Seroprevalence of Leptospirosis in Working Dogs

Lau, Seng Fong; Khor, Kuan Hua; Roslan, Muhammad Azri; Rahman, Muhammad Sabri Abdul; Bejo, Siti Khairani; Radzi, Rozanaliza; Bahaman, Abdul Rani

doi:10.1053/j.tcam.2017.12.001

Cited by 23 publications

(33 citation statements)

References 33 publications

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“…The reason could likely be due to the speci c selection of recruited dogs and serum tested against 20 leptospiral serovars selected. In comparison, previous studies investigated a larger population of apparent healthy shelter and working dogs [19], some investigated healthy dogs from a single location [21,22] and one study was carried out among the pet dogs [23]. All these studies only aimed to determine seropositive among apparently healthy dogs using a panel of 10 leptospiral serovars, unlike in this study.…”

Section: Discussionmentioning

confidence: 97%

“…Therefore, incorporating known local leptospiral serovars is highly recommended in the diagnostic workout to improve detection rate as these serovars had shown to cause disease among dogs. Locally, both serovars Bataviae and Javanica had been reported in dogs [19,21] and high serological detection of serovars Bataviae and Javanica (32 out of 53 seropositive dogs) was directly linked to direct contact with rats. This is not surprising as Benacer et al, states that Bataviae and Javanica are two leptospiral serovars circulating among the urban rats' population in Peninsular Malaysia [28].…”

Section: Discussionmentioning

confidence: 98%

“…The panel of leptospiral serovars selected in this study was based on the important serovars circulating in Malaysia for human, rats and dogs as found in the previous studies [19,20,21,22,23,27]. It was observed that the three most frequent leptospiral serovars detected in diseased dogs were Bataviae (n = 12), Javanica (n = 10) and Icterohaemorrhagiae (n = 10), then followed by Ballum (n = 3), Australis (n = 3), Hardjobovis (n = 3), Malaysia (n = 3) and Pomona (n = 2).…”

Section: Discussionmentioning

confidence: 99%

“…In Malaysia, the seroprevalence of canine leptospirosis among dogs ranged from 3.1-22.2% [19,20,21,22]. However, there is a limited report in dogs diagnosed with kidney and/or liver disease locally.…”

Section: Introductionmentioning

confidence: 99%

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Detection and characterisation of Leptospira spp. in dogs diagnosed with kidney and/or liver disease

Rahman

Khor

Bejo

et al. 2020

Preprint

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Abstract Background Leptospirosis is a zoonotic bacterial disease that affects both humans and animals. In humans, a wide range of symptoms had been described but in dogs, it is commonly associated with kidney and/or liver disease. In Malaysia, information with regards to the common serovars causing leptospiral infection in dogs remains limited. Therefore, this study investigated the occurrences of leptospiral infection in 124 pet dogs diagnosed with kidney and/or liver disease in Malaysia. Results Based on microscopic agglutination test, 42.7% (53/124) of the dogs were seropositive for leptospiral infection. The predominant serovars detected were Bataviae (n = 12), Javanica (n = 10) and Icterohaemorrhagiae (n = 10). The direct detection using polymerase chain reaction showed that 33.9% (42/124) of the whole blood and 31.9% (36/113) of the urine samples were positive to pathogenic Leptospira spp. For tissue samples, 9.1% (2/23) of the kidney and 9.1% (2/23) of liver were positive for pathogenic Leptospira spp. Addition samples of abdominal effusion from four dogs were positive for pathogenic Leptospira spp. The species detected were L. interrogans, L. borgpetersenii, L. kirshneri and L. kmetyi by partial 16S rRNA sequencing. In this study, 11 Leptospira spp. isolated successfully from the eight dogs were further identified and characterised as Bataviae, Javanica and Australis. Unfortunately, the mortality rate of the infected dogs was high at 34.0% (18/53). Conclusions This study allowed for greater understanding of canine leptospirosis through the provision of crucial diagnostic confirmation.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Detection and characterisation of Leptospira spp. in dogs diagnosed with kidney and/or liver disease

