Seroprevalence of Leptospira Hardjo in Cattle and African Buffalos in Southwestern Uganda

Atherstone, Christine; Picozzi, Kim; Kalema‐Zikusoka, Gladys

doi:10.4269/ajtmh.13-0466

Cited by 23 publications

(26 citation statements)

References 12 publications

(16 reference statements)

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“…Detection of a high prevalence of anti-Leptospira antibodies against several Leptospira serogroups/serovars in cattle slaughtered at Ugandan abattoirs indicates that cattle are exposed to various Leptospira serogroups and serovars. This result supplements already existing data from studies that previously demonstrated anti-Leptospira antibodies in cattle (6,9), and one that confirmed renal Leptospira infection in cattle from various areas of Uganda (11). The latter study was conducted in the same abattoirs as the current study.…”

Section: Discussionsupporting

confidence: 90%

“…Despite evidence of both human and animal leptospirosis in Uganda, the epidemiology of the disease is still not wellinvestigated. Seropositivity to Leptospira species has been described in buffaloes (6) and in dogs 7, with the first case of clinical canine leptospirosis in Uganda reported recently (8). A random survey in beef and dairy cattle herds in two districts of Uganda revealed a seroprevalence of 19% (9).…”

Section: Introductionmentioning

confidence: 99%

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Leptospira Seroprevalence Among Ugandan Slaughter Cattle: Comparison of Sero-Status With Renal Leptospira Infection

et al. 2020

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Leptospira Seroprevalence Among Ugandan Slaughter Cattle: Comparison of Sero-Status With Renal Leptospira Infection

et al. 2020

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“…For East Africa, an annual incidence of 25.6 cases (95%CI 9.3–43.3) per 100,000 population was reported (Costa et al, ). In Uganda, seropositivity has been reported in buffaloes (Atherstone, Picozzi, & Kalema‐Zikusoka, ) and in dogs (Millán et al, ), with the first case of clinical canine leptospirosis recently reported (Alinaitwe, Kakooza, Eneku, Dreyfus, & Campos, ). Seroprevalence of 19% was reported in cattle from two districts in Uganda (Dreyfus et al, ).…”

Section: Introductionmentioning

confidence: 99%

Bovine leptospirosis in abattoirs in Uganda: Molecular detection and risk of exposure among workers

Alinaitwe

Kankya

Allan

et al. 2019

Zoonoses and Public Health

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Leptospirosis is a zoonotic bacterial disease reported worldwide. In Uganda, seropositivity has been reported in both humans and domesticated animals, including cattle. However, it remains unknown whether cattle are shedding leptospires and thus acting as potential source for human leptospirosis. We conducted this cross‐sectional study in two cattle abattoirs in Kampala, Uganda between June and July 2017. Kidney and urine samples from 500 cattle sourced from across the country were analysed by real‐time PCR to establish the prevalence of Leptospira‐positive cattle and risk of exposure to abattoir workers. The species of infecting Leptospira was determined by amplification of secY gene and compared to reference sequences published in GenBank. Of 500 cattle tested, 36 (7.2%) had Leptospira DNA in their kidneys (carriers), 29 (5.8%) in their urine (shedders); with an overall prevalence (kidney and/or urine) of 8.8%. Leptospira borgpetersenii was confirmed as the infecting species in three cattle and Leptospira kirschneri in one animal. Male versus female cattle (OR = 3, p‐value 0.003), exotic versus local breeds (OR = 21.3, p‐value 0.002) or cattle from Western Uganda (OR = 4.4, p‐value 0.001) and from regions across the border (OR = 3.3, p‐value 0.032) versus from the central region were more likely to be Leptospira‐positive. The daily risk of exposure of abattoir workers to ≥1 (kidney and/or urine) positive carcass ranged from 27% (95% credibility interval 18.6–52.3) to 100% (95% CI 91.0–100.0), with halal butchers and pluck inspectors being at highest risk. In conclusion, cattle slaughtered at abattoirs in Uganda carry and shed pathogenic Leptospira species; and this may pose occupation‐related risk of exposure among workers in these abattoirs, with workers who handle larger numbers of animals being at higher risk.

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“…The disease has been reported in humans in Gabon (Bertherat et al, 1999), in small mammals from Benin (Houemenou et al, 2013) and in rodents and buffalos in Kenya and Uganda (Halliday et al, 2013;Atherstone et al, 2013). In Tanzania, leptospirosis has been widely reported with high prevalence in rodents, cattle, dogs, pigs, and recently in bats (Machang'u et al, 1997;Mgode et al, 2005;Ahmed et al, 2006;Mgode et al, 2006;Schoonman, 2007;Schoonman & Swai, 2010;Kessy et al, 2010;Mgode et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Leptospira infections in freshwater fish in Morogoro Tanzania: a hidden public health threat

Mgode

Mhamphi

Katkweba

et al. 2014

Tanzania J Hlth Res

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Leptospirosis caused by spirochete bacterium of genus Leptospira affects humans and animals worldwide. Rodents are major reservoirs of leptospires whereas wetland and aquatic migratory birds also carry and transmit leptospires. Leptospirosis studies in fish are lacking in African countries despite favourable environment and abundant reservoirs, which can spread leptospires into aquatic habitats and infect fish. The objectives of this study were to determine presence of Leptospira in fish; the prevalent Leptospira serovars and whether are related to serovars reported in animals; and to ascertain potential public health risk. Live tilapia, catfish and eel fish (n=48) were caught in Mindu Dam in Morogoro Municipality in eastern Tanzania. Blood sample was collected using syringes and needles to obtain serum for serological detection of leptospirosis using gold standard microagglutination test utilizing local and reference Leptospira serovars Sokoine, Kenya, Pomona and Hebdomadis. Twenty-six fish (54.2%) were positive for serovar Kenya (29.2%) and Sokoine (25%). Leptospira prevalence was high in both catfish (58.3%) and tilapia fish (47.8%). Thus, different fish types are infected with Leptospira found in animals. Fish could be source of Leptospira infection to humans since tilapia and catfish are the common fish type widely consumed in Tanzania. Further study covering lakes, rivers and dams is required to better understand the prevalence of Leptospira in fish and actual public health threats.

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Seroprevalence of Leptospira Hardjo in Cattle and African Buffalos in Southwestern Uganda

Cited by 23 publications

References 12 publications

Leptospira Seroprevalence Among Ugandan Slaughter Cattle: Comparison of Sero-Status With Renal Leptospira Infection

Leptospira Seroprevalence Among Ugandan Slaughter Cattle: Comparison of Sero-Status With Renal Leptospira Infection

Bovine leptospirosis in abattoirs in Uganda: Molecular detection and risk of exposure among workers

Leptospira infections in freshwater fish in Morogoro Tanzania: a hidden public health threat

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