of rubella virus would be to provide full immunization before pregnancy for females of child-bearing age.

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Seroprevalence of measles and rubella antibodies in pregnant women Haiti, 2012

Cited by 11 publications

References 5 publications

TORCH Antibodies Among Pregnant Women and Their Newborns Receiving Care at Kilimanjaro Christian Medical Centre, Moshi, Tanzania

TORCH Antibodies Among Pregnant Women and Their Newborns Receiving Care at Kilimanjaro Christian Medical Centre, Moshi, Tanzania

Rubella seroprevalence among pregnant women in Beijing, China

Seroprevalance of Rubella Antibodies Among Pregnant Women in a Regional Maternity Hospital in Eastern Turkey

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