Rahman

Khor

Bejo

et al. 2020

Preprint

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“…A (Gaudie et al, 2008;Ramirez-Ramirez et al, 2015) R* (Gaudie et al, 2008;Lau et al, 2017) SP (Boey et al, 2019) SP (Campos et al, 2017) A (Ellis and Michno, 1976) SP (Simbizi et al, 2016) SP (Lee et al, 2017) A (Arimitsu et al, 1989) SP (Barmettler et al, 2011) A (Arimitsu et al, 1989;Srinivas et al, 2013) Ballum A (Ferris et al, 1961) R* (Hathaway and Blackmore, 1981;Schuller et al, 2015) SP (Boey et al, 2019) SP (Yupiana et al, 2019) SP (Jung et al, 2010) SP (Yupiana et al, 2019) SP (Schuller et al, 2015) A (Matsui et al, 2015) Wolffii A (Zakeri et al, 2010) SP (Zakeri et al, 2010) SP (Boey et al, 2019) SP (Campos et al, 2017) SP (Siqueira et al, 2019) NE SP (Zakeri et al, 2010) SP (Tabata et al, 2002) Canicola A (Natarajaseenivasan et al, 2005;Ramirez-Ramirez et al, 2015) SP (Boey et al, 2019) R (Shenberg et al, 1977) SP (Zacarias et al, 2008;Campos et al, 2017) R (Zacarias et al, 2008) SP (Jung et al, 2010;Simbizi et al, 2016) SP (Lee et al, 2017) A…”

Section: The Complicated Relationship Of Leptospira and Various Host mentioning

confidence: 99%

Investigating the Immunological and Biological Equilibrium of Reservoir Hosts and Pathogenic Leptospira: Balancing the Solution to an Acute Problem?

Putz

Nally

2020

Front. Microbiol.

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Leptospirosis is a devastating zoonotic disease affecting people and animals across the globe. Pathogenic leptospires are excreted in urine of reservoir hosts which directly or indirectly leads to continued disease transmission, via contact with mucous membranes or a breach of the skin barrier of another host. Human fatalities approach 60,000 deaths per annum; though most vertebrates are susceptible to leptospirosis, complex interactions between host species and serovars of Leptospira can yield disease phenotypes that vary from asymptomatic shedding in reservoir hosts, to multiorgan failure in incidental hosts. Clinical symptoms of acute leptospirosis reflect the diverse range of pathogenic species and serovars that cause infection, the level of exposure, and the relationship of the pathogen with the given host. However, in all cases, pathogenic Leptospira are excreted into the environment via urine from reservoir hosts which are uniformly recognized as asymptomatic carriers. Therefore, the reservoir host serves as the cornerstone of persistent disease transmission. Although bacterin vaccines can be used to abate renal carriage and excretion in domestic animal species, there is an urgent need to advance our understanding of immune-mediated host-pathogen interactions that facilitate persistent asymptomatic carriage. This review summarizes the current understanding of host-pathogen interactions in the reservoir host and prioritizes research to unravel mechanisms that allow for colonization but not destruction of the host. This information is required to understand, and ultimately control, the transmission of pathogenic Leptospira.

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Shedding and Genetic Diversity of Leptospira spp. From Urban Stray Dogs in Klang Valley, Malaysia

Goh

Khor

Radzi

et al. 2021

Topics in Companion Animal Medicine

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Seroprevalence of Leptospirosis in Working Dogs

Cited by 23 publications

References 33 publications

Detection and characterisation of Leptospira spp. in dogs diagnosed with kidney and/or liver disease

Detection and characterisation of Leptospira spp. in dogs diagnosed with kidney and/or liver disease

Investigating the Immunological and Biological Equilibrium of Reservoir Hosts and Pathogenic Leptospira: Balancing the Solution to an Acute Problem?

Shedding and Genetic Diversity of Leptospira spp. From Urban Stray Dogs in Klang Valley, Malaysia

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